ZONG Xianlei 1,2 , CAI Jinglong 2 , JIANG Duyin 1 , WANG Wei 1,2
  • 1Institute of Tissue Engineering of Shandong University, Jinan Shandong, 250033, P.R.China;;
  • 2Department of Plasticand Burn Surgery, the Second Hospital of Shandong University.;
Keratinocyte growth factor; Organ development; Wound healing; Tumorigenesis
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Objective To review the latest research progress on keratinocyte growth factor (KGF), to thoroughlyunderstand its basic characteristics and appl ication methods and to lay a sol id foundation for the research and development of new KGF medicines and improving the qual ity of skin substitutes. Methods Domestical and international l iteratures on KGF
in recent years were extensively reviewed and analyzed. Results KGF was secreted by mesenchymal cells and its receptors were distributed in epithel ium to promote the prol iferation, migration and differentiation of epithel ial cell specifically, which closely related to the organ development, wound heal ing, tumorigenesis and immune reconstruction. Conclusion KGF can be used to improve wound heal ing and the performance of skin substitutes. However, the structure of KGF needs to be changed to el iminate its side effects and purify its promoting effect on epithel ial cell growth.

Citation： ZONG Xianlei,CAI Jinglong,JIANG Duyin,WANG Wei. RESEARCH PROGRESS ON KERATINOCYTE GROWTH FACTOR. Chinese Journal of Reparative and Reconstructive Surgery, 2009, 23(2): 188-193. doi: Copy