The Lung Cancer Chemoprevention of Inhaled Corticosteroids in COPD Patients_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

NI Yingmeng , SHI Guochao

Department of Respiratory Medicine，Ruijin Hospital，Shanghaijiaotong University.Shanghai 200025,China;

Corresponding author：

Keywords：

Lung Cancer; Chemoprevention; Inhaled Corticosteroids; COPD

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COPD 和肺癌均为最常见的吸烟相关呼吸道疾病。吸入性糖皮质激素( ICS) 近年来被推荐用于重度COPD 的治疗, 同时也被发现在肺癌的化学预防中起重要作用。本文通
过综述ICS、COPD 和肺癌之间的关系, 特别是吸入糖皮质激素在肺癌中的化学预防作用, 以期进一步明确ICS 在COPD和肺癌中的作用。

Citation： NI Yingmeng,SHI Guochao. The Lung Cancer Chemoprevention of Inhaled Corticosteroids in COPD Patients. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(3): 326-328. doi: Copy

1.	彭敏，李龙芸.肺癌的早期诊断.中华内科杂志，2003，42：884-886.
2.	Papi A，Casoni G，Caramori G，et al.COPD increases the risk of squamous histological subtype in smokers who develop non-small cell lung carcinoma.Thorax，2004，59：679-681.
3.	Lung Health Study Research Group.Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease.N Engl J Med，2000，343：1902-1909.
4.	Pitty TL.Are COPD and lung cancer two manifestations of the same disease? Chest，2005，128：1895-1897.
5.	Skillrud DM，Offord KP，Miller RD.Higher risk of lung cancer in chronic obstructive pulmonary disease：a prospective，matched，controlled study.Ann Intern Med，1986，105：503-507.
6.	Pashko LL，Schwartz AG.Inhibition of 7，12-dimethylbenz[a]anthracene-induced lung tumorigenesis in A/J mice by food restriction is reversed by adrenalectomy.Carcinogenesis，1996，17：209-212.
7.	Wattenberg LW，Estensen RD.Chemopreventive effects of myo-inositol and dexamethasone on benzo[a]pyrene and 4-（methylnitrosoamino）-1-（3-pyridyl）-1-butanone-induced pulmonary carcinogenesis in female A/J mice.Cancer Res，1996，56：5132-5135.
8.	Pereira MA，Li YZ，Gunning WT，et al.Prevention of mouse lung tumors by budesonide and its modulation of biomarkers.Carcinogenesis，2002，23：1185-1192.
9.	Wattenberg LW，Wiedmann TS，Estensen RD，et al.Chemoprevention of pulmonary carcinogenesis by aeosolized budesonide in female A/J mice.Cancer Res，1997，57：5489-5492.
10.	Wattenberg LW，Wiedmann TS，Estensen RD，et al.Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol.Carcinogenesis，2000，21：179-182.
11.	Lipkin M.Biomarkers of increased susceptibility to gastrointestinal cancer：new application to studies of cance prevention in human subjects.Cancer Res，1988，48：235-245.
12.	Estensen RD，Jordan MM，Wiedmann TS，et al.Effect of chemoprevetive agents on separate stages of progression of benzo[a]pyrene induced lung tumors in A/J mice.Carcinogenesis，2004，25：197-201.
13.	Parimon T，Chien JW，Bryson CL，et al.Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease.Am J Respir Crit Care Med，2007，175：712-719.
14.	Miller YE，Keith RL.Inhaled corticosteroids and lung cancer chemoprevention.Am J Respir Crit Care Med，2007，175：636-637.
15.	Lam S，leRiche JC，McWilliams A，et al.A randomized phase IIb Trial of pulmicort turbuhaler（budesonide） in people with dysplasia of the bronchial epithelium.Clin Cancer Res，2004，10：6502-6511.
16.	Keith BD.Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy.BMC Cancer，2008，8：84.
17.	Brody JS，Spira A.State of the art.Chronic obstructive pulmonary disease，inflammation，and lung cancer.Proc Am Thorac Soc，2006，3：535-537.
18.	Pages V，Fuchs RP.How DNA lesions are turned into mutations within cells? Oncogene，2002，21：8957-8966.
19.	Barnes PJ.How corticosteroids control inflammation.Br J Pharmacol，2006，148：245-254.
20.	John M，Au BT，Jose PJ，et al.Expression and release of interleukin-8 by human airway smooth muscle cells：inhibition by Th-2 cytokines and corticosteroids.Am J Respir Cell Mol Biol，1998，18：84-90.
21.	Wissink S，van Heerde EC，vand der Burg B，et al.A dual mechanism mediates repression of NF-kappaB activity by glucocorticoids.Mol Endocrinol，1998，12：355-363.
22.	Pereira MA，Tao LH，Wang W，et al.Chemoprevention：mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker.Exp Lung Res，2005，31：145-163.
23.	Counts JL，Goodman JI.Hypomethylation of DNA：a possible epigenetic mechanism involved in tumor promotion.Prog Clin Biol Res，1995，391：81-101.
24.	Li L，Tao LH，Lubet RA，et al.Modulation by budesonide of a CpG endonuclease in mouse lung tumors.Carcinogenesis，2007，28：1499-1503.
25.	Alyaqoub FS，Tao LH，Kramer PM，et al.Prevention of mouse lung tumors and modulation of DNA methylation by combinedtreatment with budesonide and R115777 （ZarnestraMT）.Carcinogenesis，2006，27：2442-2447.
26.	Greenberg AK，Hu J，Basu S，et al.Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators.Am J Respir Cell Mol Biol，2002，27：320-328.
27.	Kassel O，Sancono A，Krätzschmar J，et al.Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1.EMBO J，2001，20：7108-7116.

