Research Progress of Myocardial Tissue Engineering Extracellular Matrix_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

LI Xianshuai , MU Junsheng.

Department of Cardiac Surgery， Beijing An Zhen Hospital， Capital University of Medical Science， Beijing 100029， P. R. China;

Corresponding author：

Keywords：

Myocardial tissue engineering; 　Extracellular matrix; 　Biological scaffold material; 　Synthetic scaffold material; 　Composite scaffold material

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

The establishing of myocardial tissue engineering techniques not only solve a series of issues that generate in cell and tissue transplantation after myocardial infarction, but also create a platform for selecting better materials and transplantation techniques. However, both experimental animal studies and recent clinical trials indicate that current transplantation techniques still have many defects, mainly including lack of suitable seed cells, low survival rate and low differentiation rate after transplantation. In this context, extracellular matrix （ECM）, as myocardial tissue engineering scaffold materials, has gained increasing attention and become a frontier and focus of medical research in recent years. ECM is no longer merely regarded as a scaffold or a tissue, but plays an important role in providing essential signals to influence major intracellular pathways such as cell proliferation, differentiation and metabolism. The involved models of ECM can be classified into following types：natural biological scaffold materials, synthetic polymer scaffold materials and composite scaffold materials with more balanced physical and biological properties. This review mainly introduces research progress of ECM in myocardial tissue engineering and ECM materials.

Citation： LI Xianshuai,MU Junsheng.. Research Progress of Myocardial Tissue Engineering Extracellular Matrix. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2012, 19(5): 555-558. doi: Copy

1.	Schussler O， Chachques JC， Mesana TG， et al. 3-dimensional structures to enhance cell therapy and engineer contractile tissue. Asian Cardiovasc Thorac Ann， 2010， 18 （2）：188-198.
2.	Barsotti MC， Felice F， Balbarini A， et al. Fibrin as a scaffold for cardiac tissue engineering. Biotechnol Appl Biochem， 2011， 58 （5）：301-310.
3.	Ahmed TE， Dare EV， Hincke M. Fibrin：a versatile scaffold for tissue engineering applications. Tissue Eng Part B Rev， 2008， 14 （2）：199-215.
4.	Kofidis T， Lenz A， Boublik J， et al. Bioartificial grafts for transmural myocardial restoration：a new cardiovascular tissue culture concept. Eur J Cardiothorac Surg， 2003， 24 （6）：906-911.
5.	Li RK， Jia ZQ， Weisel RD， et al. Survival and function of bioengineered cardiac grafts. Circulation， 1999， 100 （19 Suppl）：Ⅱ63-Ⅱ 69.
6.	Zimmermann WH， Schneiderbanger K， Schubert P， et al. Tissue engineering of a differentiated cardiac muscle construct. Circ Res， 2002， 90 （2）：223-230.
7.	Stern R， Asari AA， Sugahara KN. Hyaluronan fragments：an information-rich system. Eur J Cell Biol， 2006， 85 （8）：699-715.
8.	Zhu H， Mitsuhashi N， Klein A， et al. The role of the hyaluronan　receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Stem Cells， 2006， 24 （4）：928-935.
9.	Leor J， Aboulafia-Etzion S， Dar A， et al. Bioengineered cardiac grafts：A new approach to repair the infarcted myocardium? Circulation， 2000， 102 （19 Suppl 3）：Ⅲ56-Ⅲ61.
10.	Muller FA， Lenka M， Ingo H， et al. Cellulose-based scaffold materials for cartilage tissue engineering. Biomaterials， 2006， 27 （21）：3955-3963.
