Objective To introduce the research of cell transplantation for treating intervertebral disc degeneration. Methods The original articles in recent years about cell transplantation for treating intervertebral disc degeneration were extensively reviewed, and retrospective and comprehensive analysis was performed. Results Transplantation of intevertebral
disc-derived cells or BMSCs by pure cell transplantation or combined with collagen scaffold into intervertebral disc could
express nucleus pulposus-l ike phenotype. All the cells transplanted into intervertebral disc could increase extracellular matrix synthesis and rel ieve or even inhibit further intervertebral disc degeneration. Conclusion Cell transplantation for treating intervertebral disc degeneration may be a promising approach.
Citation： LIU Jie,WANG Jian.. ADVANCES OF CELL TRANSPLANTATION FOR TREATING INTERVERTEBRAL DISC DEGENERATION. Chinese Journal of Reparative and Reconstructive Surgery, 2008, 22(10): 1259-1263. doi: Copy