GUO Linjie , WU Zhongyao , ZHENG Huling , et al
  • Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences,Guangzhou 510060, China;
Uveal neoplasms/physiopathology; Melanoma/ physiopathology; Cell cycle; Immunohistochemistry
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Objective To evaluate the role of the cell cycle related genes cyclinD1 and Bcl-2 protein expression in the pathogenesis and infilt ration of the uveal melanoma． Methods Using immunohis tochemistry to detect the cyclinD1 and bcl-2 protein expression in 96 cases of uveal melanoma． Results The expression content of bcl-2 was high in uveal melanoma, and there wasn't any relationship between bcl-2 cell positivity and tumor cell type and extrascleral extension． In contrast, cyclinD1 expression was higher in epithelial cell uveal melanoma than mix cell and spindle cell varieties． There was a positive correlation between cyclinD1 cell positivity and extrascleral extension． Conclusion The expression of bcl-2 protein is important for the survival of the uveal melanoma． CyclinD1 may serve as a sensitive index of its malignancy． (Chin J Ocul Fundus Dis, 2001,17:44-46)

Citation： GUO Linjie,WU Zhongyao,ZHENG Huling,et al. The expression and significance of the cell cycle related genes in uveal melanoma. Chinese Journal of Ocular Fundus Diseases, 2001, 17(1): 44-46. doi: Copy