Allergen specific sublingual immunotherapy_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WU Kui ¹ , BI Yutian ¹ , WANG Changzheng ²

Respiratory Department of Daping Hospital, Third Military Medical University of Chinese PLA. Chongqing, 400042, China;

Corresponding author：

Keywords：

舌下变应原特异性免疫治疗; 哮喘; 鼻炎

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变应原特异性免疫治疗(SIT)是目前已知的唯一能改变变态反应性疾病患者对变应原免疫的类型，并有可能治愈变态反应性疾病的方法。通常是通过反复多次皮下注射，即皮下免疫治疗(SCIT)，诱导患者对变应原的耐受，但因其不良反应较大，并有可能引起过敏性休克等原因而使其应用受到限制。近来通过舌下含服的方法进行免疫治疗，即舌下免疫治疗(SLIT)，引起了临床上广泛的兴趣。与SCIT相比，SLIT完全由患者自己使用药物，因此更方便，临床研究也证实这种方法更安全，也更有效。而且与药物治疗相比，SLIT可以显著降低临床费用，减轻患者和社会的负担。但是SLIT诱导免疫耐受的确切机制目前仍不清楚。

Citation： WU Kui,BI Yutian,WANG Changzheng. Allergen specific sublingual immunotherapy. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(5): 321-325. doi: Copy

