PROGRESS OF MALLEABLE BONE PASTE/PUTTY_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZHANG Naili ^1,2 , LI Baoxing ^1,2 , ZHANG Yumin ² , ZHOU Mo ^1,2

1Department of Anatomy, Southern Medical University, Guangzhou Guangdong, 510515, P.R.China;;
2Shanxi Medical Tissue Bank, China Institute for Radiation Protection. Corresponding author: LI Baoxing, E-mail: LBXING1955@163.com;

Corresponding author：

Keywords：

Malleable bone paste/putty; Osteogenic matrix particle; Viscosity carrier

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Objective To review the progress and clinical application of malleable bone paste/putty. MethodsRecent literature about malleable bone paste/putty was reviewed and analyzed. ResultsThe preparation and clinical application of malleable bone paste/putty have become increasingly mature. Many kinds of malleable bone paste/putty have been applied extensively and the good clinical results have been achieved in the treatment of the irregular bone defects. The materials and methods for preparing malleable bone paste/putty are different. Then they have different bone repair abilities. ConclusionMalleable bone paste/putty provides effective method to treat irregular bone defects. But the malleable bone paste/putty still has some shortage, so further researches should be carried out.

Citation： ZHANG Naili,LI Baoxing,ZHANG Yumin,ZHOU Mo. PROGRESS OF MALLEABLE BONE PASTE/PUTTY. Chinese Journal of Reparative and Reconstructive Surgery, 2012, 26(11): 1381-1397. doi: Copy

1.	Durham SR, McComb JG, Levy ML. Correction of large (>25 cm(2)) cranial defects with “reinforced” hydroxyapatite cement: technique and complications. Neurosurgery, 2003, 52(4): 842-845.
2.	Baroth S, Bourges X, Goyenvalle E, et al. Injectable biphasic calcium phosphate bioceramic: The HYDROS concept. Biomed Mater Eng, 2009, 19(1): 71-76.
3.	Babbush CA. Histologic evaluation of human biopsies after dental augmentation with a demineralized bone matrix putty. Implant Dent, 2003, 12(4): 325-332.
4.	Yee AJ, Bae HW, Friess D, et al. Augmentation of rabbit posterolateral spondylodesis using a novel demineralized bone matrix-hyaluronan putty. Spine (Phila Pa 1976), 2003, 28(21): 2435-2440.
5.	Pietrzak WS, Perns SV, Keyes J, et al. Demineralized bone matrix graft: a scientific and clinical case study assessment. J Foot Ankle Surg, 2005, 44(5): 345-353.
6.	Wildemann B, Kadow-Romacker A, Haas NP, et al. Quantification of various growth factors in different demineralized bone matrix preparations. J Biomed Mater Res A, 2007, 81(2): 437-442.
7.	Bae H, Zhao L, Zhu D, et al. Variability across ten production lots of a single demineralized bone matrix product. J Bone Joint Surg (Am), 2010, 92(2): 427-435.
8.	Wang Z, Lu B, Chen L, et al. Evaluation of an osteostimulative putty in the sheep spine. J Mater Sci Mater Med, 2011, 22(1): 185-191.
9.	Kobayashi H, Turner AS, Seim HB 3rd, et al. Evaluation of a silica-containing bone graft substitute in a vertebral defect model. J Biomed Mater Res A, 2010, 92(2): 596-603.
10.	Chan C, Thompson I, Robinson P, et al. Evaluation of Bioglass/dextran composite as a bone graft substitute. Int J Oral Maxillofac Surg, 2002, 31(1): 73-77.
11.	Butz F, Bächle M, Ofer M, et al. Sinus augmentation with bovine hydroxyapatite/synthetic peptide in a sodium hyaluronate carrier (PepGen P-15 Putty): a clinical investigation of different healing times. Int J Oral Maxillofac Implants, 2011, 26(6): 1317-1323.
