• Division of Stem Cell and Tissue Engineering Key Laboratory of Biotherapy of Human Diseases Ministry of Education, West China Hospital, Sichuan University. Chengdu Sichuan, P. R. China 610041.;
Tissue engineering bone; Marrow stromal stem cells; Bio-derived bone; Tibia defect; Goats
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Objective To investigate the ability to repair goat tibia defect with marrow stromal stem cells (MSCs) and bio-derived bone, and the feasibility of the compounds as bone substitute material. Methods MSCs were cultured with the bioderived bone in vitro, and the 20 mm tibia defect of goat was made and fixedwith plate. Eighteen goats were divided into experimental group, control group and blankgroup. The defects were not filled with anything in blank group, with tissue engineering bone in experimental group and bio-derived bone in control group. Therepair capability was assessed by physical, X-ray and bone mineral density examinations8,12,16, and 24 weeks after operation. Results In experimental group, the defects were partially repaired 8 weeks, and completely repaired12 and 16 weeks; there was significant difference in bone density between experimental group and control group (P＜0.05) 8,12 and 16 weeks, but no significant difference 24 weeks. The defects of blank group were not repaired 24weeks. Conclusion The tissue engineering bone can efficiently repair bone defect, and its repair capability is better than that of bio-derived bone alone both in quantity and quality of boneformation.

Citation： QI Chao,HUANG Fuguo,YANG Zhiming,et al.. RADIOLOGICAL STUDY ON REPAIR OF GOAT TIBIA DEFECT WITH MARROW STROMAL STEM CELLS AND BIODERIVED BONE. Chinese Journal of Reparative and Reconstructive Surgery, 2004, 18(2): 83-87. doi: Copy