LUO Xiaogang , CHEN Qinyuan
  • Department of Ophthalmology, Affiliated Eye Ear Nose Throat Hospital of Fudan University, Shanghai 200031, China;
Vitreous body/surgery; Retina／surgery; Fluorocarbons; Mü ller cells; Postoperative complicatioins
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Objective To investigate the effect of long-term intraocular retention of domestic perfluorocarbon liquid (PFCL) on morphology and histology of ocular tissues. Methods A total of 18 New-Zealand rabbits were randomly divided into 3 experimental groups, whose left eyes underwent intraocular injection with 0.3, 0.6, and 1.0 ml PFCL, respectively. All of the right eyes of the rabbits were in the control group. The morphological, electrophysiological and histological changes of the ocular tissue were observed 4, 8, and 12 weeks after the injection. Results No clinically significant retinopathy but only mild morphological changes were found in group 1 and 2, while obvious morphological and histological changes were found in group 3. Mild morphological and histological changes were found in all of the rabbits 4-8 weeks after the injection while significant ones were found 8-12 weeks after the injection. The results of electroretinography indicated a statistically significant decline of amplitude of b wave in group 3. Conclusions Long-term intraocular retention of few PFCL may cause mild histological changes but not affect the clinical function. Plentiful PFCL remains in eyes may lead to toxic reaction to the ocular tissue. (Chin J Ocul Fundus Dis, 2006, 22: 128-130)

Citation： LUO Xiaogang,CHEN Qinyuan. Experimental research of intraocular retention of domestic perfluorocarbon liquid. Chinese Journal of Ocular Fundus Diseases, 2006, 22(2): 128-130. doi: Copy