OBJECTIVE To study the relationship between the changes of mRNA expression in wound tissues of diabetic ulcers and tissue repair. METHODS The mRNA expression of TGF-beta 1 and IL-6 in eight bioptic samples of diabetic ulcers were detected by RT-PCR and pathologic methods, and the surrounding normal skins from the same patients were measured as control group. RESULTS The mRNA expression levels of TGF-beta 1 were markedly decreased in the diabetic ulcers compared with control group, while the mRNA expression levels of IL-6 were increased at the same reaction conditions. CONCLUSION The different changes of mRNA expression level of TGF-beta 1 and IL-6 in wound tissue result in low production and decreased activity of TGF-beta 1 and IL-6, which lower the reparative ability of wound tissue.
Citation： FU Xiao bing,YANG Yin hui,SUN Tong zhu,et al.. TRANSFORMING GROWTH FACTOR β 1 AND INTERLEUKIN 6 mRNA EXPRESSION IN WOUND TISSUES OF PATIENTS WITH DIABETIC ULCERS. Chinese Journal of Reparative and Reconstructive Surgery, 1999, 13(5): 259-262. doi: Copy