Cimetidine was given intravenously in daily dose of 20mg/kg to 20 patients with malignant tumor from the operative day on. The results show that cimetidine can elevate CD4, CD4/CD8 and decrease CD8. For comparison, blood samples from 40 patients were taken before operation for extracorporal testing. The results show that cimetidine can elevate lymphocyte transformation test and interleukin-2 secretive cell. These indicate that cimetidine can enhance the immune function of the patient and can be used as an adjunctive treatment of neoplasm.
Citation： Yang Zhengan,Ji Zongzheng,Zhou Yumin,etal.. EFFECTS OF CIMETIDINE ON PERIPHERAL BLOOD T CELL SUBSETS AND INTERLEUKIN-2 SECRETIVE CELL AND LYMPHOCYTE TRANSFORMATION TEST IN PATIENTS WITH MALIGNANT TUMOR. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1995, 2(4): 220-222. doi: Copy