Diagnostic significance of brain natriuretic peptide in cardiac dyspnea_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

 YAO Guang , LAN Haiyun

Depatment of Cardiac Medicine，First People’s Hospital of Yulin.Yulin，Guangxi，537000，ChinaCorresponding author：YAO Guang，E-mail：yaodoctor@163.com;

Corresponding author：

YAO Guang, Email: yaodoctor@163.com

Keywords：

Brain natriuretic peptide; Acute dyspnea; Chronic heart failure

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the diagnostic value of brain natriuretic peptide (BNP) for cardiac dyspnea.Methods Plasma BNP levels were measured by radioimmunoassay in dyspnea patients with chronic heart failure (CHF) (n=52) or without CHF (n=30) and normal control group (n=28).Results The BNP level in dyspnea patients with CHF was significantly higher than that of dyspnea patients without CHF and normal control group [(649.80±141.72) pg/mL vs (59.08±18.60) pg/mL and (65.20±16.32) pg/mL，respectively,P lt;0.05].There was no significant difference of BNP level between dyspnea patients without CHF and normal group (P gt;0.05).The plasma BNP level elevated with the worsening of heart failure (NYHA Classiffication).The BNP level in dyspnea patients with CHF was negatively correlated with left ventricle ejection fraction (r=－0.673，P lt;0.001).The receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve (AUC) is 0.91(0.88-0.98，P lt;0.001) with a sensitivity of 87.2% and a specificity of 86.8% at the cutoff value of 206 pg/mL.Conclusion Measurement of plasma BNP is a rapid diagnostic method for cardiac dyspnea.

Citation： YAO Guang,LAN Haiyun. Diagnostic significance of brain natriuretic peptide in cardiac dyspnea. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(1): 52-54. doi: Copy

1.	McDonagh TA，Robb SD，Murdoch DR，et al.Biochemical detection of left ventricular systolic dysfunction.Lancet，1998，351：9-13.
2.	Cabanes L，Richaud-Thiriez B，Fulla Y，et al.Brain natriuretic peptide blood levels in the differential diagnosis of dyspnea.Chest，2001，120：2047-2050.
3.	陈协兴，洪华山，王一波，等.脑钠素在慢性心力衰竭诊断、预后评估中的价值.中国循环杂志，2003，18：434-436.
4.	Krishnaswamy P，Lubien E，Clopton P，et al.Utility of B-natriuretic peptide levels in identifying patients with left ventricular systolic or diastolic dysfunction.Am J Med，2001，111：274-279.
5.	Lubien E，DeMaria A，Krishnaaswamy P，et al.Utility of B-natriuretic peptide in detecting diastolic dysfunction：comparison with Doppler velocity recordings.Circulation，2002，105：595-601.
6.	吴彦，胡大一.B型脑钠素评价急性呼吸困难研究.中国医刊，2003，10：62-63.
7.	Mueller C，Laule-Kilian K，Christ A，et al.The use of B-type natriuretic peptide in the diagnosis of acute dyspnoea.Clin Lab，2005，51：5-9.
8.	黄培志，童朝阳，顾国荣，等.呼吸困难患者快速检测脑钠素的意义.上海医学，2005，28：61-63.
9.	曹向红，王凤芝，曹俊杰，等.血浆脑钠素在心源性和肺源性呼吸困难鉴别诊断中的价值.中国药物与临床，2004，4：116-119.
10.	Maisel AS，Krishnaswamy P，Nowak RM，et al.Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.N Engl J Med，2002，347：161-167.
11.	陈协兴，洪华山，王一波，等.慢性心力衰竭患者血清脑利钠肽水平的变化及其临床意义.中华临床药理学与治疗学，2003，8：631-634.

1. McDonagh TA，Robb SD，Murdoch DR，et al.Biochemical detection of left ventricular systolic dysfunction.Lancet，1998，351：9-13.
2. Cabanes L，Richaud-Thiriez B，Fulla Y，et al.Brain natriuretic peptide blood levels in the differential diagnosis of dyspnea.Chest，2001，120：2047-2050.
3. 陈协兴，洪华山，王一波，等.脑钠素在慢性心力衰竭诊断、预后评估中的价值.中国循环杂志，2003，18：434-436.
4. Krishnaswamy P，Lubien E，Clopton P，et al.Utility of B-natriuretic peptide levels in identifying patients with left ventricular systolic or diastolic dysfunction.Am J Med，2001，111：274-279.
5. Lubien E，DeMaria A，Krishnaaswamy P，et al.Utility of B-natriuretic peptide in detecting diastolic dysfunction：comparison with Doppler velocity recordings.Circulation，2002，105：595-601.
6. 吴彦，胡大一.B型脑钠素评价急性呼吸困难研究.中国医刊，2003，10：62-63.
7. Mueller C，Laule-Kilian K，Christ A，et al.The use of B-type natriuretic peptide in the diagnosis of acute dyspnoea.Clin Lab，2005，51：5-9.
8. 黄培志，童朝阳，顾国荣，等.呼吸困难患者快速检测脑钠素的意义.上海医学，2005，28：61-63.
9. 曹向红，王凤芝，曹俊杰，等.血浆脑钠素在心源性和肺源性呼吸困难鉴别诊断中的价值.中国药物与临床，2004，4：116-119.
10. Maisel AS，Krishnaswamy P，Nowak RM，et al.Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure.N Engl J Med，2002，347：161-167.
11. 陈协兴，洪华山，王一波，等.慢性心力衰竭患者血清脑利钠肽水平的变化及其临床意义.中华临床药理学与治疗学，2003，8：631-634.

Chinese Journal of Respiratory and Critical Care Medicine

Diagnostic significance of brain natriuretic peptide in cardiac dyspnea

Abstract Full text Figures/Tables Video References Cited by

Format

Content