SHAN Haidong , ZHAO Peiquan , JIANG Dingfeng
  • Department of Ophthalmology, EENT Hospital, Fudan University, Shanghai 200031，China;
Retinopathy of prematurity; Risk factors; Factor analysis,statistical
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ObjectiveTo analyze the risk factors of severe retinopathy of prematurity (ROP) and provide consultable evidence for the rational establishment of screening standard.MethodsThe clinical data of 168 prematureinfants (gestational age less than 37 weeks) who was diagnosed in our department from Dec 2002 to Apr 2004 was analyzed retrospectively. Gender, birth count (BC), gestational age (GA), birth weight (BW), duration of oxygen therapy and vascularization devlopment of posterior and peripheral retina examined by binocular indirect ophthalmoscope after mydriasis were recorded. The results were recorded by the international classification of ROP (ICROP), and stage 1, 2 and 3 were mild ROP while threshold disease, stage 4 and 5 were severe ROP. Logistic regression was appliedto analyze the relationship of ROP and gender, BC, GA, BW, and oxygen therapy. ResultsSevere ROP was found in 91 eyes (27.1%) of 47 infants (28.0%) in 336 eyes of 168 premature infants, including threshold disease in 20 eyes (6.0%) and disease at stage 4 in 11 eyes (3.3%) in which the diseases at stage 4A was foundin 2 eyes (0.6%) and stage 4B in 9 eyes (2.7%). There were 60 eyes (17.8%) at stage 5. In all of the factors, GA, BW and oxygen therapy were found to have a significant impact on severe ROP (P=0.000, 0.000 and 0.015,α=0.05) while gender and BC were not (P=0.640 and 0.084, α=0.05). Statistic analysis of subgroupshowed that the risk of severe ROP in premature infants would increase significantly when GA≤30 weeks, BW≤1500 g or oxygen therapy  gt;4 days. Conclusions Severe ROP relates to GA, BW and oxygen therapy instead of gender and BC. The risk of occurrence of severe ROP in premature infants increases significantly when GA≤30 weeks, BW≤1500g or oxygen therapy  gt;4 days, so it is recommended to screen such premature infants carefully. (Chin J Ocul Fundus Dis,2005,21:271-274)

Citation： SHAN Haidong ,ZHAO Peiquan,JIANG Dingfeng. Analysis of risk factors of severe retinopathy of prematurity. Chinese Journal of Ocular Fundus Diseases, 2005, 21(5): 271-274. doi: Copy