RESEARCH PROGRESS OF ARTICULAR CARTILAGE SCAFFOLD FOR TISSUE ENGINEERING_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

LIU Qingyu , WANG Fuyou , YANG Liu.

Center for Joint Surgery, Southwest Hospital, the Third Military Medical University, Chongqing, 400038, P.R.China. Corresponding author: YANG Liu, E-mail: jointsurgery@163.com;

Corresponding author：

Keywords：

Cartilage tissue engineering; Scaffold material; Biocompatibility

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Objective To review the research progress of articular cartilage scaffold materials and look into the future development prospects. Methods Recent literature about articular cartilage scaffold for tissue engineering was reviewed, and the results from experiments and clinical application about natural and synthetic scaffold materials were analyzed. Results The design of articular cartilage scaffold for tissue engineering is vital to articular cartilage defects repair. The ideal scaffold can promote the progress of the cartilage repair, but the scaffold materials still have their limitations. Conclusion It is necessary to pay more attention to the research of the articular cartilage scaffold, which is significant to the repair of cartilage defects in the future.

Citation： LIU Qingyu,WANG Fuyou,YANG Liu.. RESEARCH PROGRESS OF ARTICULAR CARTILAGE SCAFFOLD FOR TISSUE ENGINEERING. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(10): 1247-1250. doi: Copy

