GUO Lu 1 , XIE Zhengliang 2 , LIU Yuejian 2 , LI Chunmei 3 , LI Weimin 1
  • Department of Respiratory Medicine, West China Hospital, Sichuan University. Chengdu, Sichuan, 610041, ChinaCorresponding Author: XIE Zheng-liang, E-mail: xiezhliang2004@ yahoo. com. cn;
Chronic obstructive pulmonary disease; Atherosclerosis; Risk factors; Carotid intima-media thickness
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Objective  To evaluate the relationship between COPD and atherosclerosis, and analyze the risk factors of atherosclerosis among COPD patients.
Methods  A total of 40 COPD patients and 43 normal subjects were enrolled in the study. Carotid intima-media thickness (IMT) and plaques were detected in both groups. Blood samples were collected to measure the concentration of high sensitive C-reactive protein (hs-CRP) , fibrinogen (Fbg) , total cholesterol (TC) , triglyceride (TG) , high density lipoprotein cholesterol (HDL-C) , low density lipoprotein cholesterol (LDL-C) , while smoking index was recorded. Multiple regression analysis was performed to evaluate the correlative factors of IMT among COPD patients. According to whether luminal stenosis appeared, the COPD patients were allocated into group A ( without luminal stenosis) and group B ( with luminal stenosis) . Age, gender, hs-CRP, Fbg, TC, TG, HDL-C, LDL-C, and smoking index of the two groups were compared respectively.
Results  Hs-CRP, Fbg, thickness of IMT, plaques detection rate, and smoking index in the COPD group were significantly higher than those in the control group ( P lt;0.05) . TC, HDL-C, LDL-C in the COPD group were significantly lower than those in the control group ( P lt;0. 05) .Multiple regression analysis of IMT correlative factors among COPD patients showed that age, hs-CRP, Fbg, TC, TG, LDL-C, HDL-C, and smoking index were in linear relationship with IMT thickening. Age, hs-CRP, TC, and smoking index were positively correlated with IMT ( P lt;0.05) . Hs-CRP and smoking index in the group A were lower than those in the group B ( P lt;0. 05) .While TC, TG, LDL-C, and HDL-C in the group A were higher than those in the group B ( P lt;0.05) .
Conclusions  Age, smoking index, hs-CRP, and TC are risk factors for thickening of carotid artery IMT in COPD patients. Furthermore, smoking index, hs-CRP, TC, TG, LDL-C, and HDL-C are related to the severity of IMT thickening. The ultrasound detection of carotid artery IMT can be a valuble tool to screen atherosclerosis in patients with COPD.

Citation： GUO Lu,XIE Zhengliang,LIU Yuejian,LI Chunmei,LI Weimin. Study on the Correlation Between COPD and Atherosclerosis. Chinese Journal of Respiratory and Critical Care Medicine, 2011, 10(4): 376-379. doi: Copy