1.	Passalacqua G，Guerra L，Pasquali M，et al.Efficacy and safety of sublingual immunotherapy.Ann Allergy Asthma Immunol，2004，93：3-12.
2.	Bagnasco M，Passalacqua G，Villa G，et al.Pharmacokinetics of an allergen and a monomeric allergoid for oromucosal immunotherapy in allergic volunteers.Clin Exp Allergy，2001，31：54-60.
3.	Walker GF，Langoth N，Bernkop-Schnürch A.Peptidase activity on the surface of the porcine buccal mucosa，2002，233：141-147.
4.	Bousquet J，Van Cauwenberge P，Khaltaev N，et al.Allergic rhinitis and its impact on asthma.J Allergy Clin Immunol，2001，108：S147-334.
5.	Wilson DR，Lima MT，Durham SR.Sublingual immunotherapy for allergic rhinitis：systematic review and meta-analysis.Allergy，2005，60：4-12.
6.	Lowenstein H，LarsenJN.Recombinant allergens/allergen standardization.Curr Allergy Asthma Rep，2001，1：474-479.
7.	Moingeon P.Sublingual immunotherapy：from biological extracts to recombinant allergens.Allergy，2006，Suppl 81：15-19.
8.	Baena-Cagnani CE，Passalacqua G，Baena-Cagnani RC，et al.Sublingual immunotherapy in pediatric patients：beyond clinical efficacy.Curr Opin Allergy Clin Immunol.2005，5：173-177.
9.	Pajno GB，Morabito L，Barberio G，et al.Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites：a double-blind，placebo-controlled study.Allergy，2000，55：842-849.
10.	Ippoliti F，De Santis W，Volterrani A，et al.Immunomodulation during sublingual therapy in allergic children.Pediatr Allergy Immunol，2003，14：216-221.
11.	Rolinck-Werninghaus C，Wolf H，Liebke C，et al.A prospective，randomized，double-blind，placebo-controlled multi-centre study on the efficacy and safety of sublingual immunotherapy（SLIT） in children with seasonal allergic rhinoconjunctivitis to grass pollen.Allergy，2004，59：1285-1293.
12.	Novembre E，Galli E，Landi F，et al.Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis.J Allergy Clin Immunol，2004，114：851-857.
13.	Di Rienzo V，Marcucci F，Puccinelli P，et al.Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite：a 10-year prospective study.Clin Exp Allergy，2003，33：206-210.
14.	Tonnel AB，Scherpereel A，Douay B，et al.Allergic rhinitis due to house dust mites：evaluation of the efficacy of specific sublingual immunotherapy.Allergy，2004，59：491-497.
15.	Berto P，Passalacqua G，Crimi N，et al.Economic evaluation of sublingual immunotherapy vs symptomatic treatment in adults with pollen-induced respiratory allergy：the Sublingual Immunotherapy Pollen Allergy Italy（SPAI） study.Ann Allergy Asthma Immunol，2006，97：615-621.
16.	Calamita Z，Saconato H，Pela AB，et al.Efficacy of sublingual immunotherapy in asthma：systematic review of randomized-clinical trials using the Cochrane Collaboration method.Allergy，2006，61：1162-1172.
17.	Malling HJ.Sublingual immunotherapy：efficacy--methodology and outcome of clinical trials.Allergy，2006，Suppl 81：24-28.
18.	Wilson DR，Torres LI，Durham SR.Sublingual immunotherapy for allergic rhinitis（Cochrane review）.Cochrane Database Syst Rev，2003，CD002893.
19.	Marogna M，Bruno M，Massolo A，Falagiani P.Long-lasting effects of sublingual immunotherapy for house dust mites in allergic rhinitis with bronchial hyperreactivity：A long-term（13-year） retrospective study in real life.Int Arch Allergy Immunol，2007，142：70-78.
20.	Bordignon V，Burastero SE.Multiple daily administrations of low-dose sublingual immunotherapy in allergic rhinoconjunctivitis.Ann Allergy Asthma Immunol，2006，97：158-163.
21.	Savolainen J，Jacobsen L，Valovirta E.Sublingual immunotherapy in children modulates allergen-induced in vitro expression of cytokine mRNA in PBMC.Allergy，2006，61：1184-1190.
22.	Valovirta E，Jacobsen L，Ljørring C，et al.Clinical efficacy and safety of sublingual immunotherapy with tree pollen extract in children.Allergy，2006，61：1177-1183.
23.	Frati F，Incorvaia C，Marcucci F，et al.Dose dependence of efficacy but not of safety in sublingual immunotherapy.Monaldi Arch Chest Dis，2006，65：38-40.
