Association Between Serum Level of Hepatocyte Growth Factor and OSAHS with Hypertension_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

MING Huaikun , OUYANG Songyun , SUN Peizong , JIANG Junguang , WU Shuzhen , LI Weilan , HOU Qian.

Department of Respiratory and Sleep Disease, The First Affiliated Hospital of Zhengzhou University.Zhengzhou, He’nan, 450052, ChinaCorresponding Author: OUYANG Song-yun, E-mail: oysy@ sohu. com;

Corresponding author：

Keywords：

Hepatocyte growth factor; Obstructive sleep apnea hypopnea syndrome; Hypertension

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Objective To investigate the possible association between serum level of hepatocyte growth factor( HGF) and obstructive sleep apnea hypopnea syndrome( OSAHS) with hypertension.Methods 58 cases of OSAHS without hypertension, 61 cases of OSAHS with hypertension, and 50 normal controls were enrolled. Serum level of HGF was measured by enzyme-linked immunosorbent assay( ELISA) , and the relationships between the serum HGF level and blood pressure( BP) , apnea hypopnea index( AHI) , lowest SaO2 ( LSaO2 ) were analyzed by linear correlation analysis. Results The serum HGF level ( pg/mL) was 761. 46 ±60. 18, 970. 87 ±60. 94, and 487. 34 ±45. 52 in the OSAHS patients without hypertention, OSAHS patients with hypertention, and normal subjects, respectively. Which was significantly higher in the OSAHS
patients than the normal subjects, and highest in the OSAHS patients with hypertension( P lt; 0. 05) . The serum HGF level was positively related to AHI( r = 0. 452, P lt;0. 05) and negatively related to LSaO2 ( r =- 0. 328, P lt;0. 05) in the OSAHS patients without hypertention, positively related to AHI, SBP, DBP( r =0. 670, P lt;0. 01; r =0. 535, P lt;0. 05; r =0. 424, P lt;0. 05) and negatively related to LSaO2 ( r = - 0. 572,P lt;0. 01) in the OSAHS patients with hypertension. Conclusions SerumHGF level increases significantly in patients with OSAHS especialy in OSAHS patients with hypertension, and positively correlates with the severity of OSAHS and hypertension.

Citation： MING Huaikun,OUYANG Songyun,SUN Peizong,JIANG Junguang,WU Shuzhen,LI Weilan,HOU Qian.. Association Between Serum Level of Hepatocyte Growth Factor and OSAHS with Hypertension. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(3): 249-252. doi: Copy

1.	王玮. 阻塞性睡眠呼吸暂停低通气综合征与血管内皮功能紊乱. 中华结核和呼吸杂志, 2008, 31: 650 -652.
2.	王邦宁, 胡泽平, 陈大年, 等. 高血压患者肝细胞生长因子与血管内皮功能的关系及干预研究. 中华高血压杂志, 2007, 15: 219 -222 .
3.	中华医学会呼吸病学分会睡眠呼吸疾病学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南( 草案) . 中华结核和呼吸杂志,2002, 25: 195-198.
4.	Stoker M, Gherardi E, Perryman M, et al. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature,1987, 327 : 239-242.
5.	Kuhlmann CR, Schaefer CA, Fehsecke A, et al. A new signaling mechanism of hepatocyte growth factor-induced endothelial proliferation. J Thromb Haemost, 2005 , 3: 2089 -2095 .
6.	Uruno A, Sugawara A, Kanatsuka H, et al. Hepatocyte growth factor stimulates nitric oxide production through endothelial nitric oxide synthase activation by the phosphoinositide 3-kinase/ Akt pathway and possibly by mitogen-activated protein kinase kinase in vascular endothelial cells. Hypertens Res, 2004, 27: 887-895.
7.	钱瑾邺, 王邦宁. HGF 在高血压和肾素-血管紧张素系统中的研究进展. 山东医药, 2008, 48: 139-140 .
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9.	陈建英, 杨天伦, 陈灿, 等. 高血压病患者血清肝细胞生长因子与低密度脂蛋白及左室重塑的关系. 中国现代医学杂志, 2003 ,13: 19 -21 .
10.	李萍, 杨庭树. 肝细胞生长因子在心血管疾病诊断及治疗中的应用. 中国康复理论与实践, 2006 , 12 : 966-967.
11.	Nakano N, Moriguchi A,Morishita R, et al. Role of angiotensinⅡ in the regulation of a novel vascular modulator, hepatocyte growth factor ( HGF) , in experimental hypertensive rats. Hypertension, 1997, 30 :1448-1454.
12.	McNicholas WT. Obstructive sleep apnea and inflammation. Prog Cardiovasc Dis, 2009, 51: 392-399 .
13.	张静, 陈宝元, 韩晋英, 等. 交感神经活性和血管内皮功能在阻塞性睡眠呼吸暂停低通气综合征合并高血压发病机制中的作用. 中华结核和呼吸杂志, 2007, 30: 437-441.

