RESEARCH PROGRESS OF EXTRACELLULAR MATRIX MATERIAL FOR TISSUE ENGINEERING_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

YUAN Haichao , PU Chunxiao , WEI Qiang , HAN Ping.

Department of Urology, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China. Corresponding author: HAN Ping, E-mail: hanping@scu.edu.cn;

Corresponding author：

Keywords：

Tissue engineering; Scaffold material; Extracellular matrix

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Objective To review the current research status and clinical application progress of extracellular matrix (ECM) material in tissue engineering. Methods The literature about the latest progress in the preparation, biocompatibility, mechanical property, degradability, and clinical application of ECM material was extensively reviewed. Results The improvement of the ECM preparation method and thorough understanding of the immunological properties have laid the foundation for the repair and reconstruction of the tissue. Moreover, a series of animal studies also confirm that the feasibility and effectiveness of the ECM such as small intestinal submucosa, bladder ECM grift, and acellular dermis which have been applied to the repair and reconstruction of the urethra, bladder, arteries, and skin tissue. It shows a wide prospect of clinical application in the future. Conclusion ECM material is a good bio-derived scaffold, which is expected to become an important source of alternative materials for the repair and reconstruction of the tissue.

Citation： YUAN Haichao,PU Chunxiao,WEI Qiang,HAN Ping.. RESEARCH PROGRESS OF EXTRACELLULAR MATRIX MATERIAL FOR TISSUE ENGINEERING. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(10): 1251-1254. doi: Copy