24.	Cox LS，Linnemann DL，Nolte H，et al.Sublingual immunotherapy：a comprehensive review.J Allergy Clin Immunol，2006，117：1021-1035.
25.	Penagos M，Compalati E，Tarantini F，et al.Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age：a meta-analysis of randomized，placebo-controlled，double-blind trials.Ann Allergy Asthma Immunol，2006，97：141-148.
26.	Lue KH，Lin YH，Sun HL，et al.Clinical and immunologic effects of sublingual immunotherapy in asthmatic children sensitized to mites：a double-blind，randomized，placebo-controlled study.Pediatr Allergy Immunol，2006，17：408-415.
27.	Gidaro GB，Marcucci F，Sensi L，et al.The safety of sublingual-swallow immunotherapy：an analysis of published studies.Clin Exp Allergy，2005，35：565-571.
28.	Rienzo VD，Minelli M，Musarra A，et al.Post-marketing survey on the safety of sublingual immunotherapy in children below the age of 5 years.Clin Exp Allergy，2005，35：560-564.
29.	Fiocchi A，Pajno G，La Grutta S，et al.Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years.Ann Allergy Asthma Immunol，2005，95：254-258.
30.	Larsen TH，Poulsen LK，Melac M，et al.Safety and tolerability of grass pollen tablets in sublingual immunotherapy--a phase-1 study.Allergy，2006，61：1173-1176.
31.	Pajno GB，Peroni DG，Vita D，et al.Safety of sublingual immunotherapy in children with asthma.Paediatr Drugs，2003，5：777-781.
32.	Pajno GB，Vita D，Caminiti L，et al.Children’s compliance with allergen immunotherapy according to administration routes.J Allergy Clin Immunol，2005，116：1380-1381.
33.	Berto P，Bassi M，Incorvaia C，et al.Cost effectiveness of sublingual immunotherapy in children with allergic rhinitis and asthma.Allergy Immunol，2005，36：303-308.
34.	Moingeon P，Batard T，Fadel R，et al.Immune mechanisms of allergen-specific sublingual immunotherapy.Allergy，2006，61：151-165.
35.	Allam JP，Niederhagen B，Bucheler M，et al.Comparative analysis of nasal and oral mucosa dendritic cells.Allergy，2006，61：166-172.
36.	Bahceciler NN，Arikan C，Taylor A，et al.Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites.Int Arch Allergy Immunol，2005，136：287-294.
37.	Cosmi L，Santarlasci V，Angeli R，et al.Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-production.Clin Exp Allergy，2006，36：261-272.
38.	Akdis M，Verhagen J，Taylor A，et al.Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells.J Exp Med. 2004，199：1567-1575.
39.	Ciprandi G，Fenoglio D，Cirillo I，et al.Induction of interleukin 10 by sublingual immunotherapy for house dust mites：a preliminary report.Ann Allergy Asthma Immunol，2005，95：38-44.
40.	Ippoliti F，De Santis W，Volterrani A，et al.Immunomodulation during sublingual therapy in allergic children.Pediatr Allergy Immunol，2003，14：216-221.
41.	Marcucci F，Sensi L，Frati F，et al.Sublingual tryptase and ECP in children treated with grass pollen sublingual immunotherapy（SLIT）：safety and immunologic implications.Allergy，2001，56：1091-1095.
42.	Marcucci F，Sensi L，Frati F，et al.Effects on inflammation parameters of a double-blind，placebo controlled one-year course of SLIT in children monosensitized to mites.Allergy，2003，58：657-662.
43.	Silverstri M，Spallarossa D，Battistini F，et al.Changes in inflammatory and clinical parameters and in bronchial hyperreactivity asthmatic children sensitized to house dust mites following sublingual immunotherapy.J Investig Allergol Clin Immunol，2002，12：52-59.
44.	Allam JP，Novak N，Fuchs C，et al.Characterization of dendritic cells from human oral mucosa：a new Langerhans’ cell type with high constitutive FcepsilonRI expression.J Allergy Clin Immunol，2003，112：141-148.
45.	程相铎，梅海豫，胡光荣.口服螨液免疫治疗过敏性哮喘.临床军医杂志，2003，31：18-19.
46.	赵京，陈育智，丁燕，等.口服螨免疫疗法辅助治疗儿童哮喘疗效观察.中国实用儿科杂志，1999，14：661-663.
47.	程志英，汪新，王国洪，等.变应原疫苗雾化吸入对支气管哮喘患者Th1/Th2细胞因子平衡的调控.临床耳鼻喉科杂志，2006，20：790-792.

