Objective To observe the changes in tear film after minimal vitreoretinal surgery in patients with hypertension. Methods One hundred and thirty-three eyes of 133 patients (47 patients with systemic hypertension as group A and 86 eyes without systemic hypertension as group B) underwent 23gauge or 25gauge vitreous microsurgery were enrolled in this study. The contralateral eyes were regarded as the control group. Uncomfortable symptoms score, breakup time (BUT), Schirmer′s Ⅰ test (SⅠT) and corneal fluorescein staining (CFS) were recorded before and after surgery in all patients. Data were analyzed with a Wilcoxon rank sum test, KruskalWallis oneway ANOVA and independent samples t test. Results Comparison between non surgery eyes of group A and group B indicated no statistical difference in CFS and BUT score at each followup (Z=-3.229, -2.780, -2.018, -2.379, -3.374, -3.213: t=-2.452, -2.963, -2.580, -3.018, -2.339, -2.374; P＞0.05). However, statistical difference of SⅠT between the two groups was found either 1 day before surgery or 10 days after surgery (t=-4.668, -5.384; P＜0.05). Comparing the CFS and BUT in group A at 1, 3 days after operation with 1 day before surgery, the differences were statistically significant (Z=-5.229, -4.780; P＜0.05; t=-5.633, -4.884; P=0.001). The statistical significance was noticed in SⅠT between l day before surgery and 1 day after surgery (t=-4.743, P=0.001). Comparison between uncomfortable symptoms scores of operated eyes in group A and group B revealed no significant difference between 1 and 3 days after surgery. Nineteen patients (14%) complained of pain and red eye. There was no statistical difference between CFS score at each follow-up（Z=-3.123, -3.730, -2.198, -3.379, -3.434, -2.393; P＞0.05）. There were significant differences between BUT scores of operated eyes in two groups at 1 and 3 days after operation （t=-5.537, -5.014;P＜0.05). There was also a significant statistical difference between SⅠT 1 and 3 days after operation between groups （t=-3.653, -4.371; P＜0.05). Conclusion The stability of tear film in hypertension patients is poorer than normal patients. The secretion of tears in hypertension patients declines and the tear film recovers slowly after the surgery.

Citation： lily ,ZongMing Song. Changes in tear film after minimal vitreoretinal surgery in patients with hypertension. Chinese Journal of Ocular Fundus Diseases, 2012, 28(2): 145-148. doi: Copy