Objective　To observe the changes of photopic negative response (PhNR) of electroretinography (ERG) in patients with retinal vein occlusion (RVO). Methods　A total of 30 patients (30 eyes) with retinal vein occlusion (RVO) diagnosed by indirect ophthalmoscopy and fundus fluorescein angiography (FFA) were selected; the unaffected fellow eyes of the patients and another 25 healthy agematched individuals (50 eyes) were cllected as the normal control. All of the patients underwent the examination of visual acuity, visual field, and flashERG (FERG); the normal control ones underwent FERG. In the 30 patients with RVO, there were 14 with central RVO (CRVO) and 16 with branch RVO (BRVO). According to the disease history and results of FFA, the patients were divided into 3 time groups:  lt;1 month, 1-3 months, and  gt;3 months; according to the types of RVO, the patients were divided into ischemic and nonischemic group. The amplitude of PhNR and other parameters were analysed. The relationship among the amplitude of PhNR and RVO types and time course were analyzed.Results　The amplitude of PhNR in the CRVO and BRVO eyes was (28.20 plusmn;5.8) and (36.96 plusmn;4.71)  mu;V, respectively; those in the unaffected fellow and control eyes was (61.25 plusmn;3.93) and (59.33 plusmn;16.92)  mu;V, respectively; the amplitude of PhNR was significantly smaller in the CRVO and BRVO eyes than those in the unaffected fellow or control eyes (F=10.69 and 9.80，P＜0.001; F=9.69 and 9.75，P＜0.001). The amplitude of PhNR in ischemic and nonischemic group in CRVO eyes was (22.77 plusmn;15.73) and (36.63 plusmn;12.91)  mu;V, respectively; the difference between the two groups was significant（t=6.54, P lt;0.01）. The amplitude of PhNR in ischemic and nonischemic group in BRVO eyes was (32.39 plusmn;13.22) and (46.73 plusmn;10.43)  mu;V, respectively; there was no significant difference between the two groups（t=2.12, P lt;0.05）. The amplitude of PhNR was (24.58 plusmn;14.60) and (27.94 plusmn;15.73)  mu;V, respectively, in CRVO and BRVO eyes with  lt; 1 month disease course; was (50.39 plusmn;13.80) and (58.69 plusmn;12.43)  mu;V in those with 1-3 months disease course; and was (25.40 plusmn;19.94) and (34.48 plusmn;16.72)  mu;V in those with ＞3 months diseases course. Significant difference was found between the 1-3 months group and ＞3 months group in CRVO eyes（F=4.30，P lt;0.01）. Conclusions　The amplitude of PhNRs was significantly smaller in RVO eyes than those in the unaffected fellow or control eyes.The amplitude of PhNR amplitude of ischemic type was smaller than that of nonischemic type. The amplitude of PhNR has descending，ascending，and descending tendency during the disease courses.

Citation： 张姗姗,杨安怀,陈长征,易莲芳. Changes of photopic negative response in retinal vein occlusion. Chinese Journal of Ocular Fundus Diseases, 2009, 25(6): 421-424. doi: Copy