Objective To observe the clinical and pathological features of uveal melanomas, and to analyze the relationship between tumor metastases or tumorinduced death and those features. Methods 53 patients with uveal melanoma diagnosed by pathological examination were enrolled. The clinical and pathological data of patients were recorded, including the age, sex, visual acuity, intraocular pressure, iris neovascularization, tumor shape, tumor size, secondary retinal detachment, tumor cell type, ciliary body invasion, sclera emissary canal invasion, optic disc invasion, extraocular spaces involvement and sclera infiltration. The follow-up was ranged from 7.2 to 66.7 months, with the mean of 37.1 months. Kaplan-Meier Method and Cox proportional hazards modeling were used to study the relationship between various factors and tumor prognosis by univariate and multivariate analysis, and draw survival curves. Results The univariate analysis showed that the largest tumor diameter ( chi;2=10.084), tumor cell type ( chi;2=18.974), the ciliary body invasion ( chi;2=12.968), sclera emissary canal invasion ( chi;2=17.814), extraocular spaces ( chi;2=4.050), the occurrence of iris neovascularization ( chi;2=9.318) and high intraocular pressure ( chi;2=9.318) are closely related to tumor metastases or tumor-induced death (P＜0.05). In multivariate analysis, the ciliary body invasion was closely related to the tumor metastases ( chi;2=4.334，P=0.037). The cell type ( chi;2=5.260) and the iris neovascularization ( chi;2=5.145) were related to tumorinduced death (P＜0.05). Cox regression survival curve showed that the risk of tumor metastases and death increased at 20-40 months after enucleation. Conclusions The prognosis of uveal melanoma is related to the tumor size, cell type, and the expansion area of tumor. We should pay close attentions to patients 20 months after surgery to detect the occurrence of metastases.
Citation： 朱瑞琳,魏文斌,李彬,顼晓琳. The relationship between the prognosis and the clinical and pathological features of uveal melanomas. Chinese Journal of Ocular Fundus Diseases, 2011, 27(5): 435-439. doi: Copy