12.	Artzi Z, Weinreb M, Tal H, et al. Experimental intrabony and periodontal defects treated with natural mineral combined with a synthetic cell-binding Peptide in the canine: morphometric evaluations. J Periodontol, 2006, 77(10): 1658-1664.
13.	Lee JH, Lee KM, Baek HR, et al. Combined effects of porous hydroxyapatite and demineralized bone matrix on bone induction: in vitro and in vivo study using a nude rat model. Biomed Mater, 2011, 6(1): 015008.
14.	Kato M, Namikawa T, Terai H, et al. Ectopic bone formation in mice associated with a lactic acid/dioxanone/ethylene glycol copolymer-tricalcium phosphate composite with added recombinant human bone morphogenetic protein-2. Biomaterials, 2006, 27(21): 3927-3933.
15.	Cook SD, Salkeld SL, Patron LP. Bone defect healing with an osteogenic protein-1 device combined with carboxymethylcellulose. J Biomed Mater Res B Appl Biomater, 2005, 75(1): 137-145.
16.	Turner TM, Urban RM, Hall DJ, et al. Restoration of large bone defects using a hard-setting, injectable putty containing demineralized bone particles compared to cancellous autograft bone. Orthopedics, 2003, 26(5 Suppl): s561-565.
17.	Sbordone L, Bortolaia C, Perrotti V, et al. Clinical and histologic analysis of calcium sulfate in treatment of a post-extraction defect: a case report. Implant Dent, 2005, 14(1): 82-87.
18.	Bucholz RW. Nonallograft osteoconductive bone graft substitutes. Clin Orthop Relat Res, 2002, (395): 44-52.
19.	Callan DP, Salkeld SL, Scarborough N. Histologic analysis of implant sites after grafting with demineralized bone matrix putty and sheets. Implant Dent, 2000, 9(1): 36-44.
20.	Wang JC, Kanim LE, Nagakawa IS, et al. Dose-dependent toxicity of a commercially available demineralized bone matrix material. Spine (Phila Pa 1976), 2001, 26(13): 1429-1436.
21.	Gertzman AA, Hae Sunwoo M. A pilot study evaluating sodium hyaluronate as a carrier for freeze-dried demineralized bone powder. Cell Tissue Bank, 2001, 2(2): 87-94.
22.	Vastardis S, Yukna RA, Mayer ET, et al. Periodontal regeneration with peptide-enhanced anorganic bone matrix in particulate and putty form in dogs. J Periodontol, 2005, 76(10): 1690-1696.
23.	Tian M, Yang Z, Kuwahara K, et al. Delivery of demineralized bone matrix powder using a thermogelling chitosan carrier. Acta Biomater, 2012, 8(2): 753-762.
24.	Ishikawa K, Miyamoto Y, Takechi M, et al. Non-decay type fast-setting calcium phosphate cement: hydroxyapatite putty containing an increased amount of sodium alginate. J Biomed Mater Res, 1997, 36(3): 393-399.
25.	Bennett S, Connolly K, Lee DR, et al. Initial biocompatibility studies of a novel degradable polymeric bone substitute that hardens in situ. Bone, 1996, 19(1 Suppl): 101S-107S.
26.	Domb AJ, Manor N, Elmalak O. Biodegradable bone cement compositions based on acrylate and epoxide terminated poly (propylene fumarate) oligomers and calcium salt compositions. Biomaterials, 1996, 17(4): 411-417.
27.	Smucker JD, Petersen EB, Fredericks DC. Assessment of mastergraft ? putty as a graft extender in a rabbit posterolateral fusion model. Spine (Phila Pa 1976), 2011. [Epub ahead of print].
28.	Han B, Tang B, Nimni ME. Combined effects of phosphatidylcholine and demineralized bone matrix on bone induction. Connect Tissue Res, 2003, 44(3-4): 160-166.
29.	Barbieri D, Yuan HP, Groot FD, et al. Influence of different polymeric gels on the ectopic bone forming ability of an osteoinductive biphasic calcium phosphate ceramic. Acta Biomaterialia, 2011, 7(5): 2007-2014.
