The etiological factors and pathogenesis of retinopathy of prematurity (ROP) are still unclear, which restricted its effective prevention and treatment. The current animal model widely used in ROP investigation is oxygen-induced retinopathy model, which is lack of specificity, and does not mimic the real pathogenesis status of human ROP patients. Thus, we should refresh our concept, seek breakthroughs in multidisciplines, integrate more risk factors of ROP, utilize the rising technique in transgenic animal, and improve the evaluation system for improving the current models or explore new animal models of ROP. It is important for prevention and treatment of ROP.
Citation： 王雨生,储昭节. Urgent need of establishment of new animal models of retinopathy of prematurity. Chinese Journal of Ocular Fundus Diseases, 2012, 28(1): 8-10. doi: Copy