• Department of Traumutology and Orthopedics;;
  • Nanfang Hospital;;
  • the First Military Medical University. Guangzhou Guangdong;;
  • P. R. China 510515;;
Bone morphogenetic protein; Skeletal muscle satellite cells; Proliferation; Collagen
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OBJECTIVE: To investigate the effects of bone morphogenetic protein (BMP) on the proliferation and collagen synthesis of skeletal muscle satellite cells. METHODS: Skeletal muscle satellite cells were harvested and cultured in vitro. The 0 ng/ml, 50 ng/ml, 100 ng/ml, 500 ng/ml, and 1000 ng/ml BMP were used to induce skeletal muscle satellite cells for 48 hours. Cell proliferation, rate of myotube formation and collagen-1 synthesis were measured. RESULTS: BMP promoted cell proliferation and reduced the rate of myotube formation. Collagen synthesis increased when skeletal muscle satellite cells were induced with more than 500 ng/ml BMP. And the higher the concentration of BMP was, the ber this effect became. CONCLUSION: BMP can enhance the proliferation of skeletal muscle satellite cells and change their differentiation from myoblasts to osteoblasts.

Citation： WEI Kuan hai,PEI Guo xian,JIN Dan,et al.. EFFECTS OF BONE MORPHOGENETIC PROTEIN ON PROLIFERATION AND COLLAGEN-1 SYNTHESIS OF SKELETAL MUSCLE SATELLITE CELLS. Chinese Journal of Reparative and Reconstructive Surgery, 2002, 16(6): 422-425. doi: Copy

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