ZHANG Tingting , GAO Baoan , CHEN Shixiong
  • Department of Respiratory Medicine, First College of Clinical Medical Science of China Three Gorges University &;
  • Yichang Central People’s Hospital. Yichang, Hubei, 443003, China;
Ventilator-associated pneumonia; Soluble triggering receptor expressed on myeloid cells-1; Mechanical ventilation; Endotracheal aspirate
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Objective  To evaluate the diagnostic value of soluble triggering receptor expressed on myeloid cells-1 ( sTREM-1 ) in endotracheal aspirate and plasma of patients with ventilator-associated pneumonia ( VAP) .
Methods  The consentration of sTREM-1 in plasma and endotracheal aspirate, and serum high-sensitivity C-reactive protein ( hs-CRP) were measured by enzyme-linked immunosorbent assay ( ELISA) in 68 patients with VAP ( VAP group) , 50 patients underwent ventilation without VAP ( non-VAP group) , and 50 healthy individuals ( control group) . The sensitivity and specificity of each parameter were calculated.
Results  In the patients with VAP, sTREM-1 in plasma and endotracheal aspirate before treatment were significantly higher than that in the non-VAP group [ ( 143.62 ±46.82) pg/mL vs. ( 68.56 ±16.24) pg/mL, ( 352.86 ±92.57) pg/mL vs. ( 126.21 ±42.28) pg/mL, P lt;0.05] ; sTREM-1 in plasma and endotracheal aspirate on the 3rd and the 7th day during treatment were significantly decreased ( P lt;0. 05) . By ROC analysis, the cut-off value of sTREM-1 in endotracheal aspirate were 193.64 pg/mL, with sensitivity and specificity of 93.84% and 89.51% respectively. The areas under ROC curve of sTREM-1 in endotracheal aspirate were 0.912. Clinical diagnostic value of sTREM-1 in endotracheal aspirate was better than plasma sTREM-1 and serum hs-CRP ( areas under ROC curve were 0. 768 and 0. 704 respectively) .
Conclusions  sTREM-1 may be helpful for evaluating the therapeutic effect in patients with VAP. The diagnostic value of sTREM-1 in endotracheal aspirate may be superior to plasma sTREM-1 and serum hs-CRP.

Citation： ZHANG Tingting,GAO Baoan,CHEN Shixiong. Clinical DiagnosticValue of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Ventilator- Associated Pneumonia. Chinese Journal of Respiratory and Critical Care Medicine, 2012, 11(1): 37-40. doi: Copy