Objective  To investigate the correlation between serum level of visfatin and obesity in patients with obstructive sleep apnea hypopnea syndrome ( OSAHS) .
Methods  Forty-seven patients with OSAHS and 20 healthy controls were recruited in this study. Polysomnography was performed in all subjects to detect apnea-hypopnea index ( AHI) . The serumlevels of cisfatin, C-reactive protein ( CRP) , TNF-α, and IL-6 were measured by enzyme linked immunosorbent assay. The body mass inex ( BMI) was calculated.The level of cisfatin was compared between the OSAHS patients with different severity and the controls, and its relationship with the levels of AHI, BMI, CRP, TNF-α, and IL-6 was analyzed.
Results  The serumlevel of visfatin in the OSAHS patients was higher significantly than that in the controls ( P  lt;0. 01) and increased by the severity of OSAHS. There were positive correlations between the serum level of visfatin and AHI,BMI, CRP, TNF-α, IL-6 in the OSAHS patients ( P  lt;0. 05) .
Conclusion  The expression of visfatin may play an important role in the pathogenesis of OSAHS.

Citation： LI Jihong,WU Xiuming.. The Correlation Between Serum Visfatin and Inflammatory Reaction in Patients with Obstructive Sleep Apnea Hypopnea Syndrome. Chinese Journal of Respiratory and Critical Care Medicine, 2011, 10(5): 454-456. doi: Copy