Management of Asthma：Update 2009-2010_Chinese Journal of Respiratory and Critical Care Medicine

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WANG CHangzheng

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Keywords：

Asthma; Management

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目前哮喘的治疗已经取得了显著的进步, 大多数哮喘按全球哮喘防治创议( GINA) 推荐的治疗方案进行规范治疗都可以获得良好的临床控制, 但仍有部分中重度患者难以获得良好的临床控制, 所以仍有必要探索针对这一部分哮喘人群的更好的干预措施。

Citation： WANG CHangzheng. Management of Asthma：Update 2009-2010. Chinese Journal of Respiratory and Critical Care Medicine, 2011, 10(1): 1-2. doi: Copy

1.	Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med, 2009, 360 : 985-993.
2.	Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med, 2009,360: 973-984 .
3.	Wenzel SE, Barnes PJ, Bleecker ER, et al. A randomized, doubleblind,placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med,2009, 179 : 549-558.
4.	Corren J, Busse W, Meltzer EO, et al. A Randomized, Controlled,Phase 2 Study of AMG 317 , an IL-4RαAntagonist, in Patients with Asthma. Am J Respir Crit Care Med, 2010, 181: 788-796.
5.	DiMango E, Holbrook JT, Simpson E, et al. Effects of asymptomatic proximal and distal gastroesophageal reflux on asthma severity. Am J Respir Crit Care Med, 2009 , 180: 809-816.
6.	American Lung Association Asthma Clinical Research Centers,Mastronarde JG, Anthonisen NR, et al. Efficacy of esomeprazole fortreatment of poorly controlled asthma. N Engl J Med, 2009, 360 :1487-1499.
7.	Denning DW, O’Driscoll BR, Powell G, et al. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial ( FAST) Study.Am J Respir Crit Care Med, 2009, 179 : 11-18.
8.	Castro M, Rubin AS, Laviolette M, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma. AmJRespir Crit Care Med, 2010, 181: 116-124.
9.	Peters SP, Kunselman SJ, Icitovic N, et al. Tiotropium bromide stepup therapy for adults with uncontrolled asthma. N Engl J Med, 2010 ,363: 1715 -1726 .

1. Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med, 2009, 360 : 985-993.
2. Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med, 2009,360: 973-984 .
3. Wenzel SE, Barnes PJ, Bleecker ER, et al. A randomized, doubleblind,placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med,2009, 179 : 549-558.
4. Corren J, Busse W, Meltzer EO, et al. A Randomized, Controlled,Phase 2 Study of AMG 317 , an IL-4RαAntagonist, in Patients with Asthma. Am J Respir Crit Care Med, 2010, 181: 788-796.
5. DiMango E, Holbrook JT, Simpson E, et al. Effects of asymptomatic proximal and distal gastroesophageal reflux on asthma severity. Am J Respir Crit Care Med, 2009 , 180: 809-816.
6. American Lung Association Asthma Clinical Research Centers,Mastronarde JG, Anthonisen NR, et al. Efficacy of esomeprazole fortreatment of poorly controlled asthma. N Engl J Med, 2009, 360 :1487-1499.
7. Denning DW, O’Driscoll BR, Powell G, et al. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial ( FAST) Study.Am J Respir Crit Care Med, 2009, 179 : 11-18.
8. Castro M, Rubin AS, Laviolette M, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma. AmJRespir Crit Care Med, 2010, 181: 116-124.
9. Peters SP, Kunselman SJ, Icitovic N, et al. Tiotropium bromide stepup therapy for adults with uncontrolled asthma. N Engl J Med, 2010 ,363: 1715 -1726 .

Chinese Journal of Respiratory and Critical Care Medicine

Management of Asthma：Update 2009-2010

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