11.	Emilia E， Bien H， Yin LH， et al. Functional cardiac cell constructs on cellulose-based scaffolding. Biomaterials， 2004， 25 （26）：5753-5762.
12.	Matis M， Viljanto J， Hurme T， et al. Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat. Biomaterials， 1999， 20 （21）：1989-1995.
13.	Vanore M， Chahory S， Payen G， et al. Surgical repair of deep melting ulcers with porcine small intestinal submucosa （SIS） graft in dogs and Cats. Vet Ophthalmol， 2007， 10 （2）：93-99.
14.	Robinson KA， Li J， Mathison M， et al. Extracellular matrix scaffold for cardiac repair. Circulation， 2005， 112 （9 Suppl）：I135- I143.
15.	Singelyn JM， Dequach JA， Seif-Naraghi SB， et al. Naturally　derived myocardial matrix as an injectable scaffold for cardiac tissue engineering. Biomaterials， 2009， 30 （29）：5409-5416.
16.	Ott HC， Matthiesen TS， Goh SK， et al. Perfusion-decellularized matrix：using Nature’s platform to engineer a bioartificial heart. Nat Med， 2008， 14 （2）：213-221.
17.	Haraguchi Y， Shimizu T， Yamato M， et al. Regenerative therapies using cell sheet-based tissue　engineering for cardiac disease. Cardiol Res Pract， 2011， 845170.
18.	Matsuda N， Tatsuya S， Masayuki Y， et al. Tissue engineering based on cell sheet technology. Advanced Materials， 2007， 19 （20）：3089-3099.
19.	Masuda S， Shimizu T， Yamato M， et al. Cell sheet engineering for heart tissue repair. Adv Drug Deliv Rev， 2008，60 （2）：277-285.
20.	Sekine H， Shimizu T， Kosaka S， et al. Cardiomyocyte bridging between hearts and bioengineered myocardial tissues with mesenchymal transition of mesothelial cells. J Heart Lung Transplant， 2006， 25 （3）：324-332.
21.	Miyagawa S， Saito A， Sakaguchi T， et al. Impaired myocardium regeneration with skeletal cell sheets—— a preclinical trial for tissue-engineered regeneration therapy. Transplantation， 2010， 90 （4）：364-372.
22.	Hida N， Nishiyama N， Miyoshi S， et al. Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells. Stem Cells， 2008， 26 （7）：1695-1704.
23.	Radisic M， Park H， Martens TP， et al. Pre-treatment of synthetic elastomeric scaffolds by cardiac fibroblasts improves engineered heart tissue. J Biomed Mater Res A， 2008， 86 （3）：713-724.
24.	Singh D， Nayak V， Kumar A. Proliferation of myoblast skeletal cells on three-dimensional　supermacroporous cryogels. Int J Biol Sci， 2010， 6 （4）：371-381.
25.	Jin J， Jeong SI， Shin YM， et al. Transplantation of mesenchymal stem cells within a poly （lactide-co-epsilon-caprolactone） scaffold improves cardiac function in a rat myocardial infarction model. Eur J Heart Fail， 2009，11 （2）：147-153.
26.	Lee EJ， Vunjak-Novakovic G， Wang Y， et al. A biocompatible endothelial cell delivery system for in vitro tissue engineering. Cell Transplant， 2009， 18 （7）：731-743.
27.	Heydarkhan-Hagvall S， Choi CH， Dunn J， et al. Influence of systematically varied nano-scale topography on cell morphology and adhesion. Cell Commun Adhes， 2007， 14 （5）：181-194.
28.	Akhyari P， Kamiya H， Haverich A， et al. Myocardial tissue engineering：the extracellular matrix.Eur J Cardiothorac Surg， 2008，34 （2）：229-241.
29.	Boublik J， Park H， Radisic M， et al. Mechanical properties and　remodeling of hybrid cardiac constructs made from heart cells， fibrin， and biodegradable， elastomeric knitted fabric. Tissue Eng， 2005， 11 （7-8）：1122-1132.
30.	Ashton RS， Akhilesh B， Supriya P， et al. Scaffolds based on degradable alginate hydrogels and poly （lactide-co-glycolide） microspheres for stem cell culture. Biomaterials， 2007， 28 （36）：5518-5525.

