• Department of Orthopedic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an Shaanxi, 710038, P. R.China.;
microRNA; Stem cell; Regulation of gene exp ression; Advance
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Objective To review the advance in the experimental studies of microRNA(miRNA) and the relationship between miRNA and stem cells. Methods The related literature was reviewed, and the research findings of miRNA and stem cell were summarized. Results miRNA was noncoding small RNA (20-25 nt) involved in posttranscriptional change, that have been shown to regulate gene expressions. Ithas been reported that some kinds of miRNAs were likely important regulators forstem cells maintaining their state of selfrenewal，and play key roles in theirdifferentiation. Conclusion miRNA as regulation of gene expressions, can be served as a new way for stem cells research.

Citation： GAO Jie,YANG Tongtao,QIU Xiuchun,et al.. RESEARCH ADVANCE OF MICRORNA AND STEM CELL. Chinese Journal of Reparative and Reconstructive Surgery, 2007, 21(9): 1007-1010. doi: Copy