1.	Poole CA. Articular cartilage chondrons: form, function and failure. J Anat, 1997, 191(Pt 1): 1-13.
2.	Mcnickle AG, Provencher MT, Cole BJ. Overview of existing cartilage repair technology. Sports Med Arthrosc, 2008, 16(4): 196-201.
3.	Thiede RM, Lu Y, Markel MD. A review of the treatment methods for cartilage defects. Vet Comp Orthop Traumatol, 2012, 25(4): 263-272.
4.	Hurtig M, Pearce S, Warren S, et al. Arthroscopic mosaic arthroplasty in the equine third carpal bone. Vet Surg, 2001, 30(3): 228-239.
5.	Solheim E, Hegna J, Oyen J, et al. Osteochondral autografting (mosaicplasty) in articular cartilage defects in the knee: results at 5 to 9 years. Knee, 2010, 17(1): 84-87.
6.	Bugbee WD. Fresh osteochondral allografts. J Knee Surg, 2002, 15(3): 191-195.
7.	Stevenson S, Dannucci GA, Sharkey NA, et al. The fate of articular cartilage after transplantation of fresh and cryopreserved tissue-antigen-matched and mismatched osteochondral allografts in dogs. J Bone Joint Surg (Am), 1989, 71(9): 1297-1307.
8.	Danisovic L, Varga I, Zamborsky R, et al. The tissue engineering of articular cartilage: cells, scaffolds and stimulating factors. Exp Biol Med (Maywood), 2012, 237(1): 10-17.
9.	Chung C, Burdick JA. Engineering cartilage tissue. Adv Drug Deliv Rev, 2008, 60(2): 243-262.
10.	Bryant SJ, Anseth KS. Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage. J Biomed Mater Res A, 2003, 64(1): 70-79.
11.	Yang Q, Peng J, Guo Q, et al. A cartilage ECM-derived 3-D porous acellular matrix scaffold for in vivo cartilage tissue engineering with PKH26-labeled chondrogenic bone marrow-derived mesenchymal stem cells. Biomaterials, 2008, 29(15): 2378-2387.
12.	Wang Y, Bella E, Lee CS, et al. The synergistic effects of 3-D porous silk fibroin matrix scaffold properties and hydrodynamic environment in cartilage tissue regeneration. Biomaterials, 2010, 31(17): 4672-4681.
13.	Gong YY, Xue JX, Zhang WJ, et al. A sandwich model for engineering cartilage with acellular cartilage sheets and chondrocytes. Biomaterials, 2011, 32(9): 2265-2273.
14.	Crapo PM, Gilbert TW, Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials, 2011, 32(12): 3233-3243.
15.	Grande DA, Halberstadt C, Naughton G, et al. Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts. J Biomed Mater Res, 1997, 34(2): 211-220.
16.	李斯明, 杨小红, 方力, 等. 高纯度猪软骨Ⅱ型胶原修复兔膝关节软骨缺损的实验研究. 中华创伤骨科杂志, 2008, 10(9): 844-849.
17.	Wakitani S, Goto T, Pineda SJ, et al. Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg (Am), 1994, 76(4): 579-592.
18.	Chenite A, Chaput C, Wang D, et al. Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials, 2000, 21(21): 2155-2161.
19.	Montembault A, Tahiri K, Korwin-Zmijowska C, et al. A material decoy of biological media based on chitosan physical hydrogels: application to cartilage tissue engineering. Biochimie, 2006, 88(5): 551-564.
20.	Toh WS, Lee EH, Guo XM, et al. Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells. Biomaterials, 2010, 31(27): 6968-6980.
21.	Stok KS, Lisignoli G, Cristino S, et al. Mechano-functional assessment of human mesenchymal stem cells grown in three-dimensional hyaluronan-based scaffolds for cartilage tissue engineering. J Biomed Mater Res A, 2010, 93(1): 37-45.
22.	Wang W, Li B, Yang J, et al. The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs. Biomaterials, 2010, 31(34): 8964-8973.
23.	Hendrickson DA, Nixon AJ, Grande DA, et al. Chondrocyte-fibrin matrix transplants for resurfacing extensive articular cartilage defects. J Orthop Res, 1994, 12(4): 485-497.
24.	Dare EV, Griffith M, Poitras P, et al. Fibrin sealants from fresh or fresh/frozen plasma as scaffolds for in vitro articular cartilage regeneration. Tissue Eng Part A, 2009, 15(8): 2285-2297.
25.	Kawabe N, Yoshinao M. The repair of full-thickness articular cartilage defects. Immune responses to reparative tissue formed by allogeneic growth plate chondrocyte implants. Clin Orthop Relat Res, 1991, (268): 279-293.
26.	Kawakami M, Tomita N, Shimada Y, et al. Chondrocyte distribution and cartilage regeneration in silk fibroin sponge. Biomed Mater Eng, 2011, 21(1): 53-61.
27.	Wooley PH, Morren R, Andary J, et al. Inflammatory responses to orthopaedic biomaterials in the murine air pouch. Biomaterials, 2002, 23(2): 517-526.
28.	Wang CC, Yang KC, Lin KH, et al. Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold. Biomaterials, 2012, 33(1): 120-127.
29.	张军军, 任龙喜, 程爱国, 等. PLA-MSCs复合培养物植入修复兔关节软骨缺损的实验研究. 中国骨肿瘤骨病, 2005, 4(5): 293-296.
30.	Chu CR, Coutts RD, Yoshioka M, et al. Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): a tissue-engineering study. J Biomed Mater Res, 1995, 29(9): 1147-1154.
31.	陈莉, 赵保中, 杜锡光. 聚羟基乙酸及其共聚物的研究进展. 化工新型材料, 2002, 30(3): 11-15.
32.	孙安科, 陈文弦, 崔鹏程, 等. 以PGA为三维支架同种异体工程化软骨的构建. 解放军医学杂志, 2001, 26(10): 748-749.
33.	El Sayed K, Marzahn U, John T, et al. PGA-associated heterotopic chondrocyte cocultures: implications of nasoseptal and auricular chondrocytes in articular cartilage repair. J Tissue Eng Regen Med, 2011. [Epub ahead of print].
34.	张路, 李琼, 周广东, 等. 不同比例的PLA-PGA支架对软骨细胞复合的影响. 组织工程与重建外科, 2008, 4(6): 305-307.
35.	Cohen SB, Meirisch CM, Wilson HA, et al. The use of absorbable co-polymer pads with alginate and cells for articular cartilage repair in rabbits. Biomaterials, 2003, 24(15): 2653-2660.
36.	Zhao H, Ma L, Gao C, et al. A composite scaffold of PLGA microspheres/fibrin gel for cartilage tissue engineering: fabrication, physical properties, and cell responsiveness. J Biomed Mater Res B Appl Biomater, 2009, 88(1): 240-249.
37.	Tiğli RS, Gümüşderelioğlu M. Evaluation of alginate-chitosan semi IPNs as cartilage scaffolds. J Mater Sci Mater Med, 2009, 20(3): 699-709.
38.	Laurens E, Schneider E, Winalski CS, et al. A synthetic cartilage extracellular matrix model: hyaluronan and collagen hydrogel relaxivity, impact of macromolecular concentration on dGEMRIC. Skeletal Radiol, 2012, 41(2): 209-217.
39.	Bhardwaj N, Nguyen QT, Chen AC, et al. Potential of 3-D tissue constructs engineered from bovine chondrocytes/silk fibroin-chitosan for in vitro cartilage tissue engineering. Biomaterials, 2011, 32(25): 5773-5781.