1.	Huebsh N, Moony DJ. Inspiration and application in the evolution of biomaterials. Nature, 2009, 462(7272): 426-432.
2.	罗静聪, 杨志明, 李秀群, 等. 小肠黏膜下层细胞相容性的研究. 生物医学工程学杂志, 2004, 21(5): 800-804.
3.	韩平, 宋超, 魏强, 等. 组织工程膀胱细胞外基质生物相容性的实验研究. 四川大学学报: 医学版, 2007, 38(6): 1009-1012.
4.	孔清泉, 高博, 幸嵘, 等. 以小肠黏膜下层为支架体外构建组织工程软骨的实验研究. 生物医学工程学杂志, 2011, 28(3): 521-525.
5.	Zhu WD, Xu YM, Feng C, et al. Different bladder defects reconstructed with bladder acellular matrix grafts in a rabbit model. Urologe A, 2011, 50(11): 1420-1425.
6.	Gilbert TW, Sellaro TL, Badylak SF. Decellularization of tissues and organs. Biomaterials, 2006, 27(19): 3675-3683.
7.	罗静聪, 杨志明. 小肠黏膜下层的制备及其特性的研究进展. 中国修复重建外科杂志, 2003, 17(5): 425-428.
8.	Luo JC, Chen W, Chen XH, et al. A multi-step method for preparation of porcine small intestinal submucosa (SIS). Biomaterials, 2011, 32(3): 706-713.
9.	Raghavan D, Kropp BP, Lin HK, et al. Physical characteristics of small intestinal submucosa scaffolds are location-dependent. J Biomed Mater Res A, 2005, 73(1): 90-96.
10.	Basile P, Dadali T, Jacobson J, et al. Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. Mol Ther, 2008, 16(3): 466-473.
11.	Giannini S, Buda R, Caprio F, et al. Effects of freezing on the biomechanical and structural properties of human posterior tibial tendons. Int Orthop, 2008, 32(2): 145-151.
12.	Ott HC, Matthiesen TS, Goh SK, et al. Perfusion-decellularized matrix: using nature, s platform to engineer a bioartificial heart. Nat Med, 2008, 14(2): 213-221.
13.	罗静聪, 李秀群, 杨志明, 等. 脱细胞羊膜的制备及其生物相容性研究. 中国修复重建外科杂志, 2004, 18(2): 108-111.
14.	Brown B, Lindberg K, Reing J, et al. The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng, 2006, 12(3): 519-526.
15.	Hodde JP, Record RD, Liang HA, et al. Vascular endothelial growth factor in porcine- derived extracellular matrix. Endothelium, 2001, 8(1): 11-24.
16.	Joo KJ, Kim BS, Han JH, et al. Porcine vesical acellular matrix graft of tunica albuginea for penile reconstruction. Asian J Androl, 2006, 8(5): 543-548.
17.	Chun SY, Lim GJ, Kwon TG, et al. Identification and characterization of bioactive factors in bladder submucosa matrix. Biomaterials, 2007, 28(29): 4251-4256.
18.	Dahms SE, Piechota HJ, Dahiya R, et al. Composition and biomechanical properties of the bladder acellular matrix graft: comparative analysis in rat, pig and human. Br J Urol, 1998, 82(3): 411-419.
19.	Freytes DO, Badylak SF, Webster TJ, et al. Biaxial strength of multilaminated extracellular matrix scaffolds. Biomaterials, 2004, 25(2): 2353-2361.
20.	Badylak S, Kokini K, Tullius B, et al. Strength over time of a resorbable bioscaffold for body wall repair in a dog model. J Surg Res, 2001, 99(2): 282-287.
21.	Gilbert TW, Stewart-Akers AM, Simmons-Byrd A, et al. Degradation and remodeling of small intestinal submucosa in canine Achilles tendon repair. J Bone Joint Surg (Am), 2007, 89(3): 621-630.
22.	Valentin JE, Stewart-Akers AM, Gilbert TW, et al. Macrophage participation in the degradation and remodeling of extracellular matrix scaffolds. Tissue Eng Part A, 2009, 15(7): 1687-1694.
23.	Deeken CR, Eliason BJ, Pichert MD, et al. Differentiation of biologic scaffold materials through physicomechanical, thermal, and enzymatic degradation techniques. Ann Surg, 2012, 255(3): 595-604.
24.	Ferguson RE Jr, Pu LL. Repair of the abdominal donor-site fascial defect with small intestinal submucosa (Surgisis) after TRAM flap breast reconstruction. Ann Plast Surg, 2007, 58(1): 95-98.
25.	Ansaloni L, Catena F, Gagliardi S, et al. Hernia repair with porcine small-intestinal submucosa. Hernia, 2007, 11(4): 321-326.
26.	Ho KL, Witte MN, Bird ET. 8-ply small intestinal submucosa tension-free sling: spectrum of postoperative inflammation. J Urol, 2004, 171(1): 268-271.
27.	Petter-Puchner AH, Fortelny RH, Mittermayr R, et al. Adverse effects of porcine small intestine submucosa implants in experimental ventral hernia repair. Surg Endosc, 2006, 20(6): 942-946.
28.	McPherson TB, Liang H, Record RD, et al. Galalpha(1, 3)Gal epitope in porcine small intestinal submucosa. Tissue Eng, 2000, 6(3): 233-239.
29.	Galili U, Clark MR, Shohet SB, et al. Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1-3Gal epitope in primates. Proc Natl Acad Sci U S A, 1987, 84(5): 1369-1373.
30.	Galili U, Shohet SB, Kobrin E, et al. Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem, 1988, 263(33): 17755-17762.
31.	Galili U, Rachmilewitz EA, Peleg A, et al. A unique natural human IgG antibody with anti-alpha-galactosyl specificity. J Exp Med, 1984, 160(5): 1519-1531.
32.	Daly KA, Stewart-Akers AM, Hara H, et al. Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model. Tissue Eng Part A, 2009, 15(12): 3877-3888.
33.	Allman AJ, McPherson TB, Badylak SF, et al. Xenogeneic extracellular matrix grafts elicit a TH2-restricted immune response. Transplantation, 2001, 71(11): 1631-1640.
34.	黄翔, 罗静聪, 廖勇, 等. 小肠黏膜下层修复尿道的实验研究. 中国修复重建外科杂志, 2006, 20(3): 206-209.
35.	Kropp BP, Ludlow JK, Spicer D, et al. Rabbit urethral regeneration using small intestinal submucosa onlay grafts. Urology, 1998, 52(1): 138-142.
36.	Badylak SF, Lantz GC, Coffey A, et al. Small intestinal submucosa as a large diameter vascular graft in the dog. J Surg Res, 1989, 47(1): 74-80.
37.	Padalino MA, Castellani C, Dedja A, et al. Extracellular matrix graft for vascular reconstructive surgery: evidence of autologous regeneration of the neoaorta in a murine model. Eur J Cardiothorac Surg, 2012. [Epub ahead of print].
38.	Ko R, Kazacos EA, Snyder S, et al. Tensile strength comparison of small intestinal submucosa body wall repair. J Surg Res, 2006, 135(1): 9-17.
39.	Knoll LD. Use of small intestinal submucosa graft for the surgical management of Peyronie’s disease. J Urol, 2007, 178(6): 2474-2478.
40.	Malcaeney HL, Bonar F, Murrell GA. Early inflammatory reaction after rotator cuff repair with a porcine small intestine submucosal implant: a report of 4 cases. Am J Sports Med, 2005, 33(6): 907-911.
41.	Callcut RA, Schurr MJ, Sloan M, et al. Clinical experience with Alloderm: a one-staged composite dermal/epidermal replacement utilizing processed cadaver dermis and thin autografts. Burns, 2006, 32(5): 583-588.
42.	Chen F, Yoo JJ, Atala A. Acellular collagen matrix as a possible “off the shelf” biomaterial for urethral repair. Urology, 1999, 54(3): 407-410.
43.	el-Kassaby A, AbouShwared T, Atala A. Randomized comparative study between buccal mucosal and acellular bladder matrix grafts in complex anterior urethral strictures. J Urol, 2008, 179(4): 1432-1436.
44.	Limpert JN, Desai AR, Kumpf AL, et al. Repair of abdominal wall defects with bovine pericardium. Am J Surg, 2009, 198(5): e60-655.
45.	鞠晓军, 潘锋, 柏树令, 等. 人脱细胞羊膜复合脂肪源性干细胞修复大鼠全层皮肤缺损的实验研究. 中国修复重建外科杂志, 2010, 24(2): 143-149.
46.	胡云飞, 杨嗣星, 王玲珑, 等. 尿道细胞外基质在兔尿道重建中的应用. 中华整形外科杂志, 2009, 25(1): 54-57.