30.	Clokie CM, Moghadam H, Jackson MT, et al. Closure of critical sized defects with allogenic and alloplastic bone substitutes. J Craniofac Surg, 2002, 13(1): 111-123.
31.	Peterson B, Whang PG, Iglesias R, et al. Osteoinductivity of commercially available demineralized bone matrix. Preparations in a spine fusion model. J Bone Joint Surg (Am), 2004, 86-A(10): 2243-2250.
32.	Chesmel KD, Branger J, Wertheim H, et al. Healing response to various forms of human demineralized bone matrix in athymic rat cranial defects. J Oral Maxillofac Surg, 1998, 56(7): 857-855.
33.	Lee YP, Jo M, Luna M, et al. The efficacy of different commercially available demineralized bone matrix substances in an athymic rat model. J Spinal Disord Tech, 2005, 18(5): 439-444.
34.	Jensen SS, Terheyden H. Bone augmentation procedures in localized defects in the alveolar ridge: clinical results with different bone grafts and bone-substitute materials. Int J Oral Maxillofac Implants, 2009, 24 Suppl: 218-236.
35.	Güven A, Ungör C, Cizmeci ?enel F, et al. Radiologic evaluation of putty versus powder form of demineralized bone matrix in sinus floor elevation. J Oral Implantol, 2012, 38(4): 337-343.
36.	Bender SA, Rogalski JB, Mills MP, et al. Evaluation of demineralized bone matrix paste and putty in periodontal intraosseous defects. J Periodontol, 2005, 76(5): 768-777.
37.	Kaya Y, Yalim M, Bahçecitapar M, et al. Comparison of applying particulate demineralized bone matrix (DBM), putty DBM and open flap debridement in periodontal horizontal bone defects. A 12-month longitudinal, multi-center, triple-blind, split-mouth, randomized, controlled clinical study. Part 1—clinical and radiographic evaluation. J Oral Rehabil, 2009, 36(7): 524-534.
38.	Bhongade ML, Tiwari IR. A comparative evaluation of the effectiveness of an anorganic bone matrix/cell binding peptide with an open flap debridement in human infrabony defects: a clinical and radiographic study. J Contemp Dent Pract, 2007, 8(6): 25-34.
39.	Samartzis D, Marco RA. Osteochondroma of the sacrum: a case report and review of the literature. Spine (Phila Pa 1976), 2006, 31(13): E425-429.
40.	Wilkins RM, Kelly CM. The effect of allomatrix injectable putty on the outcome of long bone applications. Orthopedics, 2003, 26(5 Suppl): s567-570.
41.	Modi CS, Wicks L, Srinivasan K. Reconstruction of humeral head defect for locked posterior shoulder dislocation. Orthopedics, 2009, 32(9): 691.
42.	Thordarson DB, Kuehn S. Use of demineralized bone matrix in ankle/hindfoot fusion. Foot Ankle Int, 2003, 24(7): 557-560.
43.	Kanayama M, Hashimoto T, Shigenobu K, et al. A prospective randomized study of posterolateral lumbar fusion using osteogenic protein-1 (OP-1) versus local autograft with ceramic bone substitute: emphasis of surgical exploration and histologic assessment. Spine (Phila Pa 1976), 2006, 31(10): 1067-1074.
44.	Lee B, Woo P. Use of injectable hydroxyapatite in the secondary setting to restore glottic competence after partial laryngectomy with arytenoidectomy. Ann Otol Rhinol Laryngol, 2004, 113(8): 618-622.
45.	Leatherman BD, Dornhoffer JL, Fan CY, et al. Demineralized bone matrix as an alternative for mastoid obliteration and posterior canal wall reconstruction: results in an animal model. Otol Neurotol, 2001, 22(6): 731-736.