1. Passalacqua G，Guerra L，Pasquali M，et al.Efficacy and safety of sublingual immunotherapy.Ann Allergy Asthma Immunol，2004，93：3-12.
2. Bagnasco M，Passalacqua G，Villa G，et al.Pharmacokinetics of an allergen and a monomeric allergoid for oromucosal immunotherapy in allergic volunteers.Clin Exp Allergy，2001，31：54-60.
3. Walker GF，Langoth N，Bernkop-Schnürch A.Peptidase activity on the surface of the porcine buccal mucosa，2002，233：141-147.
4. Bousquet J，Van Cauwenberge P，Khaltaev N，et al.Allergic rhinitis and its impact on asthma.J Allergy Clin Immunol，2001，108：S147-334.
5. Wilson DR，Lima MT，Durham SR.Sublingual immunotherapy for allergic rhinitis：systematic review and meta-analysis.Allergy，2005，60：4-12.
6. Lowenstein H，LarsenJN.Recombinant allergens/allergen standardization.Curr Allergy Asthma Rep，2001，1：474-479.
7. Moingeon P.Sublingual immunotherapy：from biological extracts to recombinant allergens.Allergy，2006，Suppl 81：15-19.
8. Baena-Cagnani CE，Passalacqua G，Baena-Cagnani RC，et al.Sublingual immunotherapy in pediatric patients：beyond clinical efficacy.Curr Opin Allergy Clin Immunol.2005，5：173-177.
9. Pajno GB，Morabito L，Barberio G，et al.Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites：a double-blind，placebo-controlled study.Allergy，2000，55：842-849.
10. Ippoliti F，De Santis W，Volterrani A，et al.Immunomodulation during sublingual therapy in allergic children.Pediatr Allergy Immunol，2003，14：216-221.
11. Rolinck-Werninghaus C，Wolf H，Liebke C，et al.A prospective，randomized，double-blind，placebo-controlled multi-centre study on the efficacy and safety of sublingual immunotherapy（SLIT） in children with seasonal allergic rhinoconjunctivitis to grass pollen.Allergy，2004，59：1285-1293.
12. Novembre E，Galli E，Landi F，et al.Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis.J Allergy Clin Immunol，2004，114：851-857.
13. Di Rienzo V，Marcucci F，Puccinelli P，et al.Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite：a 10-year prospective study.Clin Exp Allergy，2003，33：206-210.
14. Tonnel AB，Scherpereel A，Douay B，et al.Allergic rhinitis due to house dust mites：evaluation of the efficacy of specific sublingual immunotherapy.Allergy，2004，59：491-497.
15. Berto P，Passalacqua G，Crimi N，et al.Economic evaluation of sublingual immunotherapy vs symptomatic treatment in adults with pollen-induced respiratory allergy：the Sublingual Immunotherapy Pollen Allergy Italy（SPAI） study.Ann Allergy Asthma Immunol，2006，97：615-621.
16. Calamita Z，Saconato H，Pela AB，et al.Efficacy of sublingual immunotherapy in asthma：systematic review of randomized-clinical trials using the Cochrane Collaboration method.Allergy，2006，61：1162-1172.
17. Malling HJ.Sublingual immunotherapy：efficacy--methodology and outcome of clinical trials.Allergy，2006，Suppl 81：24-28.
18. Wilson DR，Torres LI，Durham SR.Sublingual immunotherapy for allergic rhinitis（Cochrane review）.Cochrane Database Syst Rev，2003，CD002893.
19. Marogna M，Bruno M，Massolo A，Falagiani P.Long-lasting effects of sublingual immunotherapy for house dust mites in allergic rhinitis with bronchial hyperreactivity：A long-term（13-year） retrospective study in real life.Int Arch Allergy Immunol，2007，142：70-78.
20. Bordignon V，Burastero SE.Multiple daily administrations of low-dose sublingual immunotherapy in allergic rhinoconjunctivitis.Ann Allergy Asthma Immunol，2006，97：158-163.
21. Savolainen J，Jacobsen L，Valovirta E.Sublingual immunotherapy in children modulates allergen-induced in vitro expression of cytokine mRNA in PBMC.Allergy，2006，61：1184-1190.
22. Valovirta E，Jacobsen L，Ljørring C，et al.Clinical efficacy and safety of sublingual immunotherapy with tree pollen extract in children.Allergy，2006，61：1177-1183.
23. Frati F，Incorvaia C，Marcucci F，et al.Dose dependence of efficacy but not of safety in sublingual immunotherapy.Monaldi Arch Chest Dis，2006，65：38-40.
