EFFECT OF URSODEOXYCHOLATE ON BILIARY LPOID CONCENTRATIONS， NECLEATION TIME AND GALLBALADDER EMPTING IN JUMAN GALLBLADDER BILE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

He Youzhao ¹ , Zhang Peiming ¹ , Fang Kaixian. ²

Department of Hepato-Biliary-Pancreatic Disease, Affiliated Hospital of Luzhou Medical College, Luzhou 646000;

Corresponding author：

Keywords：

Ursodeoxycholic acid; Gallstone; Prevetion

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

The authors invrstigated whenther samll dose of ursodeoxycholic acif treatment influences biliary concentration, nucleation time and gallbladder empting. 3 patients with cholesferd gallstones receired 400 mg ursodeoxychilic acid per prior to cholecystectomy. Treatment with small dose of ursodeoxycholic acid decreased the gallbladder chlesterol saturation index and prolonged the nucleation time ,bur had no effect on gallbladder empyting. We bilieve that snall dose of ursodeoxyxholic acis mat prevent the gallstone formation by decreasing xholecterol saturation index and lengthening the nucleation time.

Citation： He Youzhao,Zhang Peiming,Fang Kaixian.. EFFECT OF URSODEOXYCHOLATE ON BILIARY LPOID CONCENTRATIONS， NECLEATION TIME AND GALLBALADDER EMPTING IN JUMAN GALLBLADDER BILE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1994, 1(2): 74-76. doi: Copy

1.	Lanzini A, Jazrrawi Rp, Jupfer Rm, et al. Gallstone recurrence after medical dissolution. An overdstimated threat? J hepatol, 1986;3:241.
2.	O’ Donnel LDJ, Heaton KW. Recurrence and re-recurrence of gall stones after medical dissolution: a longterm follow up. Gut, 1988;29:655.
3.	Nakagawa S, Makino I, Ichizaki, etal. Dissolution of cholesterol gallstones by ursodeoxycholic caid. Lancet, 1997;2:367.
4.	Tint GS, Salen G, Colalillo A, et al. Ursodeoxycholic acid: a safe and effective agent for dissolving cholesterol gallstones. Ann Intern Med,1982;97:351.
5.	Villanova N, Bazzoli F, Trabbani R, et al. Gallstone recurreence after successful oral bile acid treatment: a follow-up study and evaluation of long term post-dissolution treatment; 〔Abstract〕. Gastroenterology, 1987;92:1789.
6.	Holan KR, Holzbach RT, Hermann Re, et al. Nucleation time; a key factor in the pathogenesis of cholesterol gallstone disease. Gastroenterology, 1979;77:611.
7.	Hopman W, Brouwer W, Rosenbusch G, et al. A computerized method for rapid quantification of gallbladder volume from real-time sonograms. Radiology,1985;154:236.
8.	Somjen GJ, Gilat J, Contribution of vesicular and micellar carriers to cholecteril transport in human bile. J Lipid Res, 1985;26:899.
9.	Harvey PRC, Somjen G, LIchtengberg, et al, Nucleation of Cholesterol from cesicles isolated from bile of patients with the without cholesterol gallstne. Biochem Biophys Acta, 1987;921:198.
10.	Jungst D, Brenner G, Pratschke E, et al. Low-dose ursodeoxycholic acid prolongs cholecterol nucleation time in gallbladder bile of patients with cholesterol gallstones. J Hepatology, 1989;8:1.
11.	Hirota J, CHijiiwa K, Noxhiro H, et al . Effect of chnodexycholate and ursodeoxycholate on nucleation time in human gallbladder bile . Gastroenterology, 1992;102:1668.

1. Lanzini A, Jazrrawi Rp, Jupfer Rm, et al. Gallstone recurrence after medical dissolution. An overdstimated threat? J hepatol, 1986;3:241.
2. O’ Donnel LDJ, Heaton KW. Recurrence and re-recurrence of gall stones after medical dissolution: a longterm follow up. Gut, 1988;29:655.
3. Nakagawa S, Makino I, Ichizaki, etal. Dissolution of cholesterol gallstones by ursodeoxycholic caid. Lancet, 1997;2:367.
4. Tint GS, Salen G, Colalillo A, et al. Ursodeoxycholic acid: a safe and effective agent for dissolving cholesterol gallstones. Ann Intern Med,1982;97:351.
5. Villanova N, Bazzoli F, Trabbani R, et al. Gallstone recurreence after successful oral bile acid treatment: a follow-up study and evaluation of long term post-dissolution treatment; 〔Abstract〕. Gastroenterology, 1987;92:1789.
6. Holan KR, Holzbach RT, Hermann Re, et al. Nucleation time; a key factor in the pathogenesis of cholesterol gallstone disease. Gastroenterology, 1979;77:611.
7. Hopman W, Brouwer W, Rosenbusch G, et al. A computerized method for rapid quantification of gallbladder volume from real-time sonograms. Radiology,1985;154:236.
8. Somjen GJ, Gilat J, Contribution of vesicular and micellar carriers to cholecteril transport in human bile. J Lipid Res, 1985;26:899.
9. Harvey PRC, Somjen G, LIchtengberg, et al, Nucleation of Cholesterol from cesicles isolated from bile of patients with the without cholesterol gallstne. Biochem Biophys Acta, 1987;921:198.
10. Jungst D, Brenner G, Pratschke E, et al. Low-dose ursodeoxycholic acid prolongs cholecterol nucleation time in gallbladder bile of patients with cholesterol gallstones. J Hepatology, 1989;8:1.
11. Hirota J, CHijiiwa K, Noxhiro H, et al . Effect of chnodexycholate and ursodeoxycholate on nucleation time in human gallbladder bile . Gastroenterology, 1992;102:1668.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EFFECT OF URSODEOXYCHOLATE ON BILIARY LPOID CONCENTRATIONS， NECLEATION TIME AND GALLBALADDER EMPTING IN JUMAN GALLBLADDER BILE

Abstract Full text Figures/Tables Video References Cited by

Format

Content