GAN Qing 1 , QI Zhanzhong 2 , ZHAO Fusheng 3 , YANG Lian 4 , WANG Xinping 2 , XIAO Xingqiong 2 , CHEN Qiuling 2 , LI Guangqing 2 , ZHANG Qiong 2
  • Department of Emergency, The 452nd Military Hospital of China. Chengdu, Sichuan, 610041, China Corresponding Author: GAN Qing, E-mail:1350566863@ qq. com;
Asthma; Gene polymorphism; High-affinity IgE receptor βchain; Meta-analysis
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Objective  To investigate the association between the -6843G/A polymorphism of highaffinity IgE receptor βchain ( FcεRIβ) gene and asthma susceptibility in Chinese population.
Methods  We searched Pubmed, EMBASE, CNKI ( Chinese National Knowledge Infrastructure) , Wanfang Datebase, VIP Database up to October 1,2009. Statistical analysis was performed with the software program RevMan 4. 2. 8 and STATA 10. 0.
Results  A total of 9 case-control studies were included in the meta-analysis. The results indicated that the G allele carriers had a 49% increased risk of asthma in Chinese population ( GG + GA vs. AA: OR=1. 49, 95% CI 1. 01-2. 22) . In the subgroup analysis, the results indicated that the polymorphism was associated with increased risk of asthma in the adults ( GG + GA vs. AA: OR = 1. 83, 95% CI 1. 32- 2. 52) , but not in children ( GG + GA vs. AA: OR = 1. 19, 95% CI 0. 68-2. 08) .
Conclusion  The -6843G/A polymorphism of FcεRIβ gene is associated with increased asthma susceptibility in Chinese population.

Citation： GAN Qing,QI Zhanzhong,ZHAO Fusheng,YANG Lian,WANG Xinping,XIAO Xingqiong,CHEN Qiuling,LI Guangqing,ZHANG Qiong. The -6843G /A Polymorphismof High-Affinity IgE Receptor βChainGene and Asthma Susceptibility in Chinese Population: A Meta-Analysis. Chinese Journal of Respiratory and Critical Care Medicine, 2011, 10(4): 321-324. doi: Copy