Relationship Between Obstructive Sleep Apnea Hypopnea Syndrome and Airway Hyperresponsiveness_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

SHI Ping , XIONG Xiaomin , ZENG Jia , ZHAO Shicai , MA Bing , YANG Ping

Department of Respiratory Medicine, Central Hospital of Guangyuan City. Guangyuan, Sichuan, 628000, ChinaCorresponding Author: SHI Ping, E-mail: gyshiping@ 163. com;

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Keywords：

Obstructive sleep apnea hypopnea syndrome; Airway responsiveness

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Objective To explore the relationship between obstructive sleep apnea hypopnea syndrome ( OSAHS) and airway hyperresponsiveness ( AHR) . Methods 197 subjects suspected for OSAHS were enrolled in the study. They were all performed overnight polysomnogram ( PSG) monitoring and lung function test. Acoording to the results of FEV1% pred, they were performed bronchial provocation test( BPT)or brochial dilation test( BDT) . The relation between apnea hypopnea index ( AHI) and the degree of airway hyperresponsiveness ( AHR, expressed as PD20 -FEV1 ) was evaluated by linear correlation analysis. Results 117 patients were diagnosed as OSAHS, in which 28 cases were complicated with AHR( 3 cases with positive BDT result, 25 cases with AHR) . In 80 non-OSAHS patients, 7 cases were complicated with AHR. The
incidence of AHR was higher in the OSAHS patients compared with the non-OSAHS patients( 23. 9% vs 8. 8% , P lt; 0. 01 ) . AHI of OSAHS patients with AHR was higher than OSAHS patients without AHR[ ( 30. 3 ±5. 1) /h vs ( 23. 7 ±2. 4) /h, P lt;0. 01] . There was a positive correlation between AHI and degree of AHR in OSAHS patients with AHR( r=0. 62, P lt;0. 05, n=25) . Conclusion OSAHS is associated with an increased risk of AHR.

Citation： SHI Ping,XIONG Xiaomin,ZENG Jia,ZHAO Shicai,MA Bing,YANG Ping. Relationship Between Obstructive Sleep Apnea Hypopnea Syndrome and Airway Hyperresponsiveness. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(3): 253-255. doi: Copy

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1. Alkhalil M, Schulman E, Getsy J. Obstructive sleep apnea syndrome and asthma: what are the links? J Clin Sleep Med, 2009, 5 : 71-78.
2. 中华医学会呼吸病学分会睡眠呼吸疾病学组. 阻塞性睡眠呼吸暂停低通气综合征诊治指南( 草案) . 中华结核和呼吸杂志,2002, 25: 195-198 .
3. 朱蕾, 刘又宁, 于润江, 主编. 临床肺功能. 北京: 人民卫生出版社, 2004, 257-260.
4. Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive sumary. Eur Respir J,2008, 31: 143-178 .
5. Denjean A, Roux C, Herve P, et al. Mild isocapnic hypoxia enhances the bronchial response to methacholine in asthmatic subjects. Am Rev Respir Dis, 1988, 138 : 789-793.
6. Valipour A, Makker HK, Hardy R, et al. Symptomatic gastroesophageal reflux in subjects with a breathing sleep disorder.Chest, 2002, 121: 1748 -1753 .
7. Ing AJ, Ngu MC, Breslin AB. Obstructive sleep apnea and gastroesophageal reflux. Am J Med, 2000 , 108 Suppl 4 a: 120S-125S.
8. Gislason T, Janson C, Vermeire P, et al. Respiratory symptoms and nocturnal gastroesophageal reflux: a population-based study of young adults in three European countries. Chest, 2002 , 21: 158-163.
9. Carpagnano GE, Kharitonov SA, Resta O, et al. Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest, 2002, 122: 1162-1167.
10. Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol, 2004, 22 : 789 -815.
11. Devouassoux G, Lévy P, Rossini E, et al. Sleep apnea is associated with bronchial inflammation and continuous positive airway pressure-induced airway hyperresponsiveness. J Allergy Clin Immunol, 2007, 119: 597-603 .

Chinese Journal of Respiratory and Critical Care Medicine

Relationship Between Obstructive Sleep Apnea Hypopnea Syndrome and Airway Hyperresponsiveness

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