肺癌患者血清生长激素释放肽和瘦素的水平变化及意义_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

徐春华 , 于力克 , 张宇

Corresponding author：

Keywords：

肺癌; 生长激素释放肽; 瘦素

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的探讨肺癌患者血清生长激素释放肽和瘦素水平的变化及意义。方法应用放射免疫分析法和酶联免疫吸附法( ELISA) 测定46 例肺癌患者血清中生长激素释放肽和瘦素水平的变化, 并与30 例正常健康人作比较。结果肺癌患者血清生长激素释放肽和瘦素水平均高于正常人( P lt;0. 01) , 且两者呈正相关性。结论检测肺癌患者血清生长激素释放肽和瘦素水平的变化对疾病的监测具有重要的临床价值。

Citation： 徐春华,于力克,张宇. 肺癌患者血清生长激素释放肽和瘦素的水平变化及意义. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(5): 537-538. doi: Copy

1.	Kojima M, Hosoda H, Date Y, et al. Ghrelinis agrowth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660 .
2.	Wallace AM, Sattar N, McMillan DC. Efect ofweight loss and the inflammatory response Oil leptin concentrations in gastrointestinal cancer patients. Clin Cancer Res, 1998, 4 : 2977-2979.
3.	任珂明, 厉有名. Ghrelin 及其受体在肿瘤发生中的作用. 国外医学· 老年医学分册, 2006, 27 : 196-200.
4.	Vivenza D, Rapa A, Castellino N, et al. Ghrelin gone polymorphisms and ghrelin, insulin, IGF-1 , leptin and anthmpometric data in children and adolescents. Eur J Endocrinol, 2004, 151: 127 -133.
5.	Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660.
6.	Date Y, Nakazato M, Hashiguchi S, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes, 2002, 51: 124 -129.
7.	Smith RG, Van der Ploeg LH, Howard AD, et al. Peptidomimetic regulation ofgrowth hormone secretion. Endocr Rev, 1997, 18: 621 -645.
8.	Mckee KK, Palyha OC, Feiner SD, et al. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.Mol Endocrino1, 1997, 11 : 415-423.
9.	Shuto Y, Shibasaki T, Wada K, et al. Generation of polyclonal antiserumagainst the growth hormone secretagogue receptor( GHSR): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach ofrats. Life Sci, 2001, 68: 991 -996.
10.	Cassoni P, Allia E, Marrocco T, et al. Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line. J Endocrinol Invest, 2006, 29: 781 -790.
11.	Shimizu Y, Nagaya N, Isobe T, et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res, 2003 , 9: 774-778 .
12.	Maninez V, Barrachlna MD, Wang L, et al. Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats.Neumreport, 1999, 10: 3217-3221.

1. Kojima M, Hosoda H, Date Y, et al. Ghrelinis agrowth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660 .
2. Wallace AM, Sattar N, McMillan DC. Efect ofweight loss and the inflammatory response Oil leptin concentrations in gastrointestinal cancer patients. Clin Cancer Res, 1998, 4 : 2977-2979.
3. 任珂明, 厉有名. Ghrelin 及其受体在肿瘤发生中的作用. 国外医学· 老年医学分册, 2006, 27 : 196-200.
4. Vivenza D, Rapa A, Castellino N, et al. Ghrelin gone polymorphisms and ghrelin, insulin, IGF-1 , leptin and anthmpometric data in children and adolescents. Eur J Endocrinol, 2004, 151: 127 -133.
5. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature, 1999, 402: 656 -660.
6. Date Y, Nakazato M, Hashiguchi S, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes, 2002, 51: 124 -129.
7. Smith RG, Van der Ploeg LH, Howard AD, et al. Peptidomimetic regulation ofgrowth hormone secretion. Endocr Rev, 1997, 18: 621 -645.
8. Mckee KK, Palyha OC, Feiner SD, et al. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.Mol Endocrino1, 1997, 11 : 415-423.
9. Shuto Y, Shibasaki T, Wada K, et al. Generation of polyclonal antiserumagainst the growth hormone secretagogue receptor( GHSR): evidence that the GHS-R exists in the hypothalamus, pituitary and stomach ofrats. Life Sci, 2001, 68: 991 -996.
10. Cassoni P, Allia E, Marrocco T, et al. Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line. J Endocrinol Invest, 2006, 29: 781 -790.
11. Shimizu Y, Nagaya N, Isobe T, et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res, 2003 , 9: 774-778 .
12. Maninez V, Barrachlna MD, Wang L, et al. Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats.Neumreport, 1999, 10: 3217-3221.

Chinese Journal of Respiratory and Critical Care Medicine

肺癌患者血清生长激素释放肽和瘦素的水平变化及意义

Abstract Full text Figures/Tables Video References Cited by

Format

Content