Objective　To observe the changes of retinal nerve fiber layer (RNFL) thickness and its correlation with visual field mean defects（MD）in Parkinson prime;s disease (PD).Methods　Fifteen eyes of 15 PD patients in early stage and 18 eyes of 18 normal controls undertook RNFL examination by Stratus OCT3. Circular scans (diameter is 3.46 mm) were taken around the optic nerve head including eight quadrants (superior, inferior, temporal, nasal, temporalsuperior, temporalinferior, nasalsuperior and nasalinferior). The RNFL thickness in different quadrants in the two groups was analyzed. The visual field of PD patients was measured by central 302 program of Humphery750 visual field analyzer, and the MD was recorded. The correlation between RNFL thickness and MD was analyzed by linear correlation and regression analysis.Results　RNFL thicknesses of superior, inferior, temporal, nasal, temporalsuperior, temporalinferior, nasalsuperior, nasalinferior and average RNFL thickness in the control group were (132.7 plusmn;17.4), (141.5 plusmn;15.3) ,（83.2 plusmn;17.5）, (83.7 plusmn;22.3) ,（120.8 plusmn;21.2）, (117.9 plusmn;24.5) ,（109.6 plusmn;20.6）,（110.2 plusmn;27.7）, and（109.9 plusmn;8.5） mu;m respectively, while in the PD group they were (128.1 plusmn;25.3) , (128.6 plusmn;13.2) , (68.7 plusmn;13.5) , (76.5 plusmn;17.8) ,（102.6 plusmn;23.7）, (103.3 plusmn;14.1) ,（101.2 plusmn;20.9）,（96.6 plusmn;15.0）,（102.3 plusmn;11.9）  mu;m. Compared with each other, the differences of RNFL thickness of inferior, temporal, temporalsuperior, temporalinferior and average RNFL thickness were statistically significant（t=2.595，2.700，2.330，2.153，2.131；P=0.014，0.011，0.026，0.040，0.041）. There was a close negative relationship between average RNFL thickness and MD in PD patients (r=-0.933，P＜0.0001). Conclusions　RNFL thickness was significantly thinner in PD patients than that in the normal controls. There was a negative relationship between RNFL thickness and MD in PD patients.

Citation： 赵颖,戴惟葭. Changes of retinal nerve fiber layer thickness and its correlation with visual field mean defects in early Parkinson′s disease. Chinese Journal of Ocular Fundus Diseases, 2010, 26(4): 339-342. doi: Copy