【Abstract】 Objective  To observe the plasma levels of adiponectin and interleukin-17 ( IL-17) in patients with chronic obstructive pulmonary disease ( COPD) at acute exacerbation or stable stage, and analyze their relationship. Methods  Sixty male COPD patients with normal weight ( with BMI range of 18. 5-24. 9 kg/m2 ) were enrolled, including 30 patients with acute exacerbations of COPD ( AECOPD) and 30 patients with stable COPD. Twenty healthy nonsmoking male volunteers were included as controls. The plasma levels of adiponectin and IL-17 as well as lung function ( FEV1% pred and RV% pred) were measured in all subjects. Results  The concentrations of adiponectin and IL-17 were significantly higher in the AECOPD patients than those of the patients with stable COPD and the contro1s ( P  lt; 0. 001) . The
concentrations of adiponectin and IL-17 were significantly higher in the patients with stable COPD than those of the controls ( P  lt;0. 01) . Adiponectin was positively correlated with IL-17 in the AECOPD patients ( r =0. 822, P  lt;0. 001) and in the patients with stable COPD ( r =0. 732, P  lt;0. 001) . Adiponectin was positively
correlated with RV% pred in the AECOPD patients ( rs = 0. 764, P  lt;0. 001) and in the patients with stable COPD ( rs =0. 967, P  lt;0. 001) . There was no significant relationship between adiponectin and FEV1% pred ( P  gt;0. 05) . Conclusions  The plasma level of adiponectin in COPD patients is elevated which is related
with excessive inflation of lung. Adiponectin may be involved in the process of inflammation in COPD as a new pro-inflammatory cytokine.

Citation： XIE Juan,DENG Xingqi,LONG Wei,SHI Jindong,HE Mingzhen. Plasma Level of Adiponectin and Its Relationship with Interleukin-17 in Patients with COPD. Chinese Journal of Respiratory and Critical Care Medicine, 2011, 10(1): 21-24. doi: Copy