46.	Maruyama J, Gyo K, Hinohira Y, et al. Staged intact canal wall tympanoplasty for treatment of middle ear cholesteatoma. Nihon Jibiinkoka Gakkai Kaiho, 1998, 101(2): 236-242.
47.	Lewis KN, Thomas MV, Puleo DA. Mechanical and degradation behavior of polymer-calcium sulfate composites. J Mater Sci Mater Med, 2006, 17(6): 531-537.
48.	Reynolds MA, Aichelmann-Reidy ME, Kassolis JD, et al. Calcium sulfate-carboxymethylcellulose bone graft binder: Histologic and morphometric evaluation in a critical size defect. J Biomed Mater Res B Appl Biomater, 2007, 83(2): 451-458.
49.	Blumenthal NM, Koh-Kunst G, Alves ME, et al. Effect of surgical implantation of recombinant human bone morphogenetic protein-2 in a bioabsorbable collagen sponge or calcium phosphate putty carrier in intrabony periodontal defects in the baboon. J Periodontol, 2002, 73(12): 1494-1506.
50.	Lu J, Bhargav D, Wei AQ, et al. Posterolateral intertransverse spinal fusion possible in osteoporotic rats with BMP-7 in a higher dose delivered on a composite carrier. Spine (Phila Pa 1976), 2008, 33(3): 242-249.
51.	Bomback DA, Grauer JN, Lugo R, et al. Comparison of posterolateral lumbar fusion rates of Grafton Putty and OP-1 Putty in an athymic rat model. Spine (Phila Pa 1976), 2004, 29(15): 1612-1617.
52.	Li W, Lee M, Whang J, et al. Delivery of lyophilized Nell-1 in a rat spinal fusion model. Tissue Eng Part A, 2010, 16(9): 2861-2870.
53.	Smiler D, Soltan M, Lee JW. A histomorphogenic analysis of bone grafts augmented with adult stem cells. Implant Dent, 2007, 16(1): 42-53.
54.	Vaccaro AR, Stubbs HA, Block JE. Demineralized bone matrix composite grafting for posterolateral spinal fusion. Orthopedics, 2007, 30(7): 567-570.
55.	Lindsey RW, Wood GW, Sadasivian KK, et al. Grafting long bone fractures with demineralized bone matrix putty enriched with bone marrow: pilot findings. Orthopedics, 2006, 29(10): 939-941.
56.	Moore ST, Katz JM, Zhukauskas RM, et al. Osteoconductivity and osteoinductivity of Puros(R) DBM putty. J Biomater Appl, 2011, 26(2): 151-171.
57.	Mhawi AA, Peel SA, Fok TC, et al. Bone regeneration in athymic calvarial defects with Accell DBM100. J Craniofac Surg, 2007, 18(3): 497-503.

1. Durham SR, McComb JG, Levy ML. Correction of large (>25 cm(2)) cranial defects with “reinforced” hydroxyapatite cement: technique and complications. Neurosurgery, 2003, 52(4): 842-845.
2. Baroth S, Bourges X, Goyenvalle E, et al. Injectable biphasic calcium phosphate bioceramic: The HYDROS concept. Biomed Mater Eng, 2009, 19(1): 71-76.
3. Babbush CA. Histologic evaluation of human biopsies after dental augmentation with a demineralized bone matrix putty. Implant Dent, 2003, 12(4): 325-332.
4. Yee AJ, Bae HW, Friess D, et al. Augmentation of rabbit posterolateral spondylodesis using a novel demineralized bone matrix-hyaluronan putty. Spine (Phila Pa 1976), 2003, 28(21): 2435-2440.
5. Pietrzak WS, Perns SV, Keyes J, et al. Demineralized bone matrix graft: a scientific and clinical case study assessment. J Foot Ankle Surg, 2005, 44(5): 345-353.
6. Wildemann B, Kadow-Romacker A, Haas NP, et al. Quantification of various growth factors in different demineralized bone matrix preparations. J Biomed Mater Res A, 2007, 81(2): 437-442.
