The debate on the cell of origin of human retinoblastoma lasted for more than one century. In the recent issue of ldquo;cell rdquo;, David Cobrinik prime;s group shows that L/M cone precursors are the most likely answer as they have an intrinsic circuitry, including murine double minute 2 (MDM2), Nmyc, the nuclear receptors retinoid X receptor and thyroxine receptor 2, making them extremely sensitive to transformation following retinoblastoma gene inactivation.
Citation： 陈大年. The cell of origin of human retinoblastoma. Chinese Journal of Ocular Fundus Diseases, 2009, 25(6): 413-415. doi: Copy