1. Poole CA. Articular cartilage chondrons: form, function and failure. J Anat, 1997, 191(Pt 1): 1-13.
2. Mcnickle AG, Provencher MT, Cole BJ. Overview of existing cartilage repair technology. Sports Med Arthrosc, 2008, 16(4): 196-201.
3. Thiede RM, Lu Y, Markel MD. A review of the treatment methods for cartilage defects. Vet Comp Orthop Traumatol, 2012, 25(4): 263-272.
4. Hurtig M, Pearce S, Warren S, et al. Arthroscopic mosaic arthroplasty in the equine third carpal bone. Vet Surg, 2001, 30(3): 228-239.
5. Solheim E, Hegna J, Oyen J, et al. Osteochondral autografting (mosaicplasty) in articular cartilage defects in the knee: results at 5 to 9 years. Knee, 2010, 17(1): 84-87.
6. Bugbee WD. Fresh osteochondral allografts. J Knee Surg, 2002, 15(3): 191-195.
7. Stevenson S, Dannucci GA, Sharkey NA, et al. The fate of articular cartilage after transplantation of fresh and cryopreserved tissue-antigen-matched and mismatched osteochondral allografts in dogs. J Bone Joint Surg (Am), 1989, 71(9): 1297-1307.
8. Danisovic L, Varga I, Zamborsky R, et al. The tissue engineering of articular cartilage: cells, scaffolds and stimulating factors. Exp Biol Med (Maywood), 2012, 237(1): 10-17.
9. Chung C, Burdick JA. Engineering cartilage tissue. Adv Drug Deliv Rev, 2008, 60(2): 243-262.
10. Bryant SJ, Anseth KS. Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage. J Biomed Mater Res A, 2003, 64(1): 70-79.
11. Yang Q, Peng J, Guo Q, et al. A cartilage ECM-derived 3-D porous acellular matrix scaffold for in vivo cartilage tissue engineering with PKH26-labeled chondrogenic bone marrow-derived mesenchymal stem cells. Biomaterials, 2008, 29(15): 2378-2387.
12. Wang Y, Bella E, Lee CS, et al. The synergistic effects of 3-D porous silk fibroin matrix scaffold properties and hydrodynamic environment in cartilage tissue regeneration. Biomaterials, 2010, 31(17): 4672-4681.
13. Gong YY, Xue JX, Zhang WJ, et al. A sandwich model for engineering cartilage with acellular cartilage sheets and chondrocytes. Biomaterials, 2011, 32(9): 2265-2273.
14. Crapo PM, Gilbert TW, Badylak SF. An overview of tissue and whole organ decellularization processes. Biomaterials, 2011, 32(12): 3233-3243.
15. Grande DA, Halberstadt C, Naughton G, et al. Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts. J Biomed Mater Res, 1997, 34(2): 211-220.
16. 李斯明, 杨小红, 方力, 等. 高纯度猪软骨Ⅱ型胶原修复兔膝关节软骨缺损的实验研究. 中华创伤骨科杂志, 2008, 10(9): 844-849.
17. Wakitani S, Goto T, Pineda SJ, et al. Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg (Am), 1994, 76(4): 579-592.
18. Chenite A, Chaput C, Wang D, et al. Novel injectable neutral solutions of chitosan form biodegradable gels in situ. Biomaterials, 2000, 21(21): 2155-2161.
19. Montembault A, Tahiri K, Korwin-Zmijowska C, et al. A material decoy of biological media based on chitosan physical hydrogels: application to cartilage tissue engineering. Biochimie, 2006, 88(5): 551-564.
20. Toh WS, Lee EH, Guo XM, et al. Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells. Biomaterials, 2010, 31(27): 6968-6980.
21. Stok KS, Lisignoli G, Cristino S, et al. Mechano-functional assessment of human mesenchymal stem cells grown in three-dimensional hyaluronan-based scaffolds for cartilage tissue engineering. J Biomed Mater Res A, 2010, 93(1): 37-45.