7. Bae H, Zhao L, Zhu D, et al. Variability across ten production lots of a single demineralized bone matrix product. J Bone Joint Surg (Am), 2010, 92(2): 427-435.
8. Wang Z, Lu B, Chen L, et al. Evaluation of an osteostimulative putty in the sheep spine. J Mater Sci Mater Med, 2011, 22(1): 185-191.
9. Kobayashi H, Turner AS, Seim HB 3rd, et al. Evaluation of a silica-containing bone graft substitute in a vertebral defect model. J Biomed Mater Res A, 2010, 92(2): 596-603.
10. Chan C, Thompson I, Robinson P, et al. Evaluation of Bioglass/dextran composite as a bone graft substitute. Int J Oral Maxillofac Surg, 2002, 31(1): 73-77.
11. Butz F, Bächle M, Ofer M, et al. Sinus augmentation with bovine hydroxyapatite/synthetic peptide in a sodium hyaluronate carrier (PepGen P-15 Putty): a clinical investigation of different healing times. Int J Oral Maxillofac Implants, 2011, 26(6): 1317-1323.
12. Artzi Z, Weinreb M, Tal H, et al. Experimental intrabony and periodontal defects treated with natural mineral combined with a synthetic cell-binding Peptide in the canine: morphometric evaluations. J Periodontol, 2006, 77(10): 1658-1664.
13. Lee JH, Lee KM, Baek HR, et al. Combined effects of porous hydroxyapatite and demineralized bone matrix on bone induction: in vitro and in vivo study using a nude rat model. Biomed Mater, 2011, 6(1): 015008.
14. Kato M, Namikawa T, Terai H, et al. Ectopic bone formation in mice associated with a lactic acid/dioxanone/ethylene glycol copolymer-tricalcium phosphate composite with added recombinant human bone morphogenetic protein-2. Biomaterials, 2006, 27(21): 3927-3933.
15. Cook SD, Salkeld SL, Patron LP. Bone defect healing with an osteogenic protein-1 device combined with carboxymethylcellulose. J Biomed Mater Res B Appl Biomater, 2005, 75(1): 137-145.
16. Turner TM, Urban RM, Hall DJ, et al. Restoration of large bone defects using a hard-setting, injectable putty containing demineralized bone particles compared to cancellous autograft bone. Orthopedics, 2003, 26(5 Suppl): s561-565.
17. Sbordone L, Bortolaia C, Perrotti V, et al. Clinical and histologic analysis of calcium sulfate in treatment of a post-extraction defect: a case report. Implant Dent, 2005, 14(1): 82-87.
18. Bucholz RW. Nonallograft osteoconductive bone graft substitutes. Clin Orthop Relat Res, 2002, (395): 44-52.
19. Callan DP, Salkeld SL, Scarborough N. Histologic analysis of implant sites after grafting with demineralized bone matrix putty and sheets. Implant Dent, 2000, 9(1): 36-44.
20. Wang JC, Kanim LE, Nagakawa IS, et al. Dose-dependent toxicity of a commercially available demineralized bone matrix material. Spine (Phila Pa 1976), 2001, 26(13): 1429-1436.
21. Gertzman AA, Hae Sunwoo M. A pilot study evaluating sodium hyaluronate as a carrier for freeze-dried demineralized bone powder. Cell Tissue Bank, 2001, 2(2): 87-94.
22. Vastardis S, Yukna RA, Mayer ET, et al. Periodontal regeneration with peptide-enhanced anorganic bone matrix in particulate and putty form in dogs. J Periodontol, 2005, 76(10): 1690-1696.
23. Tian M, Yang Z, Kuwahara K, et al. Delivery of demineralized bone matrix powder using a thermogelling chitosan carrier. Acta Biomater, 2012, 8(2): 753-762.
