LI Weiguo , GU Tianxiang , SHEN Lianyu
  • 1.Department of Cardiovascular Surgery, Central Hospital of Jinzhou, Jinzhou 121000, Liaoning, P.R. China;;
  • 2. Department of Cardiac Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, P.R. China;
Liposomal prostaglandin E1; Inflammatory reaction; Cardiopulmonary bypass; Coronary artery bypass grafting
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Abstract: Objective To investigate the effect of liposomal pro
staglandin E1 (LipoPGE1) on inflammatory reaction during cardiopulmonary b
ypass (CPB) coronary artery bypass grafting (CABG). Methods Be
tween July 2006 and December 2008, a total of 32 patients undergoing CABG were r
andomly divided into two groups of 16 pa
tients each using a random digits table. The experimental group had 9 male and 7
female patients with a mean age of 54.4±18.1 years; each patient received 15.0
ng/(kg·min) of LipoPGE1 by venous pump through the central vein throughout
theCPB procedure. The control group had 9 male and 7 female patients with a mean a
ge of 54.8±20.4 years, who were treated identically to the experimental group e
xcept did not receive LipoPGE1. Arterial blood samples were taken before CPB
and at the 1st, 2nd, 6th, and 24th hour after open aorta ascendens. The levels of
interleukin6(IL6), tumor necrosis factorα (TNFα), and soluble interce
llular adhesion molecule1 (sICAM1) were tested and compared. Results
In both groups, levels of IL6, TNFα, and sICAM1 were all gradually increased after the as
cending aorta was opened, and they reached their highest levels at the 6th hour
after open aorta ascendens. In the experimental group, at every time point after
the ascending aorta was open, levels of IL6 (24th hour after open aorta ascen
dens: 16.1±2.2 μg/L vs. 19.2±4.5 μg/L,P lt;0.05), TNFα (24th hour after
open aorta ascendens: 1.8±04 μg/L vs. 2.2±0.5 μg/L,P lt;0.05), and sICAM
1 (24th hour after open aorta ascendens: 233.6±36.6 μg/L vs. 294.2±55.7 μg
/L,P lt;0.05) were significantly lower than those of the control group. 〖WTHZ
〗Conclusion LipoPGE1 effectively reduces the aggregation of polymo
rphonuclear neutrophilic leukocytes, inhibits activation of vascular endothelial
cells, and decreases systemic inflammatorome during CPB.

Citation： LI Weiguo,GU Tianxiang,SHEN Lianyu,et al .. Effect of Liposomal Prostaglandin E1 on Inflammatory Reaction During Cardiopulmonary Bypass Coronary Artery Bypass Grafting. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2011, 18(6): 510-. doi: Copy