1993年10月至1994年2月对中—长链脂肪乳剂(实验组，n=40)和长链脂肪乳剂(对照组，n=30)在静脉营养中的疗效进行了对比观察。从术后第1天起，除从周围静脉输注必需液体外，每日静滴中—长链或长链脂肪乳剂500～1000ml，连续3～5天。监测项目包括血压、脉搏、呼吸、体温、血红蛋白、白细胞、肝肾功能、血甘油三酯及血胆固醇。结果显示：两组均无全笛反应；在输脂肪乳剂后6小时，两组血甘油三酯含量均明显升高，并于12小时时达峰值，16小时时已明显下降，但对照组明显高于实验组(P lt;0.05)，24小时时仍维持较高水平。由此表明，中—长链肪乳剂较易从血清中清除；中链甘油三酯能快速进入线粒体被氧化供能，不依赖内毒碱的转运，能经肝脏生成更多的酮体，极少再脂化为脂肪贮存起来。
Citation：
Shi De,Hu Luoli,Huang Ping,et al.. COMPARISON OF THERAPEUTIC EFFECTS BETWEEN LIPOFUNDIN AND INTRALIPID IN TOTAL PARENTERAL NURITION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1994, 1(2): 100-103. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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- 2. Carpentier BA, Richelle M, Haumont D, et al. New development in fat emulsion.Proceeding Natr Sociery, 1990;49:375.
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- 5. Ball MJ, White K.Comparison of medium and long chain riglyceride metabolism in intensive care patients on parenteral nutrition. Intensive Cate Med, 1989;15:250.
- 6. Gordon L, Jensen GL, Edward A, et al. Parenteral infusion of long-and medium-chain trilgycerides and reticulo-endothelial system function in man.JPEn, 1990;14:47.
- 7. Sedman PC, Ramsden CW, Brenman CW, et al. Pharmacological concentrations of lipid emusions inhibit interleukin-2 dependent lymphocyte responsed in vitro.JPEN, 1990;14:12.
- 8. Selman PC, Brenman S, Somer S, et al. Effects of different lipid emulsion on lymphoxyte function during total parenteral nutrition.Br J Surg, 1991;78:1396.
- 9. Maiz A, Yamazaki K, Sabrado J, et al. Peotein metacolism during total parenteral nutrition in injured rats using medium chain triglycerides. Metabolism, 1984;33:901.