24. Ishikawa K, Miyamoto Y, Takechi M, et al. Non-decay type fast-setting calcium phosphate cement: hydroxyapatite putty containing an increased amount of sodium alginate. J Biomed Mater Res, 1997, 36(3): 393-399.
25. Bennett S, Connolly K, Lee DR, et al. Initial biocompatibility studies of a novel degradable polymeric bone substitute that hardens in situ. Bone, 1996, 19(1 Suppl): 101S-107S.
26. Domb AJ, Manor N, Elmalak O. Biodegradable bone cement compositions based on acrylate and epoxide terminated poly (propylene fumarate) oligomers and calcium salt compositions. Biomaterials, 1996, 17(4): 411-417.
27. Smucker JD, Petersen EB, Fredericks DC. Assessment of mastergraft ? putty as a graft extender in a rabbit posterolateral fusion model. Spine (Phila Pa 1976), 2011. [Epub ahead of print].
28. Han B, Tang B, Nimni ME. Combined effects of phosphatidylcholine and demineralized bone matrix on bone induction. Connect Tissue Res, 2003, 44(3-4): 160-166.
29. Barbieri D, Yuan HP, Groot FD, et al. Influence of different polymeric gels on the ectopic bone forming ability of an osteoinductive biphasic calcium phosphate ceramic. Acta Biomaterialia, 2011, 7(5): 2007-2014.
30. Clokie CM, Moghadam H, Jackson MT, et al. Closure of critical sized defects with allogenic and alloplastic bone substitutes. J Craniofac Surg, 2002, 13(1): 111-123.
31. Peterson B, Whang PG, Iglesias R, et al. Osteoinductivity of commercially available demineralized bone matrix. Preparations in a spine fusion model. J Bone Joint Surg (Am), 2004, 86-A(10): 2243-2250.
32. Chesmel KD, Branger J, Wertheim H, et al. Healing response to various forms of human demineralized bone matrix in athymic rat cranial defects. J Oral Maxillofac Surg, 1998, 56(7): 857-855.
33. Lee YP, Jo M, Luna M, et al. The efficacy of different commercially available demineralized bone matrix substances in an athymic rat model. J Spinal Disord Tech, 2005, 18(5): 439-444.
34. Jensen SS, Terheyden H. Bone augmentation procedures in localized defects in the alveolar ridge: clinical results with different bone grafts and bone-substitute materials. Int J Oral Maxillofac Implants, 2009, 24 Suppl: 218-236.
35. Güven A, Ungör C, Cizmeci ?enel F, et al. Radiologic evaluation of putty versus powder form of demineralized bone matrix in sinus floor elevation. J Oral Implantol, 2012, 38(4): 337-343.
36. Bender SA, Rogalski JB, Mills MP, et al. Evaluation of demineralized bone matrix paste and putty in periodontal intraosseous defects. J Periodontol, 2005, 76(5): 768-777.
37. Kaya Y, Yalim M, Bahçecitapar M, et al. Comparison of applying particulate demineralized bone matrix (DBM), putty DBM and open flap debridement in periodontal horizontal bone defects. A 12-month longitudinal, multi-center, triple-blind, split-mouth, randomized, controlled clinical study. Part 1—clinical and radiographic evaluation. J Oral Rehabil, 2009, 36(7): 524-534.
38. Bhongade ML, Tiwari IR. A comparative evaluation of the effectiveness of an anorganic bone matrix/cell binding peptide with an open flap debridement in human infrabony defects: a clinical and radiographic study. J Contemp Dent Pract, 2007, 8(6): 25-34.
39. Samartzis D, Marco RA. Osteochondroma of the sacrum: a case report and review of the literature. Spine (Phila Pa 1976), 2006, 31(13): E425-429.
40. Wilkins RM, Kelly CM. The effect of allomatrix injectable putty on the outcome of long bone applications. Orthopedics, 2003, 26(5 Suppl): s567-570.
41. Modi CS, Wicks L, Srinivasan K. Reconstruction of humeral head defect for locked posterior shoulder dislocation. Orthopedics, 2009, 32(9): 691.
