ZHANG Yan , HU Shengshou , ZHOU Jianye , et al .
  • 1Research Center for Cardiovascular Regenerative Medicine of the Ministry of Health, Fu Wai Cardiovascular Hospital， Chinese Academy of Medical Sciences &;
  • Peking Union Medical College;;
  • 2.Department of Cardiac Surgery, Fu Wai Cardiovascular Hospital， Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing 100037，P．R．China;
Axial blood pump; Hemolysis; In vivo testing; Animal testing; Normalized index of hemolysis
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Objective To provide a ventricular assist device for patients with heart failure, Fu Wai （FW） axial blood pump was developed for partly or totally to assist the left ventricular function. Vitro hemolysis and animals tests were also employed to test the hydromechanics and hemocompatibility of the FW left ventricular assist devices developed in Fu Wai hospital. Methods Using vitro test loop, FW axial blood pump has been used to evaluate the performance of hemolysis， the pump has also been tested for hemolysis characteristic through five sheep experiments. Results At 8 400 r/min, the pump generates 5 L/min flow against 100 mm Hg, the normalized index of hemolysis (NIH) was0.17±0.06 mg/L. The plasma free hemoglobin of in vivo tests was around 30 mg/dl. Conclusion The results obtained in vitro and in vivo testing indicate an acceptable design for the blood pump, further in vivo tests will be performed before clinical use.

Citation： ZHANG Yan ,HU Shengshou,ZHOU Jianye,et al .. Experimental Study of Hemolysis in Vitro and Animal Testing for Fu Wai Axial Blood Pump. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2009, 16(2): 114-117. doi: Copy