GU Wenqi , ZHANG Wei , CHAI Yimin.
  • Department of Orthopedics, the Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R.China.;
Flap Ischemia-reperfusion injury; Preconditioning; Antioxidant; Leukocyte inhibitor
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Objective To review the treatment methods and techniques of ischemia-reperfusion injury of flap. Methods Recent basic research l iterature concerning ischemia-reperfusion injury of flap was reviewed and analyzed in terms of treatment techniques. Results Ischemia-reperfusion injury is one of the leading causes of flap necrosis postoperatively. Interventions against any l ink of the ischemia-reperfusion injury progress could effectively reduce the damage
and improve the survival rate of flaps. Conclusion Including production of reactive oxygen species, neutrophil infiltration
etc are thought to be the main mechanisms of ischemia-reperfusion injury. Treatment including medicine administration and physical intervention against any specific l ink of ischemia-reperfusion injury can interfere or block the whole progress, which reduce the damage of ischemia-reperfusion injury and improve the survival rate of animal flap models eventually.

Citation： GU Wenqi,ZHANG Wei,CHAI Yimin.. TREATMENT OF ISCHEMIA-REPERFUSION INJURY OF FLAP. Chinese Journal of Reparative and Reconstructive Surgery, 2011, 25(3): 373-376. doi: Copy