Simvastatin Improves Pulmonary Function and Vascular Endothelial Growth Factor Level in Induced Sputum of Patients with COPD Exacerbation_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

XIA Shuyue ¹ , KANG Jian ² , HE Wei ¹ , XU Xiaoyang ¹ , HE Xiaolin ¹ , WANG Shi. ¹

Department of Pulmonary Medicine, Affiliated Fengtian Hospital, Shenyang Medicine College. Senyang, Liaoning, 110024, ChinaCorresponding Author: KANG Jian, E-mail: kangjian58@ 163. com;

Corresponding author：

Keywords：

Chronic obstructive pulmonary disease; Acute exacerbation; Sputum induction; Vascular endothelial growth factor; ; Simvastatin

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Objective To investigate the effects of simvastatin on pulmonary function and vascular endothelial growth factor ( VEGF) levels in induced sputumof patients with COPD exacerbation( AECOPD) .Methods Thirty-eight patients with AECOPD were divided into two groups randomly, ie. a routine medical treatment( RT) group( n =30) and a routine + statin medical treatment( RST) group( n =28) . The VEGF levels in serumand induced sputum were detected by ELISA on the first day and after a week treatment in hospital, respectively. Meanwhile, the pulmonary function measurements were performed. Results There were no significant differences in the pulmonary function ( FEV1% pred and FEV1 /FVC) and VEGF levels in induced sputumbetween the two groups before treatment( P gt;0. 05) . The RT group showed no significant
changes in any parameters before and after a week treatment( P gt; 0. 05) . FEV1% pread, FEV1 /FVC and VEGF levels in induced sputum in the RST group after a week treatment significantly increased compared with those before treatment and the RT group( P lt;0. 01, P lt;0. 01, P lt;0. 05) . But There were no significant differences in serumVEGF levels between the two groups before and after a week treatment. The VEGF levels in induced sputum were positively correlated to FEV1% pread and FEV1 /FVC after a week treatment( r =0. 430, P lt;0. 05; r = 0. 388, P lt; 0. 05) . Conclusions Simvastatin may reduce the decline in pulmonary function and decrease the levels of VEGF in induced sputum of patients with AECOPD. Improvement in pulmonary function may be related to down-expression of lung VEGF

Citation： XIA Shuyue,KANG Jian,HE Wei,XU Xiaoyang,HE Xiaolin,WANG Shi.. Simvastatin Improves Pulmonary Function and Vascular Endothelial Growth Factor Level in Induced Sputum of Patients with COPD Exacerbation. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(3): 295-297. doi: Copy

1.	Mannnino DM, Davis KJ. Lung function decline and outcomes in an elderly populine. Thorax, 2006, 61 : 472-477.
2.	刘春涛, 冯玉麟. 慢性阻塞性肺疾病急性加重期研究进展. 中国呼吸与危重监护杂志, 2007, 6: 413-415.
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6.	Kanazawa H. Role of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease. Med Sci Monit , 2007, 13 : RA189-195.
7.	KasaharaY, Tuder RM, Cool CD, et al. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growthfactor receptor 2 in emphysema. Am J Respir Crit Care Med, 2001, 163: 737-744 .
8.	崔吉香, 夏书月, 毕英, 等. 支气管哮喘和慢性阻塞性肺疾病患者诱导痰中血管内皮生长因子的变化. 中华结核和呼吸杂志,2008, 31: 307.
9.	王悦虹, 白春学, 毛羽, 等. 血管内皮生长因子及其受体在肺气肿患者肺组织中的表达. 中华内科杂志, 2005 , 44: 276-279.
10.	Takahashi S, Nakamurea H, Seki M, et al. Reversal of elastase -induced pulmonary emphysema and promotion of alveolar epithelial cell proliferation by simvastatin in mice. AmJ Physiol Lung Cell Mol Physiol, 2008 , 294: L882-L890 .
11.	Keddissi JI, Younis WG, Chbeir EA, et al. The use of Statins and lung function in current and former smokers. Chest, 2007 , 132 :1764-1771.
12.	Alexeeff SE, Litonjua AA, Sparrow D, et al . Statin use reduces decline in lung function: VA Nomative Aging Study. Am J Respir Crit Care Med, 2007, 176: 742-747.

1. Mannnino DM, Davis KJ. Lung function decline and outcomes in an elderly populine. Thorax, 2006, 61 : 472-477.
2. 刘春涛, 冯玉麟. 慢性阻塞性肺疾病急性加重期研究进展. 中国呼吸与危重监护杂志, 2007, 6: 413-415.
3. Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastation in men with hypercholesterolemia. West of Scotland Coronary Prevention Group. N Engl J Med, 1995, 333 :1301-1307.
4. 中华医学会呼吸病学分会慢性阻塞性肺疾病. 慢性阻塞性肺疾病诊疗指南( 2007 年修订版) . 中华结核和呼吸杂志, 2007, 30 :8-17.
5. Cosio Piqueras MG, Cosio MG. Disease of the airway in chronic obstruction pulmonary disease . Eur Respir J, 2001, 18 Suppl : 41S-49S.
6. Kanazawa H. Role of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease. Med Sci Monit , 2007, 13 : RA189-195.
7. KasaharaY, Tuder RM, Cool CD, et al. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growthfactor receptor 2 in emphysema. Am J Respir Crit Care Med, 2001, 163: 737-744 .
8. 崔吉香, 夏书月, 毕英, 等. 支气管哮喘和慢性阻塞性肺疾病患者诱导痰中血管内皮生长因子的变化. 中华结核和呼吸杂志,2008, 31: 307.
9. 王悦虹, 白春学, 毛羽, 等. 血管内皮生长因子及其受体在肺气肿患者肺组织中的表达. 中华内科杂志, 2005 , 44: 276-279.
10. Takahashi S, Nakamurea H, Seki M, et al. Reversal of elastase -induced pulmonary emphysema and promotion of alveolar epithelial cell proliferation by simvastatin in mice. AmJ Physiol Lung Cell Mol Physiol, 2008 , 294: L882-L890 .
11. Keddissi JI, Younis WG, Chbeir EA, et al. The use of Statins and lung function in current and former smokers. Chest, 2007 , 132 :1764-1771.
12. Alexeeff SE, Litonjua AA, Sparrow D, et al . Statin use reduces decline in lung function: VA Nomative Aging Study. Am J Respir Crit Care Med, 2007, 176: 742-747.

Chinese Journal of Respiratory and Critical Care Medicine

Simvastatin Improves Pulmonary Function and Vascular Endothelial Growth Factor Level in Induced Sputum of Patients with COPD Exacerbation

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