Initial Resistance of Mycobacterium tuberculosis in Patients with Culture Positive Pulmonary Tuberculosis_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

GUO Xinmei , CHI Jingyu , LI Wogen , ZHANG Linlin , YANG Lei , WANG Haiying , WANG Yan

Shandong Provincial Chest Hospital. Ji’nan, Shandong, 250013, ChinaCorresponding Author: GUO Xin-mei, E-mail: xkyy1997@ 163. com;

Corresponding author：

Keywords：

Mycobacterium tuberculosis; Drug resistance; Pulmonary tuberculosis

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the initial drug resistance of Mycobacterium tuberculosis ( M.tuberculosis) in patients with culture positive pulmonary tuberculosis. Methods 1184 patients who hospitalized in Shandong Provincial Chest Hospital with culture positive pulmonary tuberculosis were enrolled. The absolute density method was used to assess the drug resistance of M. tuberculosis. Results M.tuberculosis were sensitive to all anti-tuberculosis drugs in 834 cases( 70. 44% ) , and resistant in 350 cases( 29. 56% ) , in which initial resistance and secondary resistance accounted for 44. 86% ( 157/350) and 55. 14% ( 193 /350) respectively. In 157 cases with initial resistance, 53 cases ( 33. 8% ) were mono-drug resistant tuberculosis( MonoDR-TB) , of which 38 cases were resistance to Streptomycin( 24. 2% ) ; 72 cases
( 45. 9% ) were polydrug-resistant tuberculosis ( PDR-TB) ; 20 cases ( 12. 7% ) were multidrug-resistant tuberculosis ( MDR-TB) ; 12 cases ( 7. 6% ) were extensively drug resistant tuberculosis ( XDR-TB) . There was no totally drug-resistant tuberculosis ( TDR-TB) . Conclusions The initial drug resistance of M.tuberculosis in patients with pulmonary tuberculosis is still serious. Unified management of TB control programs and full supervision of chemotherapy are very imperative.

Citation： GUO Xinmei,CHI Jingyu,LI Wogen,ZHANG Linlin,YANG Lei,WANG Haiying,WANG Yan. Initial Resistance of Mycobacterium tuberculosis in Patients with Culture Positive Pulmonary Tuberculosis. Chinese Journal of Respiratory and Critical Care Medicine, 2010, 9(6): 587-590. doi: Copy

1.	唐神结. 耐药结核病防治手册. 北京: 人民卫生出版社, 2009, 13.
2.	Ann M. Loeffler, MD. 耐药结核病: 临床医生使用指南. 第2 版. 中国疾病预防控制中心结核病防治临床中心, 中华医学会结核病学分会, 世界卫生组织结核病研究培训合作中心翻译、出版,2007, 1 -11.
3.	白丽琼, 肖水源. 我国结核病控制中存在的主要问题及对策. 中国卫生事业管理, 2001, 11 : 694-696.
4.	李国利. 结核分枝杆菌耐药分子机制及耐药基因检测方法研究进展. 中国医师杂志, 2002, 4: 338-340.
5.	Herrera L, Valverde A, Saiz P, et al. Molecular characterization of isoniazid-resistantMycobacterium tuberculosisclinical strains isolated in the Philippines. Int J Antimicrob Agents, 2004, 23: 572-576.
6.	Johnson R, Streicher EM, Louw GE, et al. Drug resistance in Mycobacterium tuberculosis. Curr Issues Mol Biol, 2006 , 8: 97-111.
7.	Brown TJ, Herrera-Leon L, Anthony RM, et al. The use of macroarrays for the identification of MDRMycobacteriumtuberculosis. J Microbiol Methods, 2006, 65: 294-300 .
8.	乐军, 刘丽蓉, 谢建平, 等. 异烟肼耐药和敏感结核分枝杆菌的比较蛋白质组学研究. 中华微生物学和免疫学杂志, 2004, 24 : 258 -262.
9.	Rastogi N. Emergence of multidrug-resistance tuberculosis fundamental and applied research aspects global issues and current strategies. Respir Microbiol, 1993, 144: 103 -158.

1. 唐神结. 耐药结核病防治手册. 北京: 人民卫生出版社, 2009, 13.
2. Ann M. Loeffler, MD. 耐药结核病: 临床医生使用指南. 第2 版. 中国疾病预防控制中心结核病防治临床中心, 中华医学会结核病学分会, 世界卫生组织结核病研究培训合作中心翻译、出版,2007, 1 -11.
3. 白丽琼, 肖水源. 我国结核病控制中存在的主要问题及对策. 中国卫生事业管理, 2001, 11 : 694-696.
4. 李国利. 结核分枝杆菌耐药分子机制及耐药基因检测方法研究进展. 中国医师杂志, 2002, 4: 338-340.
5. Herrera L, Valverde A, Saiz P, et al. Molecular characterization of isoniazid-resistantMycobacterium tuberculosisclinical strains isolated in the Philippines. Int J Antimicrob Agents, 2004, 23: 572-576.
6. Johnson R, Streicher EM, Louw GE, et al. Drug resistance in Mycobacterium tuberculosis. Curr Issues Mol Biol, 2006 , 8: 97-111.
7. Brown TJ, Herrera-Leon L, Anthony RM, et al. The use of macroarrays for the identification of MDRMycobacteriumtuberculosis. J Microbiol Methods, 2006, 65: 294-300 .
8. 乐军, 刘丽蓉, 谢建平, 等. 异烟肼耐药和敏感结核分枝杆菌的比较蛋白质组学研究. 中华微生物学和免疫学杂志, 2004, 24 : 258 -262.
9. Rastogi N. Emergence of multidrug-resistance tuberculosis fundamental and applied research aspects global issues and current strategies. Respir Microbiol, 1993, 144: 103 -158.

Chinese Journal of Respiratory and Critical Care Medicine

Initial Resistance of Mycobacterium tuberculosis in Patients with Culture Positive Pulmonary Tuberculosis

Abstract Full text Figures/Tables Video References Cited by

Format

Content