• 1. Department of Thoracic and Cardiovascular Surgery, No. 6 People＇s Hospital, Shanghai Jiaotong University, Shanghai 200233,P. R. China. ;;
  • 2. Department of Public Health and Molecular Biology Research, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200233, P. R.China;
Lung adenocarcinoma; Biomarker; Surface-enhanced laser desorption ionization time of flight mass spectrometry; Proteomic
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Objective To select relatively specific biomarkers in serum from lung adenocarcinoma patients using surface-enhanced laser desorption ionization time of flight mass spectrometry （SELDI-TOF-MS） Protein Chip technology, and study the follow-up results of postoperative serum proteomic patterns. Methods Serum samples from 71 lung adenocarcinoma patients. 71 healthy volunteers with matched gender, age and history of smoking were analyzed by using weak cation exchange 2（WCX2） Protein Chip to select potentially biomarkers. Seventy-one patients were followed-up till 9 months after surgery. Compare the serum proteomic patterns 3,6 and 9 months after surgery. Results Five highly expressed potential biomarkers were identified with the relative molecular weights of 4 047.79, 4 203. 99, 4 959. 81, 5 329. 30 and 7 760. 12 Da. The postoperative serum proteomic patterns changed among individuals, and correlated with patients＇ clinical stage. Conclusions SELDI-TOF-MS Protein Chip technology is a quick, easy, convenient, and high-throughout analyzing method capable of selecting relatively specific, potential biomarkers from the serum of lung adenocarcinoma patients and may have attractive clinical value.

Citation： LUO Xiao yang ,CHEN Haiquan,ZHOU Jianhua,et al .. Follow-up Analysis of Postoperative Serum Proteomic Patterns in Patients of Lung Adenocarcinoma. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2006, 13(2): 69-72. doi: Copy