阻塞性睡眠呼吸暂停低通气综合征合并高血压患者血浆同型半胱氨酸的变化_Chinese Journal of Respiratory and Critical Care Medicine

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徐春华 ¹ , 林勇 ²

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阻塞性睡眠呼吸暂停低通气综合征; 高血压; 同型半胱氨酸

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目的探讨同型半胱氨酸( HCY) 在OSAHS 合并高血压发病中的作用。方法检测22例OSAHS 合并高血压患者、20 例OSAHS不伴高血压患者血浆HCY 水平, 并与对照组比较, 将检测结果与睡眠呼吸监测( PSG) 指标进行相关性分析。PSG 监测指标包括呼吸暂停低通气指数( AHI) 、血氧饱和度小于90% 占总睡眠时间百分比( SLT90% ) 、最低血氧饱和度( LSaO2 ) 、平均血氧饱和度( MSaO2 ) 、觉醒指数( AI) 、睡眠呼吸暂停最长时间( LAT) 。结果 OSAHS 不伴高血压患者血浆HCY明显高于对照组[ ( 18. 28 ±6. 80) μmol /L 比( 6. 32 ±3. 95) μmol /L, P lt;0. 01] , OSAHS 合并高血压组与OSAHS 不伴高血压组比较血浆HCY 进一步升高[ ( 23. 83 ±5. 90) μmol /L 比( 18. 28 ±6. 80) μmol /L, P lt;0. 01] 。血浆HCY 水平与OSAHS 不伴高血压组及OSAHS 合并高血压组的AHI、SLT90% 均呈正相关( P 均 lt;0.01) , 与LSaO2、MSaO2 均呈负相关( P 均 lt;0. 01) 。结论 HCY 参与了OSAHS 的病理生理过程, 在OSAHS 合并高血压患者发病中起一定作用。

Citation： 徐春华,林勇. 阻塞性睡眠呼吸暂停低通气综合征合并高血压患者血浆同型半胱氨酸的变化. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(2): 195-197. doi: Copy

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1. Arruda-Olson AM, Olson LJ, Nehra A, et al. Sleep apnea and cardiovascular disease. Implications for understanding erectile dysfunction. Herz, 2003 , 28: 298-303.
2. Del-Colle S, Renata C, Farrar R, et al. Hypertension in obstructive sleep apnoea. Vascular Disease Prevention, 2005, 2: 29-35.
3. Nieto FJ, Young TB, Lind BK, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA, 2000, 283: 1829-1836.
4. Montalescot G, Ankri A, Chadefaux-Vekemans B, et al. Plasma homocysteine and the extent of atherosclerosis in patients with coronary artery disease. Int J Cardiol, 1997, 60 : 295-300.
5. 中华医学会呼吸病学分会睡眠呼吸疾病学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南( 草案) . 中华结核和呼吸杂志,2002, 25: 195-198 .
6. 中国高血压防治指南起草委员会. 中国高血压防治指南( 试行本) . 北京: 中华人民共和国卫生部/ 中国高血压联盟, 2005, 14 -17.
7. Lavie L. Obstructive sleep apnoea syndrome--an oxidative stress disorder. Sleep Med Rev, 2003, 7 : 35-51.
8. Lavie L, Perelman A, Lavie P. Plasma homocysteine in obstructive sleep apnoea. Chest, 2001 , 120: 900-908 .
9. Svatikova A, Wolk R, Magera MJ, et al. Plasma homocysteine in obstructive sleep apnoea. Eur Heart J, 2004, 25: 1325-1329.
10. Can M, A ikg z S, Mungan G, et al. Serum cardiovascular risk factors in obstructive sleep apnea. Chest, 2006, 129 : 233-237.
11. Jordan W, Berger C, Cohrs S, et al. CPAP-therapy effectively lowers serum homocysteine in obstructive sleep apnea syndrome. J Neural Transm, 2004, 111 : 683-689.
12. Kokturk O, Ciftci TU, Mollarecep E, et al. Serum homocysteine levels and cardiovascular morbidity in obstructive sleep apnea syndrome. Respir Med, 2006, 100: 536-541.

Chinese Journal of Respiratory and Critical Care Medicine

阻塞性睡眠呼吸暂停低通气综合征合并高血压患者血浆同型半胱氨酸的变化

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