• Department of Endocrinology, 1st Hospital Affliated to First Military Medical College, Guangzhou 510515,China;
Tetrahydrofolate dehydrogenase/metabolism; Diabetic retinopathy/metabolism; Polymorphism,restriction fragment length; Polymerase chain reaction
Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables References Cited by

Objectives To study the relationships between methylenetetrahydrofolate reductase(MTHFR ) gene polymorphism and diabetic retinopathy (DR) in Chinese Han race． Methods With polymerase chain reaction and restriction fragment length polymorphism (PCR-FLP), MTHFR gene 677 T mutation (cytosine is replaced by thymine in No. 677 site) was detected in 85 health controls, 62 with DR and 117 without DR of type 2　diabetics comfrimed by ophthalmoscope． Results The frequency of MTHFR variant genotypes and alleles of DR in Chinese Han race．patients were signigicantly higher than those without retinopathy and healthy controls (P lt;0．01)． Conclusions The results suggested that MTHFRgene C677T mutation was probably one of the genetic risk factors of diabetic retinopathy in Chinese Han rase． (Chin J Ocul Fundus Dis, 2001,17:198-200

Citation： WANG Longqing,WANG Jiyi,XUE Yaoming,et al. Relationship between methylenetetrahydrofolate reductase gene polymorphism and diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2001, 17(3): 198-200. doi: Copy