1. 彭敏，李龙芸.肺癌的早期诊断.中华内科杂志，2003，42：884-886.
2. Papi A，Casoni G，Caramori G，et al.COPD increases the risk of squamous histological subtype in smokers who develop non-small cell lung carcinoma.Thorax，2004，59：679-681.
3. Lung Health Study Research Group.Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease.N Engl J Med，2000，343：1902-1909.
4. Pitty TL.Are COPD and lung cancer two manifestations of the same disease? Chest，2005，128：1895-1897.
5. Skillrud DM，Offord KP，Miller RD.Higher risk of lung cancer in chronic obstructive pulmonary disease：a prospective，matched，controlled study.Ann Intern Med，1986，105：503-507.
6. Pashko LL，Schwartz AG.Inhibition of 7，12-dimethylbenz[a]anthracene-induced lung tumorigenesis in A/J mice by food restriction is reversed by adrenalectomy.Carcinogenesis，1996，17：209-212.
7. Wattenberg LW，Estensen RD.Chemopreventive effects of myo-inositol and dexamethasone on benzo[a]pyrene and 4-（methylnitrosoamino）-1-（3-pyridyl）-1-butanone-induced pulmonary carcinogenesis in female A/J mice.Cancer Res，1996，56：5132-5135.
8. Pereira MA，Li YZ，Gunning WT，et al.Prevention of mouse lung tumors by budesonide and its modulation of biomarkers.Carcinogenesis，2002，23：1185-1192.
9. Wattenberg LW，Wiedmann TS，Estensen RD，et al.Chemoprevention of pulmonary carcinogenesis by aeosolized budesonide in female A/J mice.Cancer Res，1997，57：5489-5492.
10. Wattenberg LW，Wiedmann TS，Estensen RD，et al.Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol.Carcinogenesis，2000，21：179-182.
11. Lipkin M.Biomarkers of increased susceptibility to gastrointestinal cancer：new application to studies of cance prevention in human subjects.Cancer Res，1988，48：235-245.
12. Estensen RD，Jordan MM，Wiedmann TS，et al.Effect of chemoprevetive agents on separate stages of progression of benzo[a]pyrene induced lung tumors in A/J mice.Carcinogenesis，2004，25：197-201.
13. Parimon T，Chien JW，Bryson CL，et al.Inhaled corticosteroids and risk of lung cancer among patients with chronic obstructive pulmonary disease.Am J Respir Crit Care Med，2007，175：712-719.
14. Miller YE，Keith RL.Inhaled corticosteroids and lung cancer chemoprevention.Am J Respir Crit Care Med，2007，175：636-637.
15. Lam S，leRiche JC，McWilliams A，et al.A randomized phase IIb Trial of pulmicort turbuhaler（budesonide） in people with dysplasia of the bronchial epithelium.Clin Cancer Res，2004，10：6502-6511.
16. Keith BD.Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy.BMC Cancer，2008，8：84.
17. Brody JS，Spira A.State of the art.Chronic obstructive pulmonary disease，inflammation，and lung cancer.Proc Am Thorac Soc，2006，3：535-537.
18. Pages V，Fuchs RP.How DNA lesions are turned into mutations within cells? Oncogene，2002，21：8957-8966.
19. Barnes PJ.How corticosteroids control inflammation.Br J Pharmacol，2006，148：245-254.
20. John M，Au BT，Jose PJ，et al.Expression and release of interleukin-8 by human airway smooth muscle cells：inhibition by Th-2 cytokines and corticosteroids.Am J Respir Cell Mol Biol，1998，18：84-90.
21. Wissink S，van Heerde EC，vand der Burg B，et al.A dual mechanism mediates repression of NF-kappaB activity by glucocorticoids.Mol Endocrinol，1998，12：355-363.
22. Pereira MA，Tao LH，Wang W，et al.Chemoprevention：mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker.Exp Lung Res，2005，31：145-163.
23. Counts JL，Goodman JI.Hypomethylation of DNA：a possible epigenetic mechanism involved in tumor promotion.Prog Clin Biol Res，1995，391：81-101.
24. Li L，Tao LH，Lubet RA，et al.Modulation by budesonide of a CpG endonuclease in mouse lung tumors.Carcinogenesis，2007，28：1499-1503.
25. Alyaqoub FS，Tao LH，Kramer PM，et al.Prevention of mouse lung tumors and modulation of DNA methylation by combinedtreatment with budesonide and R115777 （ZarnestraMT）.Carcinogenesis，2006，27：2442-2447.
26. Greenberg AK，Hu J，Basu S，et al.Glucocorticoids inhibit lung cancer cell growth through both the extracellular signal-related kinase pathway and cell cycle regulators.Am J Respir Cell Mol Biol，2002，27：320-328.
27. Kassel O，Sancono A，Krätzschmar J，et al.Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1.EMBO J，2001，20：7108-7116.

Chinese Journal of Respiratory and Critical Care Medicine

The Lung Cancer Chemoprevention of Inhaled Corticosteroids in COPD Patients

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