42. Thordarson DB, Kuehn S. Use of demineralized bone matrix in ankle/hindfoot fusion. Foot Ankle Int, 2003, 24(7): 557-560.
43. Kanayama M, Hashimoto T, Shigenobu K, et al. A prospective randomized study of posterolateral lumbar fusion using osteogenic protein-1 (OP-1) versus local autograft with ceramic bone substitute: emphasis of surgical exploration and histologic assessment. Spine (Phila Pa 1976), 2006, 31(10): 1067-1074.
44. Lee B, Woo P. Use of injectable hydroxyapatite in the secondary setting to restore glottic competence after partial laryngectomy with arytenoidectomy. Ann Otol Rhinol Laryngol, 2004, 113(8): 618-622.
45. Leatherman BD, Dornhoffer JL, Fan CY, et al. Demineralized bone matrix as an alternative for mastoid obliteration and posterior canal wall reconstruction: results in an animal model. Otol Neurotol, 2001, 22(6): 731-736.
46. Maruyama J, Gyo K, Hinohira Y, et al. Staged intact canal wall tympanoplasty for treatment of middle ear cholesteatoma. Nihon Jibiinkoka Gakkai Kaiho, 1998, 101(2): 236-242.
47. Lewis KN, Thomas MV, Puleo DA. Mechanical and degradation behavior of polymer-calcium sulfate composites. J Mater Sci Mater Med, 2006, 17(6): 531-537.
48. Reynolds MA, Aichelmann-Reidy ME, Kassolis JD, et al. Calcium sulfate-carboxymethylcellulose bone graft binder: Histologic and morphometric evaluation in a critical size defect. J Biomed Mater Res B Appl Biomater, 2007, 83(2): 451-458.
49. Blumenthal NM, Koh-Kunst G, Alves ME, et al. Effect of surgical implantation of recombinant human bone morphogenetic protein-2 in a bioabsorbable collagen sponge or calcium phosphate putty carrier in intrabony periodontal defects in the baboon. J Periodontol, 2002, 73(12): 1494-1506.
50. Lu J, Bhargav D, Wei AQ, et al. Posterolateral intertransverse spinal fusion possible in osteoporotic rats with BMP-7 in a higher dose delivered on a composite carrier. Spine (Phila Pa 1976), 2008, 33(3): 242-249.
51. Bomback DA, Grauer JN, Lugo R, et al. Comparison of posterolateral lumbar fusion rates of Grafton Putty and OP-1 Putty in an athymic rat model. Spine (Phila Pa 1976), 2004, 29(15): 1612-1617.
52. Li W, Lee M, Whang J, et al. Delivery of lyophilized Nell-1 in a rat spinal fusion model. Tissue Eng Part A, 2010, 16(9): 2861-2870.
53. Smiler D, Soltan M, Lee JW. A histomorphogenic analysis of bone grafts augmented with adult stem cells. Implant Dent, 2007, 16(1): 42-53.
54. Vaccaro AR, Stubbs HA, Block JE. Demineralized bone matrix composite grafting for posterolateral spinal fusion. Orthopedics, 2007, 30(7): 567-570.
55. Lindsey RW, Wood GW, Sadasivian KK, et al. Grafting long bone fractures with demineralized bone matrix putty enriched with bone marrow: pilot findings. Orthopedics, 2006, 29(10): 939-941.
56. Moore ST, Katz JM, Zhukauskas RM, et al. Osteoconductivity and osteoinductivity of Puros(R) DBM putty. J Biomater Appl, 2011, 26(2): 151-171.
57. Mhawi AA, Peel SA, Fok TC, et al. Bone regeneration in athymic calvarial defects with Accell DBM100. J Craniofac Surg, 2007, 18(3): 497-503.

Chinese Journal of Reparative and Reconstructive Surgery

PROGRESS OF MALLEABLE BONE PASTE/PUTTY

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