1. Huebsh N, Moony DJ. Inspiration and application in the evolution of biomaterials. Nature, 2009, 462(7272): 426-432.
2. 罗静聪, 杨志明, 李秀群, 等. 小肠黏膜下层细胞相容性的研究. 生物医学工程学杂志, 2004, 21(5): 800-804.
3. 韩平, 宋超, 魏强, 等. 组织工程膀胱细胞外基质生物相容性的实验研究. 四川大学学报: 医学版, 2007, 38(6): 1009-1012.
4. 孔清泉, 高博, 幸嵘, 等. 以小肠黏膜下层为支架体外构建组织工程软骨的实验研究. 生物医学工程学杂志, 2011, 28(3): 521-525.
5. Zhu WD, Xu YM, Feng C, et al. Different bladder defects reconstructed with bladder acellular matrix grafts in a rabbit model. Urologe A, 2011, 50(11): 1420-1425.
6. Gilbert TW, Sellaro TL, Badylak SF. Decellularization of tissues and organs. Biomaterials, 2006, 27(19): 3675-3683.
7. 罗静聪, 杨志明. 小肠黏膜下层的制备及其特性的研究进展. 中国修复重建外科杂志, 2003, 17(5): 425-428.
8. Luo JC, Chen W, Chen XH, et al. A multi-step method for preparation of porcine small intestinal submucosa (SIS). Biomaterials, 2011, 32(3): 706-713.
9. Raghavan D, Kropp BP, Lin HK, et al. Physical characteristics of small intestinal submucosa scaffolds are location-dependent. J Biomed Mater Res A, 2005, 73(1): 90-96.
10. Basile P, Dadali T, Jacobson J, et al. Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. Mol Ther, 2008, 16(3): 466-473.
11. Giannini S, Buda R, Caprio F, et al. Effects of freezing on the biomechanical and structural properties of human posterior tibial tendons. Int Orthop, 2008, 32(2): 145-151.
12. Ott HC, Matthiesen TS, Goh SK, et al. Perfusion-decellularized matrix: using nature, s platform to engineer a bioartificial heart. Nat Med, 2008, 14(2): 213-221.
13. 罗静聪, 李秀群, 杨志明, 等. 脱细胞羊膜的制备及其生物相容性研究. 中国修复重建外科杂志, 2004, 18(2): 108-111.
14. Brown B, Lindberg K, Reing J, et al. The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng, 2006, 12(3): 519-526.
15. Hodde JP, Record RD, Liang HA, et al. Vascular endothelial growth factor in porcine- derived extracellular matrix. Endothelium, 2001, 8(1): 11-24.
16. Joo KJ, Kim BS, Han JH, et al. Porcine vesical acellular matrix graft of tunica albuginea for penile reconstruction. Asian J Androl, 2006, 8(5): 543-548.
17. Chun SY, Lim GJ, Kwon TG, et al. Identification and characterization of bioactive factors in bladder submucosa matrix. Biomaterials, 2007, 28(29): 4251-4256.
18. Dahms SE, Piechota HJ, Dahiya R, et al. Composition and biomechanical properties of the bladder acellular matrix graft: comparative analysis in rat, pig and human. Br J Urol, 1998, 82(3): 411-419.
19. Freytes DO, Badylak SF, Webster TJ, et al. Biaxial strength of multilaminated extracellular matrix scaffolds. Biomaterials, 2004, 25(2): 2353-2361.
20. Badylak S, Kokini K, Tullius B, et al. Strength over time of a resorbable bioscaffold for body wall repair in a dog model. J Surg Res, 2001, 99(2): 282-287.
21. Gilbert TW, Stewart-Akers AM, Simmons-Byrd A, et al. Degradation and remodeling of small intestinal submucosa in canine Achilles tendon repair. J Bone Joint Surg (Am), 2007, 89(3): 621-630.
22. Valentin JE, Stewart-Akers AM, Gilbert TW, et al. Macrophage participation in the degradation and remodeling of extracellular matrix scaffolds. Tissue Eng Part A, 2009, 15(7): 1687-1694.
23. Deeken CR, Eliason BJ, Pichert MD, et al. Differentiation of biologic scaffold materials through physicomechanical, thermal, and enzymatic degradation techniques. Ann Surg, 2012, 255(3): 595-604.
24. Ferguson RE Jr, Pu LL. Repair of the abdominal donor-site fascial defect with small intestinal submucosa (Surgisis) after TRAM flap breast reconstruction. Ann Plast Surg, 2007, 58(1): 95-98.
25. Ansaloni L, Catena F, Gagliardi S, et al. Hernia repair with porcine small-intestinal submucosa. Hernia, 2007, 11(4): 321-326.