1. 　Schussler O， Chachques JC， Mesana TG， et al. 3-dimensional structures to enhance cell therapy and engineer contractile tissue. Asian Cardiovasc Thorac Ann， 2010， 18 （2）：188-198.
2. 　Barsotti MC， Felice F， Balbarini A， et al. Fibrin as a scaffold for cardiac tissue engineering. Biotechnol Appl Biochem， 2011， 58 （5）：301-310.
3. 　Ahmed TE， Dare EV， Hincke M. Fibrin：a versatile scaffold for tissue engineering applications. Tissue Eng Part B Rev， 2008， 14 （2）：199-215.
4. 　Kofidis T， Lenz A， Boublik J， et al. Bioartificial grafts for transmural myocardial restoration：a new cardiovascular tissue culture concept. Eur J Cardiothorac Surg， 2003， 24 （6）：906-911.
5. 　Li RK， Jia ZQ， Weisel RD， et al. Survival and function of bioengineered cardiac grafts. Circulation， 1999， 100 （19 Suppl）：Ⅱ63-Ⅱ 69.
6. 　Zimmermann WH， Schneiderbanger K， Schubert P， et al. Tissue engineering of a differentiated cardiac muscle construct. Circ Res， 2002， 90 （2）：223-230.
7. 　Stern R， Asari AA， Sugahara KN. Hyaluronan fragments：an information-rich system. Eur J Cell Biol， 2006， 85 （8）：699-715.
8. 　Zhu H， Mitsuhashi N， Klein A， et al. The role of the hyaluronan　receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Stem Cells， 2006， 24 （4）：928-935.
9. 　Leor J， Aboulafia-Etzion S， Dar A， et al. Bioengineered cardiac grafts：A new approach to repair the infarcted myocardium? Circulation， 2000， 102 （19 Suppl 3）：Ⅲ56-Ⅲ61.
10. 　Muller FA， Lenka M， Ingo H， et al. Cellulose-based scaffold materials for cartilage tissue engineering. Biomaterials， 2006， 27 （21）：3955-3963.
11. 　Emilia E， Bien H， Yin LH， et al. Functional cardiac cell constructs on cellulose-based scaffolding. Biomaterials， 2004， 25 （26）：5753-5762.
12. 　Matis M， Viljanto J， Hurme T， et al. Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat. Biomaterials， 1999， 20 （21）：1989-1995.
13. 　Vanore M， Chahory S， Payen G， et al. Surgical repair of deep melting ulcers with porcine small intestinal submucosa （SIS） graft in dogs and Cats. Vet Ophthalmol， 2007， 10 （2）：93-99.
14. 　Robinson KA， Li J， Mathison M， et al. Extracellular matrix scaffold for cardiac repair. Circulation， 2005， 112 （9 Suppl）：I135- I143.
15. 　Singelyn JM， Dequach JA， Seif-Naraghi SB， et al. Naturally　derived myocardial matrix as an injectable scaffold for cardiac tissue engineering. Biomaterials， 2009， 30 （29）：5409-5416.
16. 　Ott HC， Matthiesen TS， Goh SK， et al. Perfusion-decellularized matrix：using Nature’s platform to engineer a bioartificial heart. Nat Med， 2008， 14 （2）：213-221.
17. 　Haraguchi Y， Shimizu T， Yamato M， et al. Regenerative therapies using cell sheet-based tissue　engineering for cardiac disease. Cardiol Res Pract， 2011， 845170.
18. 　Matsuda N， Tatsuya S， Masayuki Y， et al. Tissue engineering based on cell sheet technology. Advanced Materials， 2007， 19 （20）：3089-3099.
19. 　Masuda S， Shimizu T， Yamato M， et al. Cell sheet engineering for heart tissue repair. Adv Drug Deliv Rev， 2008，60 （2）：277-285.
20. 　Sekine H， Shimizu T， Kosaka S， et al. Cardiomyocyte bridging between hearts and bioengineered myocardial tissues with mesenchymal transition of mesothelial cells. J Heart Lung Transplant， 2006， 25 （3）：324-332.
21. 　Miyagawa S， Saito A， Sakaguchi T， et al. Impaired myocardium regeneration with skeletal cell sheets—— a preclinical trial for tissue-engineered regeneration therapy. Transplantation， 2010， 90 （4）：364-372.
22. 　Hida N， Nishiyama N， Miyoshi S， et al. Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells. Stem Cells， 2008， 26 （7）：1695-1704.
23. 　Radisic M， Park H， Martens TP， et al. Pre-treatment of synthetic elastomeric scaffolds by cardiac fibroblasts improves engineered heart tissue. J Biomed Mater Res A， 2008， 86 （3）：713-724.
24. 　Singh D， Nayak V， Kumar A. Proliferation of myoblast skeletal cells on three-dimensional　supermacroporous cryogels. Int J Biol Sci， 2010， 6 （4）：371-381.
25. 　Jin J， Jeong SI， Shin YM， et al. Transplantation of mesenchymal stem cells within a poly （lactide-co-epsilon-caprolactone） scaffold improves cardiac function in a rat myocardial infarction model. Eur J Heart Fail， 2009，11 （2）：147-153.
26. 　Lee EJ， Vunjak-Novakovic G， Wang Y， et al. A biocompatible endothelial cell delivery system for in vitro tissue engineering. Cell Transplant， 2009， 18 （7）：731-743.
27. 　Heydarkhan-Hagvall S， Choi CH， Dunn J， et al. Influence of systematically varied nano-scale topography on cell morphology and adhesion. Cell Commun Adhes， 2007， 14 （5）：181-194.
28. 　Akhyari P， Kamiya H， Haverich A， et al. Myocardial tissue engineering：the extracellular matrix.Eur J Cardiothorac Surg， 2008，34 （2）：229-241.
29. 　Boublik J， Park H， Radisic M， et al. Mechanical properties and　remodeling of hybrid cardiac constructs made from heart cells， fibrin， and biodegradable， elastomeric knitted fabric. Tissue Eng， 2005， 11 （7-8）：1122-1132.
30. 　Ashton RS， Akhilesh B， Supriya P， et al. Scaffolds based on degradable alginate hydrogels and poly （lactide-co-glycolide） microspheres for stem cell culture. Biomaterials， 2007， 28 （36）：5518-5525.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Research Progress of Myocardial Tissue Engineering Extracellular Matrix

Abstract Full text Figures/Tables Video References Cited by

Format

Content