CHEN Changzhi , ZHU Guichao , SHAO Youhe , WU Wenbin , QIN Jiameng
  • Department of Respiratory Medicine, Guigang City People’s Hospital, The Eighth Affiliated Hospital of Guangxi Medical University. Guigang, Guangxi, 537100, China Corresponding Author: CHEN Chang-zhi, E-mail: ggyyccz@ 163. com;
Chronic obstructive pulmonary disease; Thyroid hormone; Heart failure; Respiratory failure
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Objective  To investigate the therapeutic effects of thyroid hormone replacement on critically ill COPD patients with low serum thyroid hormone.
Methods  Sixty-seven critically ill patients with acute exacerbation of COPD ( AECOPD) , and complicated with respiratory and/ or heart failure and low serum thyroid hormone, admitted from July 2008 to June 2011, were recruited for the study. They were randomly divided into an intervention group ( n = 34) and a control group ( n = 33) . The control group received conventional treatment and the intervention group received conventional treatment plus additional thyroid hormone replacement therapy.
Results  Compared with the control group, the overall efficacy of the intervention group was not significantly different ( 88. 2% vs. 81. 8% , P  gt; 0. 05) , while average effective time was significantly shorter [ ( 9. 6 ±2. 5) d vs. ( 12. 3 ±2. 8) d, P  lt; 0. 05] . The post-treatment serum FT3 , FT4 , TT4 , and h-TSH levels were significantly higher in the intervention group than those in the control group, and significantly higher than baseline ( P  lt;0. 05) .
Conclusions  For AECOPD patients complicated with respiratory and/or heart failure and low serum thyroid hormone, thyroid hormone supplement at low dosage will help to improve serumthyroid hormone level, and promote early recovery.

Citation： CHEN Changzhi,ZHU Guichao,SHAO Youhe,WU Wenbin,QIN Jiameng. Effects of Thyroid Hormone Replacement Therapy on Critically Ill COPD Patients with Decreased Serum Thyroid Hormone. Chinese Journal of Respiratory and Critical Care Medicine, 2012, 11(1): 57-60. doi: Copy