22. Wang W, Li B, Yang J, et al. The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs. Biomaterials, 2010, 31(34): 8964-8973.
23. Hendrickson DA, Nixon AJ, Grande DA, et al. Chondrocyte-fibrin matrix transplants for resurfacing extensive articular cartilage defects. J Orthop Res, 1994, 12(4): 485-497.
24. Dare EV, Griffith M, Poitras P, et al. Fibrin sealants from fresh or fresh/frozen plasma as scaffolds for in vitro articular cartilage regeneration. Tissue Eng Part A, 2009, 15(8): 2285-2297.
25. Kawabe N, Yoshinao M. The repair of full-thickness articular cartilage defects. Immune responses to reparative tissue formed by allogeneic growth plate chondrocyte implants. Clin Orthop Relat Res, 1991, (268): 279-293.
26. Kawakami M, Tomita N, Shimada Y, et al. Chondrocyte distribution and cartilage regeneration in silk fibroin sponge. Biomed Mater Eng, 2011, 21(1): 53-61.
27. Wooley PH, Morren R, Andary J, et al. Inflammatory responses to orthopaedic biomaterials in the murine air pouch. Biomaterials, 2002, 23(2): 517-526.
28. Wang CC, Yang KC, Lin KH, et al. Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold. Biomaterials, 2012, 33(1): 120-127.
29. 张军军, 任龙喜, 程爱国, 等. PLA-MSCs复合培养物植入修复兔关节软骨缺损的实验研究. 中国骨肿瘤骨病, 2005, 4(5): 293-296.
30. Chu CR, Coutts RD, Yoshioka M, et al. Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): a tissue-engineering study. J Biomed Mater Res, 1995, 29(9): 1147-1154.
31. 陈莉, 赵保中, 杜锡光. 聚羟基乙酸及其共聚物的研究进展. 化工新型材料, 2002, 30(3): 11-15.
32. 孙安科, 陈文弦, 崔鹏程, 等. 以PGA为三维支架同种异体工程化软骨的构建. 解放军医学杂志, 2001, 26(10): 748-749.
33. El Sayed K, Marzahn U, John T, et al. PGA-associated heterotopic chondrocyte cocultures: implications of nasoseptal and auricular chondrocytes in articular cartilage repair. J Tissue Eng Regen Med, 2011. [Epub ahead of print].
34. 张路, 李琼, 周广东, 等. 不同比例的PLA-PGA支架对软骨细胞复合的影响. 组织工程与重建外科, 2008, 4(6): 305-307.
35. Cohen SB, Meirisch CM, Wilson HA, et al. The use of absorbable co-polymer pads with alginate and cells for articular cartilage repair in rabbits. Biomaterials, 2003, 24(15): 2653-2660.
36. Zhao H, Ma L, Gao C, et al. A composite scaffold of PLGA microspheres/fibrin gel for cartilage tissue engineering: fabrication, physical properties, and cell responsiveness. J Biomed Mater Res B Appl Biomater, 2009, 88(1): 240-249.
37. Tiğli RS, Gümüşderelioğlu M. Evaluation of alginate-chitosan semi IPNs as cartilage scaffolds. J Mater Sci Mater Med, 2009, 20(3): 699-709.
38. Laurens E, Schneider E, Winalski CS, et al. A synthetic cartilage extracellular matrix model: hyaluronan and collagen hydrogel relaxivity, impact of macromolecular concentration on dGEMRIC. Skeletal Radiol, 2012, 41(2): 209-217.
39. Bhardwaj N, Nguyen QT, Chen AC, et al. Potential of 3-D tissue constructs engineered from bovine chondrocytes/silk fibroin-chitosan for in vitro cartilage tissue engineering. Biomaterials, 2011, 32(25): 5773-5781.

Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH PROGRESS OF ARTICULAR CARTILAGE SCAFFOLD FOR TISSUE ENGINEERING

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