HUANG Hongyun 1,2 , TAN Ke 1 , CHEN Lin 1,2 , XUE Yanping 3 , WANG Hongmei 1,2 , ZHANG Jian 1,2 , ZHANG Feng 1,2 , LIU Yancheng 1,2 , XIHaitao 1,2
  • 1 Beijing Xishan Institute for Neuroregeneration and Functional Recovery in Shijingshan District, Beijing, 100041, P. R. China;;
  • 2 Department of Neurosurgery, Beijing Xishan Hospital &;
  • Beijing Rehabilitation Center;;
  • 3 Department ofRadiology, Beijing Chaoyang Hospital, Affiliated Capital University of Medical Sciences;
Amyotrophic lateral sclerosis; Olfactory ensheathing cells; Proton MR spectroscopy; ALS functional rating scale
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Objective To evaluate proton MR spectroscopy (1H-MRS) for detection of the motor cortex and adjacent brain in amyotrophic lateralsclerosis (ALS) patients with apparent upper motor neuron involvement after olfactory ensheathing cells(OECs) transplantation. Methods From December 2004 to February 2005, 7 patients with clinically definite ALS who could safely undergo MRS were admitted into the perspective study. The neurological status, ALS functional rating scale (ALSFRS), EMG, and 1H-MRS taken before and 2 weeks after operationswere carefully analyzed. The NAA/Cr and Cho/Cr ratios were measured in the cerebral peduncle,genu and posterior limb of the internal capsule, corona radiata and precentral gyrus. Results The ALSFRS in 2 cases mproved obviously whose ALSFRS increased from 30 to 33 and from 29 to 34 respectively. And 5 cases remained stable 2 weeks after OECs transplantation. Statistical analyses for all seven cases showed both theNAA/Cr and Cho/Cr ratios decreased, but in the two cases with ALSFRS improvement the NAA/Cr increased in the certain anatomic position which confirmed the neurological and EMG findings. Conclusion The proton MR spectroscopy is a suitablenoninvasive measure for ALS evaluation. The preliminary study suggests that twoof the seven ALS cases improved apparently shortterm after OECs transplantation. More patients are required for the clinical study and longer followup duration is needed for future research.

Citation： HUANG Hongyun,TAN Ke,CHEN Lin,XUE Yanping,WANG Hongmei,ZHANG Jian,ZHANG Feng,LIU Yancheng,XIHaitao. MR Spectroscopy Evaluation and Short-term Outcome of Olfactory Ensheathing Cells Transplantation in Amyotrophic Lateral Sclerosis Patients. Chinese Journal of Reparative and Reconstructive Surgery, 2007, 21(1): 52-57. doi: Copy