Relationship Between Disease Severity and Life Quality in Patients with Chronic Obstructive Pulmonary Disease_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

YANG Fan ¹ , HUO Jianmin ¹ , WANG Dongjie ¹ , WANG Jian ²

First Clinical College of Harbin Medical University. Harbin, Heilongjiang, 150001, ChinaCorresponding Author: HUO Jian-min, E-mail: hjm28k@ yahoo. com. cn;

Corresponding author：

Keywords：

Chronic obstructive pulmonary disease; BODE index; Quality of life; St George’s respiratory questionnaire

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Objective To compare BODE index with GOLD staging for the severity evaluation in patients with chronic obstructive pulmonary disease ( COPD) . To investigate the relationship between BODE index and quality of life. Methods A total of 100 patients with stable COPD were enrolled. All participants were examined with lung function test and St George’s Respiratory Questionnaire ( SGRQ) for evaluation of quality of life. BODE index and it’s four components including body mass index( BMI) , airflow obstruction ( FEV1%pred) , dyspnea( MMRC) , and exercise capacity( 6MWD) were calculated. The participants were divided into four groups of severity using GOLD guidelines and BODE index quartiles. Results The associations between SGRQ total score and SGRQ subscales, and BODE index were significant( P lt;0. 01) .
BODE index was a significant predictor of the quality of life, explaining 41. 3% of the total score of the SGRQ ( P lt;0. 01) . However, GOLD classification showed a correlation only with SGRQ activity score ( P lt;0. 05) but not with other SGRQ scores. There were significant differences in SGRQ total score and SGRQ
subscales between different severity groups of BODE index( P lt;0. 01) . But there was no difference in SGRQ score between different severity groups of GOLD classification, except SGRQ activity score. Conclusion BODE scoring system is better correlated with the quality of life as assessed by the disease severity in
patients with COPD than the GOLD staging criteria.

Citation： YANG Fan,HUO Jianmin,WANG Dongjie,WANG Jian. Relationship Between Disease Severity and Life Quality in Patients with Chronic Obstructive Pulmonary Disease. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(5): 471-475. doi: Copy

1.	Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI /WHO Global Initiative for Chronic Obstructive Lung Disease ( GOLD ) Workshop summary. Am J Respir Crit Care Med, 2001, 163: 1256 -1276 .
2.	Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet, 1997, 349: 1269 -1276.
3.	徐鸥, 郝青林, 李锐洁, 等. 圣乔治呼吸问卷对慢性塞性肺疾病患者生活质量差异的调查. 昆明医学院学报, 2008, 29: 71-75.
4.	Cel1 i BR, Cote CG, Marin JM, et al. The body-mass index, airflow obstruction, dyspnea and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med, 2004, 350: 1005 -1012.
5.	Medinas Amorós M, Mas-Tous C, Renom-Sotorra F, et al. Healthrelated quality of life is associated with COPD severity: a comparison between the GOLD staging and the BODE index. Chron Respir Dis, 2009, 6 : 75-80.
6.	中华医学会呼吸病学分会慢性阻塞性肺疾病组. 慢性阻塞性肺疾病诊治指南. 中华结核和呼吸杂志, 2002, 25: 453 -459.
7.	Celli BR, MacNee W, Arusti A, et al. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J, 2004, 23: 932-946 .
8.	Jone PW, Quirk FH, Baveystock CM, et al. The St George′s Respiratory Questionnaire. Respir Med, 1991, 85 : 25-31.
9.	Mahler DA, Weinberg DH, Wells CK, et al. The measurement of dyspnea: contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest, 1984 , 85: 751-758.
10.	Ozalevli S, Ozden A, Itil O, et al. Comparison of the Sit-to-Stand Test with 6min walk test in patients with chronic obstructive pulmonary disease. Respir Med, 2007, 101: 286 -293.
11.	Jones PW, Quirk FH, Baveystock CM, et al. A self-complete measure of health status for chronic airflow limitation: the St.George’s respiratory questionnaire. Am Rev Respir Dis, 1992, 145 :1321-1327.
12.	Alsaeedi A, Sin DD, McAlister FA, et al. The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials. Am J Med, 2002, 113: 59-65.
13.	O′Donnell DE, Lam M, Webb KA, et al. Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. AmJ Respir Crit Care Med,1998, 158: 1557-1565.
14.	Stephen I. Looking at the patient: approaching the problem of COPD. N Engl J Med, 2004, 350 : 965-966.
15.	Katsura H, Yamada K, Kida K, et al. Both generic and disease specific health-related quality of life are deteriorated in patients with underweight COPD. Respir Med, 2005, 99: 624 -630.
16.	Nishimura K, Lzumi T, Tsukino M, et al. Dyspnea is better predictor of 5-year survival than airway obstructive in patients with COPD.Chest, 2002, 121: 1434 -1440 .
17.	雷玲, 钟小宁, 何志义. 慢性阻塞性肺疾病患者BODE 指数与生活质量的相关性研究. 中国呼吸与危重监护杂志, 2007, 6 : 261 -264.
18.	Cote CG, Dordelly LJ, Celli BR, et al. Impact of exacerbations on patient-centered outcomes. Chest, 2007 , 131: 696-704 .

1. Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI /WHO Global Initiative for Chronic Obstructive Lung Disease ( GOLD ) Workshop summary. Am J Respir Crit Care Med, 2001, 163: 1256 -1276 .
2. Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet, 1997, 349: 1269 -1276.
3. 徐鸥, 郝青林, 李锐洁, 等. 圣乔治呼吸问卷对慢性塞性肺疾病患者生活质量差异的调查. 昆明医学院学报, 2008, 29: 71-75.
4. Cel1 i BR, Cote CG, Marin JM, et al. The body-mass index, airflow obstruction, dyspnea and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med, 2004, 350: 1005 -1012.
5. Medinas Amorós M, Mas-Tous C, Renom-Sotorra F, et al. Healthrelated quality of life is associated with COPD severity: a comparison between the GOLD staging and the BODE index. Chron Respir Dis, 2009, 6 : 75-80.
6. 中华医学会呼吸病学分会慢性阻塞性肺疾病组. 慢性阻塞性肺疾病诊治指南. 中华结核和呼吸杂志, 2002, 25: 453 -459.
7. Celli BR, MacNee W, Arusti A, et al. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J, 2004, 23: 932-946 .
8. Jone PW, Quirk FH, Baveystock CM, et al. The St George′s Respiratory Questionnaire. Respir Med, 1991, 85 : 25-31.
9. Mahler DA, Weinberg DH, Wells CK, et al. The measurement of dyspnea: contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest, 1984 , 85: 751-758.
10. Ozalevli S, Ozden A, Itil O, et al. Comparison of the Sit-to-Stand Test with 6min walk test in patients with chronic obstructive pulmonary disease. Respir Med, 2007, 101: 286 -293.
11. Jones PW, Quirk FH, Baveystock CM, et al. A self-complete measure of health status for chronic airflow limitation: the St.George’s respiratory questionnaire. Am Rev Respir Dis, 1992, 145 :1321-1327.
12. Alsaeedi A, Sin DD, McAlister FA, et al. The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials. Am J Med, 2002, 113: 59-65.
13. O′Donnell DE, Lam M, Webb KA, et al. Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. AmJ Respir Crit Care Med,1998, 158: 1557-1565.
14. Stephen I. Looking at the patient: approaching the problem of COPD. N Engl J Med, 2004, 350 : 965-966.
15. Katsura H, Yamada K, Kida K, et al. Both generic and disease specific health-related quality of life are deteriorated in patients with underweight COPD. Respir Med, 2005, 99: 624 -630.
16. Nishimura K, Lzumi T, Tsukino M, et al. Dyspnea is better predictor of 5-year survival than airway obstructive in patients with COPD.Chest, 2002, 121: 1434 -1440 .
17. 雷玲, 钟小宁, 何志义. 慢性阻塞性肺疾病患者BODE 指数与生活质量的相关性研究. 中国呼吸与危重监护杂志, 2007, 6 : 261 -264.
18. Cote CG, Dordelly LJ, Celli BR, et al. Impact of exacerbations on patient-centered outcomes. Chest, 2007 , 131: 696-704 .

Chinese Journal of Respiratory and Critical Care Medicine

Relationship Between Disease Severity and Life Quality in Patients with Chronic Obstructive Pulmonary Disease

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