Acute Exacerbation of Idiopathic Pulmonary Fibrosis: Imaging Characteristics under High Resolution Computed Tomography_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

WANG Xingsheng ¹ , WU Xueling ² , CAO Guoqiang ¹ , YANG Xuemei ¹ , HUANG Yong ¹ ,  CUI Shehuai. ¹

Department of Respiratory Disease, Daping Hospital, Third Military Medical University. Chongqing, 400042, ChinaCorresponding Author: CUI She-huai, E-mail: dpcsh@ tom. com;

Corresponding author：

CUI Shehuai., Email: dpcsh@tom.com

Keywords：

Idiopathic pulmonary fibrosis; Acute exacerbation; High-resolution computed tomography; Imageology

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Objective To explore the imaging features of acute exacerbation of idiopathic pulmonary fibrosis ( IPF) under high-resolution computed tomography ( HRCT) . Methods The HRCT imaging features of six patients who met the criteria for acute exacerbation of IPF were analyzed retrospectively. Results The manifestations of IPF on HRCT scan were various in forms and distribution, as multifocal, ground-glass opacity, reticular shadow, honeycombing densities, capillary bronchiectasis,subpleural lines, traction bronchiolectasis and emphysema. The characteristic lesions were newly diffuse bilateral ground-glass opacity at the time of acute exacerbation, superimposed on subpleural reticular and honeycombing densities. Conclusions Chest HRCT findings in acute exacerbation of IPF are characteristic.HRCT is accurate and superior in diagnosis of IPF and in determining acute exacerbation of IPF.

Citation： WANG Xingsheng,WU Xueling,CAO Guoqiang,YANG Xuemei,HUANG Yong,CUI Shehuai.. Acute Exacerbation of Idiopathic Pulmonary Fibrosis: Imaging Characteristics under High Resolution Computed Tomography. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(1): 36-38. doi: Copy

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1. Selman M,King TE,Pardo A.Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy.Ann Intern Med,2001,134:136-151.
2. American Thoracic Society.Idiopathic pulmonary fibrosis: diagnosis and treatment.International consensus statement.American Thoracic Society (ATS),and the European Respiratory Society (ERS).Am J Respir Crit Care Med,2000,161:646-664.
3. Enomoto T,Kawamoto M,Kunugi S,et al.Clinicopathological analysis of patients with idiopathic pulmonary fibrosis which became acutely exacerbated after video-assisted thoracoscopic surgical lung biopsy.Nihon Kokyuki Gakkai Zasshi,2002,40:806-811.
4. Nishiyama O,Shimizu M,Ito Y,et al.Effect of prolonged low-dose methylprednisolone therapy in acute exacerbation of idiopathic pulmonary fibrosis.Respir Care,2001,46:698-701.
5. Martinez FJ,Safrin S,Weycker D,et al.The clinical course of patients with idiopathic pulmonary fibrosis.Ann Intern Med,2005,142:963-967.
6. 中华医学会呼吸病学分会.特发性肺（间质）纤维化诊断和治疗指南（草案）.中华内科杂志,2002,41:498-500.
7. Kondoh Y,Taniguchi H,Kawabata Y,et al.Acute exacerbation in idiopathic pulmonary fibrosis.Analysis of clinical and pathologic findings in three cases.Chest,1993,103:1808-1812.
8. Katzenstein AL,Myers JL.Idiopathic pulmonary fibrosis: clinical relevance of pathologic classification.Am J Respir Crit Care Med,1998,157:1301-1315.
9. Collard HR,Ryu JH,Douglas WW,et al.Combined corticosteroid and cyclophosphamide therapy does not alter survival in idiopathic pulmonary fibrosis.Chest,2004,125:2169-2174.
10. Sugino S,Kanaya N,Namiki A.A case of acute exacerbation of idiopathic interstitial pneumonia after pneumonectomy.Masui,2000,49:187-190.
11. 张瑞禄，万业达.胸部常见疾病多层螺旋CT诊断与临床.第1版.天津:天津科技翻译出版社,2006.82-91.
12. 蒋昭实,刘鸿瑞.普通性间质性肺炎的病理诊断.中华结核和呼吸杂志,2000,23:15-18.
13. Lynch DA,David Godwin J,Safrin S,et al.High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis..Am J Respir Crit Care Med,2005,172:488-493.
14. McLoud TC.Role of high-resolution computed tomography in idiopathic pulmonary fibrosis: the final word?.Am J Respir Crit Care Med,2005,172:408-409.

Chinese Journal of Respiratory and Critical Care Medicine

Acute Exacerbation of Idiopathic Pulmonary Fibrosis: Imaging Characteristics under High Resolution Computed Tomography

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