雾化吸入速尿防治运动性哮喘的临床研究_Chinese Journal of Respiratory and Critical Care Medicine

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王志华

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雾化吸入; 速尿; 运动性哮喘

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在运动医学界，有一种运动作为诱发哮喘唯一因素的运动性疾病，称为运动性哮喘（EIA），是哮喘的特殊类型，发病地点多在运动场，起病较急，可危及运动员的生命，其发病机制至今尚未完全明了。速尿是一种袢利尿剂，也是15-羟前列腺素脱氢酶抑制剂，吸入速尿后对特应性和非特应性哮喘所致的支气管收缩有对抗作用[1]。目前国内尚未见应用速尿防治EIA的临床报道。我们通过观察患者吸入速尿前后、运动前后肺功能指标第1秒用力呼气容积（FEV1）占预计值百分比（FEV1%pred）及峰流速（PEF）的变化，探讨雾化吸入速尿对EIA的防治作用。

Citation： 王志华. 雾化吸入速尿防治运动性哮喘的临床研究. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(1): 62-63. doi: Copy

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1. Shimizu T，Mochizuki H，Morikawa A，et al.Inhaled furosemide prevents ultrasonically nebulized water bronchoconstricition in children with both atopic and nonatopic asthma.Chest，1993，104：1723-1726.
2. Eggleston PA，Rosenthal RR，Anderson SA，et al.Guidelines for the methodlody of exercise challenge in asthmaties.J Allergy Clin Immunol，1979，64：642-645.
3. Cypcar D，Lemanske RF Jr.Asthma and exercise.Clin Chest Med，1994，15：351-367.
4. Rupp NT，Guill MF，Brudno DS.Unrecognized exercise-induced bronchospasm in adolescent athletes.Am J Dis Child，1992，146：941-944.
5. Inman MD，Watson RM，Killian KJ，et al.Methacholine airway responsiveness decreases during exercise in asthmatic subjects.Am Rev Respir Dis，1990，141：1414-1417.
6. Parvord ID，Wisniewski A，Tatterfield AE.Inhaled frusemide and exercise induced asthma：evidence of a role for inhibitory prostanoids.Thorax，1992，47：797-800.
7. Miyanoshita A，Terada M，Endou H.Furosemide directly stimulates prostaglandin E2 production in the thick ascending limb of Henle’s loop.J Pharmacol Exp Ther，1989，251：1155-1159.
8. McFadden ER Jr.Hypothesis：Esercise-induced asthma as a vascular phenomenon.Lancet，1990，335：880-883.
9. Bianco S，Vajhi A，Robushi M，et al.Prevention of exerciseinduced bronchoconstriction by inhaled frusemide.Lancet，1988，2：252-255.

Chinese Journal of Respiratory and Critical Care Medicine

雾化吸入速尿防治运动性哮喘的临床研究

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