31 case of advanced primary liver cancer were treated by using IL-2 and LAK cells in which 15 cases were combined with surgery (group A) and 16 cases were combined with chemotherpy (Group B). 7～14 months follow-up showed: In group A there was no recurence and metastasis, and the cell-mediated immunity was obviously improved. In group B, the average life time was more than 5.84 months, the tumor average diameter dicreased in 10 cases ,and the cee-mediated immunity was also improved. The role of immunotherapy combined with surgery or chemotherapy was discussed.
Citation：
Li Shaosen,Huang Yuan,Lu Quanshu,et al.. A REPORT ON THE TREATMENT OF PATIENTS WITH ADVANCED PRIMARY LIVER CANCER USING INTERLEUKIN-2 AND LYPHOKINE ACTIVATED KILLER CELLS COMVINED WITH SURGERY OR CHMOTHERAPY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1994, 1(2): 80-83. doi:
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吴孟超.肝脏外科进展.中华医学会第十届全国外科学术会议论文汇编，武汉：1993：1.
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郑鹏远，段芳龄，王军等.LAK细胞对人肝细胞的杀伤作用及其电镜观察.中华消化杂志，1993；13(3)：157.
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李志，权启镇，齐风等.IL-2/LAK细胞联合应用治疗原发性肝癌.山医学医药，1993；33(7)：5.
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砟文化.IL-2和5-Fu联合治疗晚期肝癌24例.实用癌症杂志，1993；8(3)：181.
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张松平，王能进.原发性肝癌根治术后复发因素分析.天津医药，1993；21(11)：666.
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朱敏生，许祥裕，丁树标等.5-Fu，MMC对外周血LAK细胞杀伤活性的影响.江苏医药，1990；(2)：70.
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- 1. 吴孟超.肝脏外科进展.中华医学会第十届全国外科学术会议论文汇编，武汉：1993：1.
- 2. 常旭(综述).原发性肝癌的免疫状态胶免疫治疗.国外医学肿瘤学分册，1992；2：136.
- 3. Rosnberg SA, Lotze MT, Yang JC, et al. Experience with use of high dose interleukin-2 in the treatment of 652 cancer patients. Ann Surg, 1989;210(4):474.
- 4. 郑鹏远，段芳龄，王军等.LAK细胞对人肝细胞的杀伤作用及其电镜观察.中华消化杂志，1993；13(3)：157.
- 5. 韩福刚，许红兵，梁厚勤.LAK细胞和IL-2治疗晚期肝癌10例.中华肿瘤杂志，1991；13(2)：145.
- 6. 李志，权启镇，齐风等.IL-2/LAK细胞联合应用治疗原发性肝癌.山医学医药，1993；33(7)：5.
- 7. 砟文化.IL-2和5-Fu联合治疗晚期肝癌24例.实用癌症杂志，1993；8(3)：181.
- 8. 张松平，王能进.原发性肝癌根治术后复发因素分析.天津医药，1993；21(11)：666.
- 9. 朱敏生，许祥裕，丁树标等.5-Fu，MMC对外周血LAK细胞杀伤活性的影响.江苏医药，1990；(2)：70.