1. 王玮. 阻塞性睡眠呼吸暂停低通气综合征与血管内皮功能紊乱. 中华结核和呼吸杂志, 2008, 31: 650 -652.
2. 王邦宁, 胡泽平, 陈大年, 等. 高血压患者肝细胞生长因子与血管内皮功能的关系及干预研究. 中华高血压杂志, 2007, 15: 219 -222 .
3. 中华医学会呼吸病学分会睡眠呼吸疾病学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南( 草案) . 中华结核和呼吸杂志,2002, 25: 195-198.
4. Stoker M, Gherardi E, Perryman M, et al. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature,1987, 327 : 239-242.
5. Kuhlmann CR, Schaefer CA, Fehsecke A, et al. A new signaling mechanism of hepatocyte growth factor-induced endothelial proliferation. J Thromb Haemost, 2005 , 3: 2089 -2095 .
6. Uruno A, Sugawara A, Kanatsuka H, et al. Hepatocyte growth factor stimulates nitric oxide production through endothelial nitric oxide synthase activation by the phosphoinositide 3-kinase/ Akt pathway and possibly by mitogen-activated protein kinase kinase in vascular endothelial cells. Hypertens Res, 2004, 27: 887-895.
7. 钱瑾邺, 王邦宁. HGF 在高血压和肾素-血管紧张素系统中的研究进展. 山东医药, 2008, 48: 139-140 .
8. Nakamura Y, Morishita R, Nakamura S, et al. A vascular modulator,hepatocyte growth factor, is associated with systolic pressure.Hypertension, 1996, 28 : 409-413 .
9. 陈建英, 杨天伦, 陈灿, 等. 高血压病患者血清肝细胞生长因子与低密度脂蛋白及左室重塑的关系. 中国现代医学杂志, 2003 ,13: 19 -21 .
10. 李萍, 杨庭树. 肝细胞生长因子在心血管疾病诊断及治疗中的应用. 中国康复理论与实践, 2006 , 12 : 966-967.
11. Nakano N, Moriguchi A,Morishita R, et al. Role of angiotensinⅡ in the regulation of a novel vascular modulator, hepatocyte growth factor ( HGF) , in experimental hypertensive rats. Hypertension, 1997, 30 :1448-1454.
12. McNicholas WT. Obstructive sleep apnea and inflammation. Prog Cardiovasc Dis, 2009, 51: 392-399 .
13. 张静, 陈宝元, 韩晋英, 等. 交感神经活性和血管内皮功能在阻塞性睡眠呼吸暂停低通气综合征合并高血压发病机制中的作用. 中华结核和呼吸杂志, 2007, 30: 437-441.

Chinese Journal of Respiratory and Critical Care Medicine

Association Between Serum Level of Hepatocyte Growth Factor and OSAHS with Hypertension

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