DENG Jia , CHENHong , TANG Yongjiang , LIANG Binmiao , FENG Yulin.
  • West ChinaHospital, Sichuan University. Chengdu, Sichuan,610041, ChinaCorresponding Author: FENG Yu-lin, E-mail: feng_yulin@ sina. com;
Procalcitonin; Intensive care unit; Severe infection; Antibiotics; Meta analysis
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Objective  To evaluate systematically the effectiveness and safety of procalcitonin ( PCT) -guided therapy in comparison with standard therapy in patients with suspected or confirmed severe bacterial infections in intensive care unit ( ICU) . Methods  Five randomized controlled trials ( 927 patients) were included for statistical analysis by the cochrane collaboration′s RevMan5. 0 software. Results  PCT-guided therapy was associated with a significant reduction in duration of antibiotic therapy [ MD =
- 2. 01, 95% CI ( - 2. 37, - 1. 64) , P  lt;0. 00001] , but the mortality [ OR =1. 11, 95% CI ( 0. 83, 1. 49) ,P =0. 47] and length of ICU stay[ MD = 0. 49, 95% CI( - 1. 44, 2. 42) , P = 0. 62] were not significantly different. Conclusions  An algorithmbased on serial PCT measurements would allow a more judicious use of antibiotics than currently traditional treatment of patients with severe infections in ICU. It can reduce the use of antibiotics and appears to be safe.

Citation： DENG Jia,CHENHong,TANG Yongjiang,LIANG Binmiao,FENG Yulin.. Meta-Analysis of Procalcitonin-Guided Antibiotics Therapy in Patients with Severe Bacterial Infections in ICU. Chinese Journal of Respiratory and Critical Care Medicine, 2011, 10(2): 176-180. doi: Copy