Construction of an Anticoagulation Therapy Database of Chinese Patients after Heart Valve Replacement_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

Department of Cardiovascular Surgery，West China Hospital，Sichuan　University，Chengdu 610041，P. R.China;

Corresponding author：

Keywords：

Registered database; 　Heart valve replacement; 　Anticoagulation therapy

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Abstract： Objective To construct an Anticoagulation Therapy Database of Chinese Patients after Heart Valve　 Replacement in accordance with blood coagulation characteristics of Chinese patients， fill the gap of Chinese clinical research in valvular heart diseases， and provide a scientific and objective basic data and information exchange platform. Methods　 A national multicentre，prospective and cohort clinical research method was applied to establish an anticoagulation therapy database of Chinese patients after heart valve replacement， using the Internet as a platform. A case report form （CRF）， which was in line with the actual situation of Chinese anticoagulation patients after heart valve surgery， was formulated through the discussion of experts from 36 cardiovascular surgery centers in China in the starting meeting of National Science　 amp; Technology Support Program during the Twelfth Five-year Plan Period.We planned to prospectively include patients receiving warfarin anticoagulation therapy and formal anticoagulation monitoring after heart valve replacement from January 1, 2011 to December 31, 2014. Database was constructed using warehousing technology， which allowed not only data monitoring， query and statistics， but also regular　 data backup and system updates. Results A network database entitled Anticoagulant Therapy Database of Chinese Patients　 after Heart Valve Replacement was constructed and linked with the homepage of Chinese Journal of Clinical Thoracic and Cardiovascular Surgery （http：//www. zgxxwkzz. com）， which constituted a national Internet information platform. From 1 January 2011 to 1 December 2012， 8 452 anticoagulation patients after heart valve replacement from 34 level-3A hospitals in China had been registered in the database. Further follow-up of these patients was being carried out in respective hospitals. Conclusion A large multi-center and open database and network information platform has been constructed. The database variables are in line with clinical characteristics of Chinese anticoagulation patients after heart valve replacement， which provide scientific and objective basic data and support for future clinical research and systemic analysis.

Citation： FU Bo,DONG Li,SHI Yingkang. Construction of an Anticoagulation Therapy Database of Chinese Patients after Heart Valve Replacement. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2013, 20(1): 3-9. doi: Copy

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1. 　董力，石应康. 心脏机械瓣膜置换术后抗凝治疗. 中国胸心血管外科临床杂志， 2004， 11 （1）：63-67.
2. 　常颖，王一茹. 浅析军队医院信息系统数据仓库的构建. 中国中医药现代远程教育， 2011， 09 （9）：86-87.
3. 　Akins CW， Miller DC， Turina MI， et al. Guidelines for reporting mortality and morbidity after cardiac valve interventions. J Thorac Cardiovasc Surg， 2008， 135 （4）：732-738.
4. 　Kim YD， Cha MJ， Kim J， et al. Increases in cerebral atherosclerosis according to CHADS2 scores in patients with stroke with nonvalvular atrial fibrillation. Stroke， 2011， 42 （4）：930-934.
5. 　Grunkemeier GL， Furnary AP. Data variability and validity：the elephant in the room. J Thorac Cardiovasc Surg， 2010， 140 （2）：273-275.
6. 　Jamieson WR， Edwards FH， Schwartz M， et al. Risk stratification for cardiac valve replacement. National Cardiac Surgery Database. Database Committee of the Society of Thoracic Surgeons. Ann Thorac Surg， 1999， 67 （4）：943-951.
7. 　陈进，石应康，董力. 疾病预后因素研究设计在心脏瓣膜置换术后抗凝治疗临床研究中的应用. 中国胸心血管外科临床杂志， 2011， 18 （4）：286-288.
8. 　Gogbashian A， Sedrakyan A， Treasure T. EuroSCORE：a systematic review of international performance. Eur J Cardiothorac Surg， 2004， 25 （5）：695-700.
9. 　Edwards FH， Grover FL， Shroyer AL， et al. The Society of Thoracic　 Surgeons National Cardiac Surgery database：current risk assessment. Ann Thorac Surg， 1997， 63 （3）：903-908.
10. 　Nashef S， Roques F， Michel P， et al. European System for Cardiac Operative Risk Evaluation（EuroSCORE）. Eur J Cardiothorac Surg， 1999， 16 （1）：9-13.
11. 　Li Y， Zheng Z， Hu S， et al. The Chinese coronary artery bypass grafting registry study：analysis of the National multicentre database of 9248 patients. Heart， 2009， 95 （14）：1140-1144.
12. 　Zheng Z， Li Y， Zhang S， et al. The Chinese coronary artery bypass grafting registry study：how well does the EuroSCORE predict operative risk for Chinese population ? Eur J Cardiothorac Surg， 2009， 35（1）：54-58.
13. 　Whitlock RP， Sun JC， Fremes SE， et al. Antithrombotic and thrombolytic therapy for valvular disease：Antithrombotic Therapy and Prevention of Thrombosis， 9th ed：American College of Chest　 Physicians Evidence-Based Clinical Practice Guidelines. Chest， 2012， 141（2 Suppl）：e576S-e600S.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Construction of an Anticoagulation Therapy Database of Chinese Patients after Heart Valve Replacement

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