26. Ho KL, Witte MN, Bird ET. 8-ply small intestinal submucosa tension-free sling: spectrum of postoperative inflammation. J Urol, 2004, 171(1): 268-271.
27. Petter-Puchner AH, Fortelny RH, Mittermayr R, et al. Adverse effects of porcine small intestine submucosa implants in experimental ventral hernia repair. Surg Endosc, 2006, 20(6): 942-946.
28. McPherson TB, Liang H, Record RD, et al. Galalpha(1, 3)Gal epitope in porcine small intestinal submucosa. Tissue Eng, 2000, 6(3): 233-239.
29. Galili U, Clark MR, Shohet SB, et al. Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1-3Gal epitope in primates. Proc Natl Acad Sci U S A, 1987, 84(5): 1369-1373.
30. Galili U, Shohet SB, Kobrin E, et al. Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells. J Biol Chem, 1988, 263(33): 17755-17762.
31. Galili U, Rachmilewitz EA, Peleg A, et al. A unique natural human IgG antibody with anti-alpha-galactosyl specificity. J Exp Med, 1984, 160(5): 1519-1531.
32. Daly KA, Stewart-Akers AM, Hara H, et al. Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model. Tissue Eng Part A, 2009, 15(12): 3877-3888.
33. Allman AJ, McPherson TB, Badylak SF, et al. Xenogeneic extracellular matrix grafts elicit a TH2-restricted immune response. Transplantation, 2001, 71(11): 1631-1640.
34. 黄翔, 罗静聪, 廖勇, 等. 小肠黏膜下层修复尿道的实验研究. 中国修复重建外科杂志, 2006, 20(3): 206-209.
35. Kropp BP, Ludlow JK, Spicer D, et al. Rabbit urethral regeneration using small intestinal submucosa onlay grafts. Urology, 1998, 52(1): 138-142.
36. Badylak SF, Lantz GC, Coffey A, et al. Small intestinal submucosa as a large diameter vascular graft in the dog. J Surg Res, 1989, 47(1): 74-80.
37. Padalino MA, Castellani C, Dedja A, et al. Extracellular matrix graft for vascular reconstructive surgery: evidence of autologous regeneration of the neoaorta in a murine model. Eur J Cardiothorac Surg, 2012. [Epub ahead of print].
38. Ko R, Kazacos EA, Snyder S, et al. Tensile strength comparison of small intestinal submucosa body wall repair. J Surg Res, 2006, 135(1): 9-17.
39. Knoll LD. Use of small intestinal submucosa graft for the surgical management of Peyronie’s disease. J Urol, 2007, 178(6): 2474-2478.
40. Malcaeney HL, Bonar F, Murrell GA. Early inflammatory reaction after rotator cuff repair with a porcine small intestine submucosal implant: a report of 4 cases. Am J Sports Med, 2005, 33(6): 907-911.
41. Callcut RA, Schurr MJ, Sloan M, et al. Clinical experience with Alloderm: a one-staged composite dermal/epidermal replacement utilizing processed cadaver dermis and thin autografts. Burns, 2006, 32(5): 583-588.
42. Chen F, Yoo JJ, Atala A. Acellular collagen matrix as a possible “off the shelf” biomaterial for urethral repair. Urology, 1999, 54(3): 407-410.
43. el-Kassaby A, AbouShwared T, Atala A. Randomized comparative study between buccal mucosal and acellular bladder matrix grafts in complex anterior urethral strictures. J Urol, 2008, 179(4): 1432-1436.
44. Limpert JN, Desai AR, Kumpf AL, et al. Repair of abdominal wall defects with bovine pericardium. Am J Surg, 2009, 198(5): e60-655.
45. 鞠晓军, 潘锋, 柏树令, 等. 人脱细胞羊膜复合脂肪源性干细胞修复大鼠全层皮肤缺损的实验研究. 中国修复重建外科杂志, 2010, 24(2): 143-149.
46. 胡云飞, 杨嗣星, 王玲珑, 等. 尿道细胞外基质在兔尿道重建中的应用. 中华整形外科杂志, 2009, 25(1): 54-57.

Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH PROGRESS OF EXTRACELLULAR MATRIX MATERIAL FOR TISSUE ENGINEERING

Abstract Full text Figures/Tables Video References Cited by

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