24. Cox LS，Linnemann DL，Nolte H，et al.Sublingual immunotherapy：a comprehensive review.J Allergy Clin Immunol，2006，117：1021-1035.
25. Penagos M，Compalati E，Tarantini F，et al.Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age：a meta-analysis of randomized，placebo-controlled，double-blind trials.Ann Allergy Asthma Immunol，2006，97：141-148.
26. Lue KH，Lin YH，Sun HL，et al.Clinical and immunologic effects of sublingual immunotherapy in asthmatic children sensitized to mites：a double-blind，randomized，placebo-controlled study.Pediatr Allergy Immunol，2006，17：408-415.
27. Gidaro GB，Marcucci F，Sensi L，et al.The safety of sublingual-swallow immunotherapy：an analysis of published studies.Clin Exp Allergy，2005，35：565-571.
28. Rienzo VD，Minelli M，Musarra A，et al.Post-marketing survey on the safety of sublingual immunotherapy in children below the age of 5 years.Clin Exp Allergy，2005，35：560-564.
29. Fiocchi A，Pajno G，La Grutta S，et al.Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years.Ann Allergy Asthma Immunol，2005，95：254-258.
30. Larsen TH，Poulsen LK，Melac M，et al.Safety and tolerability of grass pollen tablets in sublingual immunotherapy--a phase-1 study.Allergy，2006，61：1173-1176.
31. Pajno GB，Peroni DG，Vita D，et al.Safety of sublingual immunotherapy in children with asthma.Paediatr Drugs，2003，5：777-781.
32. Pajno GB，Vita D，Caminiti L，et al.Children’s compliance with allergen immunotherapy according to administration routes.J Allergy Clin Immunol，2005，116：1380-1381.
33. Berto P，Bassi M，Incorvaia C，et al.Cost effectiveness of sublingual immunotherapy in children with allergic rhinitis and asthma.Allergy Immunol，2005，36：303-308.
34. Moingeon P，Batard T，Fadel R，et al.Immune mechanisms of allergen-specific sublingual immunotherapy.Allergy，2006，61：151-165.
35. Allam JP，Niederhagen B，Bucheler M，et al.Comparative analysis of nasal and oral mucosa dendritic cells.Allergy，2006，61：166-172.
36. Bahceciler NN，Arikan C，Taylor A，et al.Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites.Int Arch Allergy Immunol，2005，136：287-294.
37. Cosmi L，Santarlasci V，Angeli R，et al.Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-production.Clin Exp Allergy，2006，36：261-272.
38. Akdis M，Verhagen J，Taylor A，et al.Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells.J Exp Med. 2004，199：1567-1575.
39. Ciprandi G，Fenoglio D，Cirillo I，et al.Induction of interleukin 10 by sublingual immunotherapy for house dust mites：a preliminary report.Ann Allergy Asthma Immunol，2005，95：38-44.
40. Ippoliti F，De Santis W，Volterrani A，et al.Immunomodulation during sublingual therapy in allergic children.Pediatr Allergy Immunol，2003，14：216-221.
41. Marcucci F，Sensi L，Frati F，et al.Sublingual tryptase and ECP in children treated with grass pollen sublingual immunotherapy（SLIT）：safety and immunologic implications.Allergy，2001，56：1091-1095.
42. Marcucci F，Sensi L，Frati F，et al.Effects on inflammation parameters of a double-blind，placebo controlled one-year course of SLIT in children monosensitized to mites.Allergy，2003，58：657-662.
43. Silverstri M，Spallarossa D，Battistini F，et al.Changes in inflammatory and clinical parameters and in bronchial hyperreactivity asthmatic children sensitized to house dust mites following sublingual immunotherapy.J Investig Allergol Clin Immunol，2002，12：52-59.
44. Allam JP，Novak N，Fuchs C，et al.Characterization of dendritic cells from human oral mucosa：a new Langerhans’ cell type with high constitutive FcepsilonRI expression.J Allergy Clin Immunol，2003，112：141-148.
45. 程相铎，梅海豫，胡光荣.口服螨液免疫治疗过敏性哮喘.临床军医杂志，2003，31：18-19.
46. 赵京，陈育智，丁燕，等.口服螨免疫疗法辅助治疗儿童哮喘疗效观察.中国实用儿科杂志，1999，14：661-663.
47. 程志英，汪新，王国洪，等.变应原疫苗雾化吸入对支气管哮喘患者Th1/Th2细胞因子平衡的调控.临床耳鼻喉科杂志，2006，20：790-792.

Chinese Journal of Respiratory and Critical Care Medicine

Allergen specific sublingual immunotherapy

Abstract Full text Figures/Tables Video References Cited by

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